Activity Engagement Across Stages of Cognitive Health
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Participants and Procedures
- Age 60 and above.
- Subjects with
- ○
- With normal cognitive functions
- ○
- Mild cognitive impairment
- ○
- Alzheimer’s Disease related dementia.
- Participants who can provide informed consent with English reading and speaking abilities
- History of Brain and Gut related surgeries in the last five years
- History of taking antibiotics in the last 30-days, diarrhea, vomiting, inflammatory bowel disease, food poisoning,
- History of Cancer, except for non-Melanoma skin cancer
- History of neurological disorders like epilepsy, Parkinson’s disease and ALS
- Weight loss more than 10 pounds in 2 weeks.
- Cannot communicate in English.
2.3. Study Instruments
2.4. Statistical Analysis
3. Results
3.1. Demographic Characteristics
3.2. Health Behavior
3.3. Activity Engagement
3.4. Clinical Characteristics
4. Discussion
4.1. Demographic Characteristics
4.2. Health Behaviors
4.3. Activity Engagement
4.4. Clinical Characteristics
4.5. Limitations
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Appendix A
| Florida Data Population 60 Years and Over | Pre-Weighted Data | Weighted Data | ||||
|---|---|---|---|---|---|---|
| Number | % | Number | % | Number | % | |
| Total | 6,515,453 | 100.0 | 417 | 100.0 | 417 | 100.0 |
| Age | ||||||
| 60 to 64 years | 1,597,671 | 24.5 | 55 | 13.2 | 102 | 24.5 |
| 65 to 69 years | 1,428,538 | 21.9 | 100 | 24.0 | 91 | 21.9 |
| 70 to 74 years | 1,252,984 | 19.2 | 31 | 7.4 | 80 | 19.2 |
| 75 to 79 years | 1,031,541 | 15.8 | 164 | 39.3 | 66 | 15.8 |
| 80 to 84 years | 657,889 | 10.1 | 28 | 6.7 | 42 | 10.1 |
| ≥85 years | 546,830 | 8.4 | 38 | 9.4 | 35 | 8.4 |
| Gender, n (%) | ||||||
| Male | 2,997,108 | 46.0 | 151 | 36.2 | 192 | 46.0 |
| Female | 3,518,345 | 54.0 | 266 | 63.8 | 225 | 54.0 |
| Ethnicity, n (%) | ||||||
| Not Hispanic or Latino | 5,368,733 | 82.4 | 379 | 90.9 | 344 | 82.4 |
| Hispanic or Latino | 1,146,720 | 17.6 | 38 | 9.1 | 73 | 17.6 |
| Race, n (%) | ||||||
| White | 4,606,425 | 70.7 | 380 | 91.1 | 295 | 70.7 |
| African American | 651,545 | 10.0 | 18 | 4.3 | 42 | 10.0 |
| Asian | 156,371 | 2.4 | 15 | 3.6 | 10 | 2.4 |
| Others | 1,101,112 | 16.9 | 4 | 1.0 | 70 | 16.9 |
| Education, n (%) | ||||||
| Less than high school | 690,638 | 10.6 | 3 | 0.7 | 44 | 10.6 |
| High school | 1,856,904 | 28.5 | 57 | 13.7 | 119 | 28.5 |
| College | 1,869,935 | 28.7 | 16 | 3.8 | 120 | 28.7 |
| Undergraduate and higher | 2,097,976 | 32.2 | 341 | 81.8 | 134 | 32.2 |
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| All | MoCA Score | |||||
|---|---|---|---|---|---|---|
| 26–30 Points | 18–25 Points | ≤17 Points | ||||
