Small Intestine Tumors: Diagnostic Role of Multiparametric Ultrasound

Möller, Kathleen; Jenssen, Christian; Dirks, Klaus; Hollerweger, Alois; Gottschall, Heike; Faiss, Siegbert; Dietrich, Christoph F.

doi:10.3390/healthcare13212776

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Small Intestine Tumors: Diagnostic Role of Multiparametric Ultrasound

by

Kathleen Möller

¹

,

Christian Jenssen

^2,3

,

Klaus Dirks

⁴

,

Alois Hollerweger

⁵,

Heike Gottschall

¹,

Siegbert Faiss

¹ and

Christoph F. Dietrich

^6,*

¹

Medical Department I/Gastroenterology, Sana Hospital Lichtenberg, 10365 Berlin, Germany

²

Department of Internal Medicine, Krankenhaus Märkisch-Oderland, 15344 Strausberg, Germany

³

Brandenburg Institute for Clinical Ultrasound, Medical University Brandenburg, 16816 Neuruppin, Germany

⁴

Medical Clinic II, University Hospital Würzburg, 97070 Würzburg, Germany

⁵

Department of Radiology, Hospital Barmherzige Brüder, 5020 Salzburg, Austria

⁶

Ultrasound Center of Education and Excellence, 3626 Hünibach, Switzerland

^*

Author to whom correspondence should be addressed.

Healthcare 2025, 13(21), 2776; https://doi.org/10.3390/healthcare13212776 (registering DOI)

Submission received: 1 September 2025 / Revised: 24 October 2025 / Accepted: 27 October 2025 / Published: 31 October 2025

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Abstract

Small intestine tumors are rare. The four main groups include adenocarcinomas, neuroendocrine neoplasms (NEN), lymphomas, and mesenchymal tumors. The jejunum and ileum can only be examined endoscopically with device-assisted enteroscopy techniques (DAET), which are indicated only when specific clinical or imaging findings are present. The initial diagnosis of tumors of the small intestine is mostly made using computed tomography (CT). Video capsule endoscopy (VCE), computed tomography (CT) enterography, and magnetic resonance (MR) enterography are also time-consuming and costly modalities. Modern transabdominal gastrointestinal ultrasound (US) with high-resolution transducers is a dynamic examination method that is underrepresented in the diagnosis of small intestine tumors. US can visualize wall thickening, loss of wall stratification, luminal stenosis, and dilatation of proximal small-intestinal segments, as well as associated lymphadenopathy. This review aims to highlight the role and imaging features of ultrasound in the diagnosis of small-intestinal tumors.

Keywords: small intestine tumors; ultrasound; adenocarcinoma; neuroendocrine neoplasms; lymphoma; GIST

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MDPI and ACS Style

Möller, K.; Jenssen, C.; Dirks, K.; Hollerweger, A.; Gottschall, H.; Faiss, S.; Dietrich, C.F. Small Intestine Tumors: Diagnostic Role of Multiparametric Ultrasound. Healthcare 2025, 13, 2776. https://doi.org/10.3390/healthcare13212776

AMA Style

Möller K, Jenssen C, Dirks K, Hollerweger A, Gottschall H, Faiss S, Dietrich CF. Small Intestine Tumors: Diagnostic Role of Multiparametric Ultrasound. Healthcare. 2025; 13(21):2776. https://doi.org/10.3390/healthcare13212776

Chicago/Turabian Style

Möller, Kathleen, Christian Jenssen, Klaus Dirks, Alois Hollerweger, Heike Gottschall, Siegbert Faiss, and Christoph F. Dietrich. 2025. "Small Intestine Tumors: Diagnostic Role of Multiparametric Ultrasound" Healthcare 13, no. 21: 2776. https://doi.org/10.3390/healthcare13212776

APA Style

Möller, K., Jenssen, C., Dirks, K., Hollerweger, A., Gottschall, H., Faiss, S., & Dietrich, C. F. (2025). Small Intestine Tumors: Diagnostic Role of Multiparametric Ultrasound. Healthcare, 13(21), 2776. https://doi.org/10.3390/healthcare13212776

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Small Intestine Tumors: Diagnostic Role of Multiparametric Ultrasound

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