Relationship of Reduced Pain Intensity and Improved Quality-of-Life with Menstrual Migraine with Aspirin, Acetaminophen, and Caffeine Combination †
Abstract
:1. Introduction
2. Methods
2.1. Study Population
2.2. Outcomes [23]
2.3. Randomization
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
5-HTR | 5-hydroxytryptamine receptor |
AAC | Acetaminophen, aspirin, and caffeine |
CGRP | Calcitonin gene-related peptide |
ERs | Estrogen receptors |
GABA | Gamma-aminobutyric acid |
HRQoL | Health-related quality-of-life |
MM | Menstrual migraine |
OTC | Over-the-counter |
QoL | Quality-of-life |
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Baseline | 1 h | Absolute Change at 1 h | Relative Change at 1 h (%) | Relative Change (AAC-Placebo) at 1 h (%) | 3 h | Absolute Change at 3 h | Relative Change at 3 h (%) | Relative Change (AAC-Placebo) at 3 h (%) | 6 h | Absolute Change at 6 h | Relative Change at 6 h (%) | Relative Change (AAC-Placebo) at 6 h (%) | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pain intensity | |||||||||||||
AAC | 2.4 | 1.6 | 0.8 | 33.3% | 24.6% | 1.1 | 1.3 | 54.2% | 41.2% | 1.1 | 1.3 | 54.2% | 36.8% |
Placebo | 2.3 | 2.1 | 0.2 | 8.7% | 2.0 | 0.3 | 13.0% | 1.9 | 0.4 | 17.4% | |||
Quality-of-life | |||||||||||||
AAC | 2.1 | 1.5 | 0.6 | 28.6% | 23.8% | 1.1 | 1.0 | 47.6% | 38.1% | 1.1 | 1.0 | 47.6% | 38.1% |
Placebo | 2.1 | 2.0 | 0.1 | 4.8% | 1.9 | 0.2 | 9.5% | 1.9 | 0.2 | 9.5% |
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Mitra, A.; Araga, M.; Aher, A.; Xu, J.; Shanga, G.; Franks, B.; Petruschke, R. Relationship of Reduced Pain Intensity and Improved Quality-of-Life with Menstrual Migraine with Aspirin, Acetaminophen, and Caffeine Combination. Healthcare 2025, 13, 1032. https://doi.org/10.3390/healthcare13091032
Mitra A, Araga M, Aher A, Xu J, Shanga G, Franks B, Petruschke R. Relationship of Reduced Pain Intensity and Improved Quality-of-Life with Menstrual Migraine with Aspirin, Acetaminophen, and Caffeine Combination. Healthcare. 2025; 13(9):1032. https://doi.org/10.3390/healthcare13091032
Chicago/Turabian StyleMitra, Ashoke, Mako Araga, Abhay Aher, Jay Xu, Gilbert Shanga, Billy Franks, and Richard Petruschke. 2025. "Relationship of Reduced Pain Intensity and Improved Quality-of-Life with Menstrual Migraine with Aspirin, Acetaminophen, and Caffeine Combination" Healthcare 13, no. 9: 1032. https://doi.org/10.3390/healthcare13091032
APA StyleMitra, A., Araga, M., Aher, A., Xu, J., Shanga, G., Franks, B., & Petruschke, R. (2025). Relationship of Reduced Pain Intensity and Improved Quality-of-Life with Menstrual Migraine with Aspirin, Acetaminophen, and Caffeine Combination. Healthcare, 13(9), 1032. https://doi.org/10.3390/healthcare13091032