| (n = 417) | (n = 211) | (n = 162) | (n = 44) | p-Value | Post Hoc | |
| Age (mean, SD) | 71.98 ± 8.67 | 70.61 ± 6.53 | 70.39 ± 8.48 | 84.30 ± 8.60 | <0.001 b | [≤17 points] > [26–30 points], [≤17 points] > [18–25 points] |
| 60 to 64 years | 102 (24.5) | 46 (21.8) | 56 (34.6) | 0 (0) | <0.001 b | [26–30 points] > [≤17 points], [18–25 points] > [≤17 points] |
| 65 to 69 years | 91 (21.8) | 54 (25.6) | 36 (22.2) | 1 (2.3) | [26–30 points] > [≤17 points], [18–25 points] > [≤17 points] | |
| 70 to 74 years | 80 (19.2) | 61 (28.9) | 12 (7.4) | 7 (15.9) | [26–30 points] > [18–25 points], [26–30 points] > [≤17 points], [18–25 points] > [≤17 points] | |
| 75 to 79 years | 67 (16.1) | 28 (13.3) | 35 (21.6) | 4 (9.1) | - | |
| 80 to 84 years | 42 (10.1) | 18 (8.5) | 17 (10.5) | 7 (15.9) | - | |
| ≥85 years | 35 (8.4) | 4 (1.9) | 6 (3.7) | 25 (56.8) | [≤17 points] > [26–30 points], [≤17 points] > [18–25 points] | |
| Gender, n (%) | <0.001 b | |||||
| Male | 192 (46.0) | 88 (41.7) | 98 (60.5) | 6 (13.6) | [26–30 points] > [≤17 points], [18–25 points] > [≤17 points], [18–25 points] > [26–30 points] | |
| Female | 225 (54.0) | 123 (58.3) | 64 (39.5) | 38 (86.4) | [26–30 points] > [18–25 points], [≤17 points] > [18–25 points], [≤17 points] > [26–30 points] | |
| Ethnicity, n (%) | <0.001 b | |||||
| Not Hispanic or Latino | 344 (82.5) | 184 (87.6) | 143 (88.3) | 17 (37.8) | [26–30 points] > [≤17 points], [18–25 points] > [≤17 points] | |
| Hispanic or Latino | 73 (17.5) | 26 (12.4) | 19 (11.7) | 28 (62.2) | [26–30 points] > [≤17 points], [18–25 points] > [≤17 points] | |
| Race, n (%) | <0.001 b | |||||
| White | 294 (70.7) | 131 (62.4) | 130 (80.2) | 33 (75.0) | [18–25 points] > [26–30 points], [18–25 points] > [≤17 points] | |
| African American | 41 (9.9) | 11 (5.2) | 26 (16.0) | 4 (9.1) | [18–25 points] > [26–30 points], [18–25 points] > [≤17 points] | |
| Asian | 10 (2.4) | 3 (1.4) | 6 (3.7) | 1 (2.3) | - | |
| Others | 71 (17.1) | 65 (31.0) | 0 (0) | 6 (13.6) | [26–30 points] > [18–25 points], [≤17 points] > [18–25 points] | |
| Education, n (%) | <0.001 b | |||||
| Less than high school | 44 (10.6) | 12 (5.7) | 11 (6.8) | 21 (47.7) | [≤17 points] > [18–25 points], [≤17 points] > [26–30 points] | |
| High school | 119 (28.5) | 45 (21.3) | 62 (38.3) | 12 (27.3) | [18–25 points] > [26–30 points] | |
| College | 120 (28.8) | 66 (31.3) | 50 (30.9) | 4 (9.1) | [26–30 points] > [≤17 points], [18–25 points] > [≤17 points] | |
| Undergraduate and higher | 134 (32.1) | 88 (41.7) | 39 (24.1) | 7 (15.9) | [26–30 points] > [18–25 points], [26–30 points] > [≤17 points] | |
| Economic status, n (%) | 0.026 a | |||||
| High | 65 (15.6) | 29 (13.7) | 29 (17.9) | 7 (15.9) | - | |
