Recurrent Giant Ovarian Cysts in Biological Sisters: 2 Case Reports and Literature Review—Giant Ovarian Cysts in 2 Sisters
Abstract
:1. Introduction
2. Cases Presentation
2.1. Case 1
2.1.1. Clinical Presentation
2.1.2. Diagnostic Workup
2.1.3. Treatment and Outcomes
2.2. Case 2
2.2.1. Clinical Presentation
2.2.2. Diagnostic Workup
2.2.3. Treatment and Outcomes
2.2.4. Follow-Up
3. Discussion
3.1. Case Analysis
3.2. Analysis of the Causes of Recurrent Ovarian Cysts
3.2.1. Cystic Granulosa Cell Tumors
3.2.2. Aromatase Deficiency (AD) and Ovarian Luteinized Cysts
3.2.3. Hyperprolactinemia and Polycystic Ovarian Changes
3.2.4. Pituitary Gonadotropinoma and Ovarian Hyperstimulation Syndrome
3.2.5. Polycystic Ovary Syndrome (PCOS)
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Case 1 (Younger Sister) | Case 2 (Elder Sister) | |
---|---|---|
Age (years) | 16 | 19 |
BMI | 22.86 kg/m2 | 22.49 kg/m2 |
Hyperandrogenism signs | Distended abdomen, dense pubic hair and a thickened clitoris | Facial acne, dense body hair, Adam’s apple-like prominence, distended, abdomen, dense pubic hair and enlarged clitoris |
Imaging findings | Large ovarian cystic mass with a maximum diameter of about 35 cm | Large ovarian cystic mass with a maximum diameter of 43 cm |
Ovarian tumor markers | Normal | Normal |
Pelvic laparotomy findings | Large cyst in the right ovary and an 8 cm cyst in the left ovary | Large cyst in the right ovary and a smaller 11 cm cyst in the left ovary |
Pathological diagnoses | Right ovarian serous cystadenoma and a left ovarian follicular cyst | Right ovarian follicular cyst and a left ovarian mature teratoma |
Hormonal anomalies | Increased AMH, testosterone, and prolactin Decreased LH and FSH | Increased AMH and testosterone Decreased LH and FSH |
Recurrence of the ovarian cysts after surgery | Yes | Yes |
Sustained response to contraceptives | Yes | Yes |
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Liu, S.; Zeng, Q.; Hu, L.; Zeng, B.; Wu, Y.; Wang, C.; Zhou, M.; Gan, X. Recurrent Giant Ovarian Cysts in Biological Sisters: 2 Case Reports and Literature Review—Giant Ovarian Cysts in 2 Sisters. Healthcare 2025, 13, 656. https://doi.org/10.3390/healthcare13060656
Liu S, Zeng Q, Hu L, Zeng B, Wu Y, Wang C, Zhou M, Gan X. Recurrent Giant Ovarian Cysts in Biological Sisters: 2 Case Reports and Literature Review—Giant Ovarian Cysts in 2 Sisters. Healthcare. 2025; 13(6):656. https://doi.org/10.3390/healthcare13060656
Chicago/Turabian StyleLiu, Shuaibin, Qianru Zeng, Lina Hu, Biao Zeng, Yi Wu, Chenxi Wang, Min Zhou, and Xiaoling Gan. 2025. "Recurrent Giant Ovarian Cysts in Biological Sisters: 2 Case Reports and Literature Review—Giant Ovarian Cysts in 2 Sisters" Healthcare 13, no. 6: 656. https://doi.org/10.3390/healthcare13060656
APA StyleLiu, S., Zeng, Q., Hu, L., Zeng, B., Wu, Y., Wang, C., Zhou, M., & Gan, X. (2025). Recurrent Giant Ovarian Cysts in Biological Sisters: 2 Case Reports and Literature Review—Giant Ovarian Cysts in 2 Sisters. Healthcare, 13(6), 656. https://doi.org/10.3390/healthcare13060656