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Precision Medicine: The Role of the MSIDS Model in Defining, Diagnosing, and Treating Chronic Lyme Disease/Post Treatment Lyme Disease Syndrome and Other Chronic Illness: Part 2

1
HHS Tickborne Disease Working Group, Washington, DC 20201, USA
2
Hudson Valley Healing Arts Center, New York, NY 12538, USA
*
Author to whom correspondence should be addressed.
Healthcare 2018, 6(4), 129; https://doi.org/10.3390/healthcare6040129
Received: 6 August 2018 / Revised: 31 October 2018 / Accepted: 31 October 2018 / Published: 5 November 2018
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PDF [1479 KB, uploaded 19 November 2018]
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Abstract

We present a precision medical perspective to assist in the definition, diagnosis, and management of Post Treatment Lyme Disease Syndrome (PTLDS)/chronic Lyme disease. PTLDS represents a small subset of patients treated for an erythema migrans (EM) rash with persistent or recurrent symptoms and functional decline. The larger population with chronic Lyme disease is less understood and well defined. Multiple Systemic Infectious Disease Syndrome (MSIDS) is a multifactorial model for treating chronic disease(s), which identifies up to 16 overlapping sources of inflammation and their downstream effects. A patient symptom survey and a retrospective chart review of 200 patients was therefore performed on those patients with chronic Lyme disease/PTLDS to identify those variables on the MSIDS model with the greatest potential effect on regaining health. Results indicate that dapsone combination therapy decreased the severity of eight major Lyme symptoms, and multiple sources of inflammation (other infections, immune dysfunction, autoimmunity, food allergies/sensitivities, leaky gut, mineral deficiencies, environmental toxins with detoxification problems, and sleep disorders) along with downstream effects of inflammation may all affect chronic symptomatology. In part two of our observational study and review paper, we postulate that the use of this model can represent an important and needed paradigm shift in the diagnosis and treatment of chronic disease. View Full-Text
Keywords: Chronic Lyme disease; Post Treatment Lyme Disease Syndrome (PTLDS); dapsone; Multiple Systemic Infectious Disease Syndrome (MSIDS); persister bacteria; precision medicine; Chronic Variable Immune Deficiency (CVID); Postural Orthostatic Tachycardia Syndrome (POTS) Chronic Lyme disease; Post Treatment Lyme Disease Syndrome (PTLDS); dapsone; Multiple Systemic Infectious Disease Syndrome (MSIDS); persister bacteria; precision medicine; Chronic Variable Immune Deficiency (CVID); Postural Orthostatic Tachycardia Syndrome (POTS)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Horowitz, R.I.; Freeman, P.R. Precision Medicine: The Role of the MSIDS Model in Defining, Diagnosing, and Treating Chronic Lyme Disease/Post Treatment Lyme Disease Syndrome and Other Chronic Illness: Part 2. Healthcare 2018, 6, 129.

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