| Medium | 316 (75.8) | 169 (80.1) | 111 (68.5) | 36 (81.8) | [26–30 points] > [18–25 points], [≤17 points] > [18–25 points] | |
| Low | 36 (8.6) | 13 (6.2) | 22 (13.6) | 1 (2.3) | [18–25 points] > [≤17 points], [18–25 points] > [26–30 points] | |
| All | 26–30 Points | 18–25 Points | ≤17 Points | |||
|---|---|---|---|---|---|---|
| (n = 417) | (n = 211) | (n = 162) | (n = 44) | p-Value | Post Hoc | |
| Smoking status, n (%) c | <0.001 b | |||||
| Used in past 30 days | 21 (5.1) | 8 (3.8) | 14 (8.6) | 0 (0) | - | |
| Not used in past 30 days | 21 (5.1) | 2 (0.9) | 18 (11.1) | 0 (0) | [26–30 points] > [≤17 points] | |
| [18–25 points] > [≤17 points] | ||||||
| [18–25 points] > [26–30 points] | ||||||
| Former | 117 (27.9) | 55 (26.1) | 58 (35.8) | 4 (8.9) | [26–30 points] > [≤17 points] | |
| [18–25 points] > [≤17 points] | ||||||
| Never | 258 (61.9) | 146 (69.2) | 72 (44.4) | 40 (91.1) | [26–30 points] > [18–25 points] | |
| [≤17 points] > [18–25 points] | ||||||
| [≤17 points] > [26–30 points] | ||||||
| Drinking status, n (%) | <0.001 b | |||||
| Current drinker | 158 (37.9) | 100 (47.4) | 57 (35.2) | 1 (2.3) | [26–30 points] > [≤17 points] | |
| [18–25 points] > [≤17 points] | ||||||
| Former | 215 (51.6) | 102 (48.3) | 98 (60.5) | 15 (34.1) | [18–25 points] > [≤17 points] | |
| Never | 44 (10.6) | 9 (4.3) | 7 (4.3) | 28 (63.6) | [≤17 points] > [18–25 points] | |
| [≤17 points] > [26–30 points] | ||||||
| Total drinks/week (mean, SD) | 3.07±6.43 | 3.64±3.68 | 3.15±9.27 | 0.05±0.48 | 0.003 a | [26–30 points] > [≤17 points] |
| [18–25 points] > [≤17 points] | ||||||
| Heavy drinkers | 158 (37.9) | 100 (47.4) | 57 (35.2) | 1 (2.3) | [26–30 points] > [≤17 points] | |
| [18–25 points] > [≤17 points] | ||||||
| Low to moderate drinkers | 215 (51.6) | 102 (48.3) | 98 (60.5) | 15 (34.1) | <0.001 b | - |
| Never drinking | 44 (10.6) | 9 (4.3) | 7 (4.3) | 28 (63.3) | [≤17 points] > [18–25 points] | |
| [≤17 points] > [26–30 points] | ||||||
| Walking n (%) | <0.001 b | |||||
| Daily | 209 (50.0) | 89 (42.0) | 81 (50.0) | 39 (86.7) | [≤17 points] > [18–25 points] | |
| [≤17 points] > [26–30 points] | ||||||
| ≤4 times/week | 100 (24.0) | 77 (36.3) | 20 (12.3) | 3 (6.7) | [26–30 points] > [18–25 points] | |
| [26–30 points] > [≤17 points] | ||||||
| ≤2 times/week | 82 (19.7) | 36 (17.1) | 44 (27.2) | 2 (4.4) | [18–25 points] > [≤17 points] | |
| Never | 15 (3.7) | 1 (0.5) | 14 (9.3) | 0 (0) | [18–25 points] > [26–30 points] | |
| Unknown | 11 (2.6) | 9 (4.2) | 2 (1.2) | 0 (0) | - | |
| Exercise n (%) | <0.001 b | |||||
| Daily | 64 (15.4) | 23 (10.9) | 38 (23.5) | 3 (6.8) | [18–25 points] > [26–30 points] | |
| [18–25 points] > [≤17 points] | ||||||
| ≤4 times/week | 100 (24.0) | 44 (20.9) | 44 (27.2) | 12 (27.3) | – | |
| ≤2 times/week | 143 (34.3) | 105 (49.8) | 38 (23.5) | 0 (0) | [26–30 points] > [18–25 points] | |
| [26–30 points] > [≤17 points] | ||||||
| [18–25 points] > [≤17 points] | ||||||
| Never | 46 (10.9) | 19 (9.0) | 23 (14.2) | 3 (6.8) | – | |
| Unknown | 64 (15.4) | 20 (9.4) | 19 (11.7) | 26 (59.1) | [≤17 points] > [18–25 points] | |
| [≤17 points] > [26–30 points] |
| All | 26–30 Points | 18–25 Points | ≤17 Points | |||
|---|---|---|---|---|---|---|
| (n = 417) | (n = 211) | (n = 162) | (n = 44) | p-Value | Post Hoc | |
| Activities with weekly frequency, n (%) | ||||||
| Reading newspapers and magazines | <0.001 b | |||||
| Often/always (≥3 times per week) | 263 (63.1) | 151 (71.9) | 102 (63.0) | 10 (22.2) | [26–30 points] > [≤17 points] | |
| [18–25 points] > [≤17 points] | ||||||
| Never/rarely (≤2 times per week) | 152 (36.5) | 58 (27.6) | 60 (37.0) | 34 (75.6) | [26–30 points] > [≤17 points] | |
| [18–25 points] > [≤17 points] | ||||||
| Unknown | 2 (0.5) | 1 (0.5) | 0 (0) | 1 (2.2) | - | |
| Domestic chores | <0.001 b | |||||
| Often/always (≥3 times per week) | 357 (85.6) | 196 (92.9) | 151 (93.2) | 10 (22.7) | [26–30 points] > [≤17 points] | |
| [18–25 points] > [≤17 points] | ||||||
| Never/rarely (≤2 times per week) | 58 (14.0) | 14 (6.6) | 11 (6.8) | 33 (75.0) | [26–30 points] > [≤17 points] | |
| [18–25 points] > [≤17 points] | ||||||
| Unknown | 2 (0.4) | 1 (0.5) | 0 (0) | 1 (2.3) | - | |
| Driving | <0.001 b | |||||
| Often/always (≥3 times per week) | 346 (82.9) | 199 (94.3) | 143 (86.3) | 4 (9.1) | [26–30 points] > [≤17 points] | |
| [18–25 points] > [≤17 points] | ||||||
| Never/rarely (≤2 times per week) | 65 (15.7) | 11 (5.2) | 14 (8.6) | 40 (90.9) | [≤17 points] > [18–25 points] | |
| [≤17 points] > [26–30 points] | ||||||
| Unknown | 6 (1.4) | 1 (0.5) | 5 (3.1) | 0 (0) | - | |
| Leisure activity | <0.001 b | |||||
| Often/always (≥3 times per week) | 239 (57.3) | 146 (69.2) | 83 (51.2) | 10 (22.7) | [26–30 points] > [18–25 points], | |
| [26–30 points] > [≤17 points] | ||||||
| [18–25 points] > [≤17 points] | ||||||
| Never/rarely (≤2 times per week) | 176 (42.2) | 63 (29.9) | 79 (48.8) | 34 (77.3) | [≤17 points] > [18–25 points] | |
| [≤17 points] > [26–30 points] | ||||||
| [18–25 points] > [26–30 points] | ||||||
| Unknown | 2 (0.5) | 2 (0.9) | 0 (0) | 0 (0) | - | |
| Using new technology | <0.001 b | |||||
| Often/always (≥3 times per week) | 361 (86.6) | 196 (92.9) | 156 (96.3) | 9 (20.5) | [26–30 points] > [≤17 points] | |
| [18–25 points] > [≤17 points] | ||||||
| Never/rarely (≤2 times per week) | 53 (12.7) | 14 (6.6) | 5 (3.1) | 34 (77.3) | [≤17 points] > [18–25 points] | |
| [≤17 points] > [26–30 points] | ||||||
| Unknown | 3 (0.7) | 1 (0.5) | 1 (0.6) | 1 (2.3) | - | |
| Social activity | <0.001 b | |||||
| Often/always (≥3 times per week) | 178 (42.7) | 129 (61.1) | 48 (29.6) | 1 (2.3) | [26–30 points] > [18–25 points], | |
| [26–30 points] > [≤17 points] | ||||||
| [18–25 points] > [≤17 points] | ||||||
| Never/rarely (≤2 times per week) | 231 (55.4) | 79 (37.4) | 109 (67.3) | 43 (97.7) | [≤17 points] > [18–25 points] | |
| [≤17 points] > [26–30 points] | ||||||
| [18–25 points] > [26–30 points] | ||||||
| Unknown | 8 (1.9) | 3 (1.4) | 5 (3.1) | 0 (0) | - | |
| Cinema theater | <0.001 b | |||||
| Often/always (≥3 times per week) | 78 (18.6) | 22 (10.4) | 55 (34.0) | 1 (2.3) | [18–25 points] > [≤17 points] | |
| [18–25 points] > [≤17 points] | ||||||
| Never/rarely (≤2 times per week) | 321 (77.0) | 187 (88.6) | 92 (56.8) | 42 (95.4) | [26–30 points] > [18–25 points], | |
| [≤17 points] > [18–25 points] | ||||||
| Unknown | 18 (4.3) | 2 (0.9) | 15 (9.2) | 1 (2.3) | [18–25 points] > [26–30 points] | |
| Gardening | <0.001 b | |||||
| Often/always (≥3 times per week) | 150 (35.9) | 78 (37.1) | 68 (42.0) | 4 (8.9) | [26–30 points] > [≤17 points] | |
| [18–25 points] > [≤17 points] | ||||||
| Never/rarely (≤2 times per week) | 250 (60.1) | 131 (62.4) | 79 (48.8) | 40 (88.9) | [≤17 points] > [18–25 points] | |
| [≤17 points] > [26–30 points | ||||||
| [26–30 points] > [18–25 points] | ||||||
| Unknown | 17 (4.0) | 1 (0.5) | 15 (9.2) | 1 (2.2) | [18–25 points] > [26–30 points] | |
| Looking after grandchildren | 0.099 | |||||
| Often/always (≥3 times per week) | 58 (14.0) | 37 (17.5) | 20 (12.3) | 1 (2.3) | [26–30 points] > [≤17 points] | |
| Never/rarely (≤2 times per week) | 349 (83.7) | 170 (80.6) | 137 (84.6) | 42 (95.5) | [≤17 points] > [26–30 points] | |
| Unknown | 10 (2.3) | 4 (1.9) | 5 (8.1) | 1 (2.3) | - | |
| Voluntary work | <0.001 b | |||||
| Often/always (≥3 times per week) | 133 (31.9) | 90 (42.7) | 42 (25.9) | 1 (2.3) | [26–30 points] > [18–25 points] | |
| [26–30 points] > [≤17 points] | ||||||
| [18–25 points] > [≤17 points] | ||||||
| Never/rarely (≤2 times per week) | 273 (65.5) | 116 (55.0) | 115 (71.0) | 42 (95.5) | [≤17 points] > [18–25 points] | |
| [≤17 points] > [26–30 points] | ||||||
| [18–25 points] > [26–30 points] | ||||||
| Unknown | 11 (2.6) | 5 (2.4) | 5 (3.1) | 1 (2.3) | - | |
| Artistic activities | 0.003 a | |||||
| Often/always (≥3 times per week) | 98 (23.5) | 61 (28.9) | 34 (21.0) | 3 (6.8) | [26–30 points] > [≤17 points] | |
| Never/rarely (≤2 times per week) | 311 (74.7) | 149 (70.6) | 122 (75.3) | 40 (90.9) | [≤17 points] > [26–30 points] | |
| Unknown | 8 (1.9) | 1 (0.5) | 6 (3.7) | 1 (2.3) | - | |
| Activities with annual frequency, n (%) | ||||||
| Exhibitions, Concerts, Conferences | <0.001 b | |||||
| Often/always (≥3 times in a year) | 152 (36.4) | 106 (50.2) | 43 (26.5) | 3 (6.8) | [26–30 points] > [18–25 points] | |
| [26–30 points] > [≤17 points] | ||||||
| [18–25 points] > [≤17 points] | ||||||
| Never/rarely (≤2 times in a year) | 259 (62.2) | 102 (48.3) | 118 (72.8) | 39 (88.6) | [18–25 points] > [26–30 points] | |
| [≤17 points] > [26–30 points] | ||||||
| Unknown | 6 (1.4) | 3 (1.4) | 1 (0.6) | 2 (4.5) | - | |
| Journeys last several days | <0.001 b | |||||
| Often/always (≥3 times in a year) | 184 (44.2) | 135 (64.0) | 45 (27.8) | 4 (9.1) | [26–30 points] > [18–25 points] | |
| [26–30 points] > [≤17 points] | ||||||
| [18–25 points] > [≤17 points] | ||||||
| Never/rarely (≤2 times in a year) | 229 (54.8) | 73 (34.6) | 117 (72.2) | 39 (88.6) | [18–25 points] > [26–30 points] | |
| [≤17 points] > [26–30 points] | ||||||
| Unknown | 4 (1.0) | 3 (1.4) | 0 (0) | 1 (2.3) | - | |
| Reading books | 0.007 a | |||||
| Often/always (≥3 times in a year) | 197 (47.2) | 101 (47.9) | 86 (53.1) | 10 (22.7) | [26–30 points] > [≤17 points] | |
| [18–25 points] > [≤17 points] | ||||||
| Never/rarely (≤2 times in a year) | 219 (52.5) | 109 (51.6) | 76 (46.9) | 34 (77.3) | [≤17 points] > [26–30 points] | |
| [≤17 points] > [18–25 points] | ||||||
| Unknown | 1 (0.3) | 1 (0.5) | 0 (0) | 0 (0) | - | |
| Activities with fix frequency, n (%) | ||||||
| Pet care | <0.001 b | |||||
| Often/Always | 223 (53.5) | 132 (62.6) | 83 (50.2) | 8 (18.2) | [26–30 points] > [≤17 points] | |
| [18–25 points] > [≤17 points] | ||||||
| Never/rarely | 188 (45.1) | 77 (36.5) | 75 (46.3) | 36 (81.8) | [≤17 points] > [26–30 points] | |
| [≤17 points] > [18–25 points] | ||||||
| Unknown | 6 (1.4) | 2 (0.9) | 4 (2.5) | 0 (0) | - | |
| Managing current account | <0.001 b | |||||
| Often/Always | 255 (61.2) | 147 (69.7) | 101 (62.3) | 7 (15.9) | [26–30 points] > [≤17 points] | |
| [18–25 points] > [≤17 points] | ||||||
| Never/rarely | 94 (22.5) | 27 (12.8) | 35 (21.6) | 32 (72.7) | [≤17 points] > [26–30 points] | |
| [≤17 points] > [18–25 points] | ||||||
| Unknown | 68 (16.3) | 37 (17.5) | 26 (16.1) | 5 (11.4) | - | |
| All | MoCA | |||||
|---|---|---|---|---|---|---|
| (n = 417) | 26–30 Points | 18–25 Points | ≤17 Points | p-Value | Post Hoc | |
| (n = 211) | (n = 162) | (n = 44) | ||||
| Chronic diseases (mean, SD) | 3.40 ± 2.13 | 2.92 ± 1.55 | 3.70 ± 2.45 | 4.55 ± 2.62 | <0.001 b | [≤17 points] > [26–30 points], |
| [≤17 points] > [18–25 points], | ||||||
| [18–25 points] > [26–30 points] | ||||||
| Hypertension, n (%) | <0.001 b | |||||
| Yes | 139 (33.3) | 41 (19.4) | 69 (42.6) | 29 (65.9) | [≤17 points] > [26–30 points] | |
| [≤17 points] > [18–25 points], | ||||||
| [18–25 points] > [26–30 points] | ||||||
| No | 255 (61.2) | 159 (75.4) | 81 (50.0) | 15 (34.1) | [26–30points]> [18–25 points] | |
| [26–30 points] > [≤17 points] | ||||||
| Unknown | 23 (5.5) | 11 (5.2) | 12 (7.4) | 0 (0) | - | |
| Diabetes mellitus, n (%) | 0.001 b | |||||
| Yes | 46 (11.1) | 13 (6.2) | 30 (18.5) | 4 (9.1) | [18–25 points] > [26–30 points] | |
| No | 352 (84.6) | 191 (90.5) | 121 (74.7) | 40 (90.9) | [26–30 points] > [18–25 points] | |
| Unknown | 18 (4.3) | 7 (3.3) | 11 (6.8) | 0 (0) | - | |
| Non-Melanoma Cancer, n (%) | 0.025 a | |||||
| Yes | 89 (21.3) | 43 (20.4) | 40 (24.7) | 6 (13.6) | - | |
| No | 304 (72.8) | 161 (76.3) | 110 (67.9) | 33 (75.0) | - | |
| Unknown | 24 (5.9) | 7 (3.3) | 12 (7.4) | 5 (11.4) | [≤17 points] > [26–30 points] | |
| Osteoarthritis, n (%) | 0.001 b | |||||
| Yes | 137 (32.9) | 53 (25.1) | 60 (37.0) | 24 (54.5) | [18–25points]> [26–30 points] | |
| [≤17 points] > [26–30 points] | ||||||
| No | 255 (61.2) | 146 (69.2) | 89 (54.9) | 20 (45.5) | [26–30points]> [18–25 points] | |
| [26–30 points] > [≤17 points] | ||||||
| Unknown | 25 (6.0) | 12 (5.7) | 13 (8.0) | 0 (0) | - | |
| Stroke, n (%) | <0.001 b | |||||
| Yes | 27 (6.5) | 2 (0.9) | 3 (1.9) | 22 (48.9) | [≤17 points] > [26–30 points] | |
| [≤17 points] > [18–25 points] | ||||||
| No | 363 (87.1) | 195 (92.4) | 145 (90.1) | 23 (51.1) | [26–30 points] > [≤17 points] | |
| [18–25 points] > [≤17 points] | ||||||
| Unknown | 27 (6.5) | 14 (6.6) | 13 (8.1) | 0 (0) | - | |
| Osteoporosis, n (%) | 0.017 a | |||||
| Yes | 77 (18.5) | 47 (22.3) | 29 (17.9) | 1 (2.3) | [26–30 points] > [≤17 points] | |
| [18–25 points] > [≤17 points] | ||||||
| No | 318 (76.3) | 156 (73.9) | 121 (74.7) | 41 (93.2) | [≤17 points] > [26–30 points] | |
| [≤17 points] > [18–25 points] | ||||||
| Unknown | 22 (5.3) | 8 (3.8) | 12 (7.4) | 2 (4.5) | - | |
| Heart failure, n (%) | 0.343 | |||||
| Yes | 5 (1.3) | 2 (0.9) | 3 (1.9) | 0 (0) | - | |
| No | 385 (92.3) | 195 (92.4) | 146 (90.1) | 44 (100) | - | |
| Unknown | 27 (6.4) | 14 (6.6) | 13 (8.0) | 0 (0) | - | |
| HIV infection, n (%) | 0.073 | |||||
| Yes | 3 (0.7) | 0 (0) | 3 (1.9) | 0 (0) | - | |
| No | 387 (92.8) | 197 (93.4) | 146 (90.1) | 44 (100) | - | |
| Unknown | 27 (6.5) | 14 (6.6) | 13 (8.0) | 0 (0) | - | |
| Depression, n (%) | <0.001 b | |||||
| Yes | 96 (23.0) | 30 (14.2) | 39 (24.1) | 27 (61.4) | [≤17 points] > [26–30 points] | |
| [≤17 points] > [18–25 points] | ||||||
| [18–25 points] > [26–30 points] | ||||||
| No | 300 (71.9) | 171 (81.0) | 112 (69.1) | 17 (38.6) | [26–30 points] > [≤17 points] | |
| [18–25 points] > [≤17 points] | ||||||
| [26–30 points] > [18–25 points] | ||||||
| Unknown | 21 (5.0) | 10 (4.7) | 11 (6.8) | 0 (0) | - | |
| Head injury, n (%) | <0.001 b | |||||
| Yes | 85 (20.5) | 19 (9.0) | 44 (27.2) | 22 (50.0) | [≤17 points] > [26–30 points] | |
| [≤17 points] > [18–25 points] | ||||||
| [18–25 points] > [26–30 points] | ||||||
| No | 304 (72.9) | 177 (83.9) | 105 (64.8) | 22 (50.0) | [26–30points] > [18–25 points], | |
| [26–30 points] > [≤17 points] | ||||||
| Unknown | 28 (6.6) | 15 (7.1) | 13 (8.0) | 0 (0) | - | |
| Surgery, n (%) | 0.001 b | |||||
| Yes | 302 (72.4) | 167 (79.1) | 110 (67.9) | 25 (56.8) | [26–30points] > [18–25 points] | |
| [26–30 points] > [≤17 points] | ||||||
| No | 97 (23.3) | 37 (17.5) | 41 (25.3) | 19 (43.2) | [≤17 points] > [26–30 points] | |
| Unknown | 18 (4.3) | 7 (3.3) | 11 (6.8) | 0 (0) | - | |
| Substance use, n (%) | 0.022 a | |||||
| Yes | 10 (2.4) | 2 (1.0) | 8 (4.9) | 0 (0) | - | |
| No | 379 (91.0) | 194 (92.4) | 141 (87.0) | 44 (100) | [≤17 points] > [18–25 points] | |
| Unknown | 28 (6.6) | 14 (6.7) | 13 (8.0) | 0 (0) | - | |
| Infection, n (%) | 0.004 a | |||||
| Yes | 139 (33.3) | 67 (31.9) | 50 (30.7) | 22 (50.0) | - | |
| No | 251 (60.2) | 136 (64.8) | 95 (58.3) | 20 (45.5) | - | |
| Unknown | 27 (6.5) | 7 (3.3) | 18 (11.0) | 2 (4.5) | [18–25 points] > [26–30 points] | |
| Sound sleep, n (%) | 0.948 | |||||
| Yes | 123 (29.5) | 65 (30.8) | 35 (21.6) | 23 (52.3) | [≤17 points] > [26–30 points] | |
| [≤17 points] > [18–25 points] | ||||||
| No | 262 (62.8) | 131 (62.1) | 112 (69.1) | 19 (43.2) | [26–30 points] > [≤17 points] | |
| [18–25 points] > [≤17 points] | ||||||
| Unknown | 32 (7.7) | 15 (7.1) | 15 (9.3) | 2 (4.5) | - | |
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Williams, C.; Labyak, C.; Arikawa, A.; Watermann, A.; Chou, W.; James, A.; Holland, P.; Dangiolo, M.; Masternak, M.M.; Golden, A.; et al. Activity Engagement Across Stages of Cognitive Health. Healthcare 2025, 13, 2712. https://doi.org/10.3390/healthcare13212712
Williams C, Labyak C, Arikawa A, Watermann A, Chou W, James A, Holland P, Dangiolo M, Masternak MM, Golden A, et al. Activity Engagement Across Stages of Cognitive Health. Healthcare. 2025; 13(21):2712. https://doi.org/10.3390/healthcare13212712
Chicago/Turabian StyleWilliams, Cynthia, Corinne Labyak, Andrea Arikawa, Anna Watermann, Wanyun Chou, Adewale James, Peter Holland, Mariana Dangiolo, Michal M. Masternak, Adam Golden, and et al. 2025. "Activity Engagement Across Stages of Cognitive Health" Healthcare 13, no. 21: 2712. https://doi.org/10.3390/healthcare13212712
APA StyleWilliams, C., Labyak, C., Arikawa, A., Watermann, A., Chou, W., James, A., Holland, P., Dangiolo, M., Masternak, M. M., Golden, A., Jain, S., & Yadav, H. (2025). Activity Engagement Across Stages of Cognitive Health. Healthcare, 13(21), 2712. https://doi.org/10.3390/healthcare13212712

