Neurocognitive and Psychosocial Interactions in Atrial Fibrillation: Toward a Holistic Model of Care
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Cognitive Evaluation
2.3. Evaluation of Psychosocial Risk Factors
2.4. Evaluation of Quality of Life
2.5. Statistical Methods
3. Results
3.1. Psychosocial Risk Profile
3.2. Cognitive Evaluation and Psychosocial Stressors
3.3. Assessment of Quality of Life
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
AF | Atrial fibrillation |
CD | Cognitive dysfunction |
CVDs | Cardiovascular diseases |
MoCA | Montreal Cognitive Assessment |
References
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Total (n = 798) 100% | AF (n = 230) 28.8% | No AF (n = 568) 71.2% | |
---|---|---|---|
Age, yrs (mean, SD) | 68.07 (9.60) | 72.33 (8.06) | 66.35 (9.65) |
Females (n, %) | 403 (50.5) | 116 (50.4) | 287 (50.5) |
Urban (n, %) | 467 (58.5) | 131 (57.0) | 336 (59.2) |
Education level, classes (mean, SD) | 10.91 (2.88) | 10.72 (3.07) | 10.99 (2.80) |
BMI, kg/m2 (mean, SD) | 30.66 (6.02) | 30.06 (5.11) | 30.90 (6.35) |
MoCA, pts (mean, SD) | 23.03 (4.54) | 22.52 (4.68) | 23.24 (4.47) |
CD (MoCA < 26 points) (n, %) | 537 (67.3) | 169 (73.5) | 368 (64.8) |
SBP, mmHg (mean, SD) | 133.92 (18.88) | 129.97 (18.13) | 135.56 (18.96) |
DBP, mmHg (mean, SD) | 80.68 (10.71) | 78.73 (10.21) | 81.50 (10.82) |
Heart rate, bpm (mean, SD) | 73.17 (15.36) | 79.01 (20.01) | 70.70 (12.09) |
Arterial hypertension (n, %) | 747 (93.6) | 209 (90.9) | 538 (94.7) |
Type 2 diabetes (n, %) | 354 (44.4) | 98 (42.6) | 256 (45.1) |
Dyslipidemia (n, %) | 474 (59.4) | 112 (48.7) | 362 (63.7) |
HF (n, %) | 429 (53.8) | 158 (68.7) | 271 (47.7) |
IHD (n, %) | 297 (37.2) | 72 (31.3) | 225 (39.6) |
CKD (n, %) | 446 (55.9) | 146 (63.5) | 300 (52.8) |
Stroke (n, %) | 91 (11.4) | 30 (13.0) | 61 (10.7) |
Psychosocial Risk Factor | AF | No AF | p Value |
---|---|---|---|
LSS | 119 (73.9) | 311 (74.2) | <0.0001 |
WFs | 86 (60.6) | 257 (66.2) | 0.0149 |
SI | 147 (83.5) | 361 (80.8) | <0.0001 |
D | 56 (31.8) | 118 (26.4) | <0.0001 |
A | 85 (48.6) | 179 (40.6) | 0.7624 |
H | 107 (60.8) | 271 (58.3) | 0.0053 |
TDP | 89 (51.1) | 228 (51.2) | 0.8201 |
PTSD | 95 (54.0) | 231 (51.7) | 0.3271 |
Other | 9 (5.2) | 38 (8.6) | <0.0001 |
Total Sample | Female | Male | |||||||
---|---|---|---|---|---|---|---|---|---|
Psychosocial Risk Factor | Female | Male | p Value | AF | No AF | p Value | AF | No AF | p Value |
LSS | 214 (68.2) | 216 (68.4) | 0.2127 | 59 (64.1) | 155 (69.8) | 0.7887 | 60 (68.2) | 156 (68.4) | 0.2363 |
WFs | 169 (53.8) | 174 (55.1) | 0.7149 | 45 (48.9) | 124 (55.9) | 0.9781 | 41 (46.6) | 133 (58.3) | 0.4786 |
SI | 268 (85.4) | 240 (75.9) | 0.7852 | 78 (84.8) | 190 (85.6) | 0.2577 | 69 (78.4) | 171 (75.0) | 0.7261 |
D | 127 (40.4) | 47 (14.9) | 0.1466 | 41 (44.6) | 86 (38.7) | 0.6919 | 15 (17.0) | 32 (14.0) | 0.5772 |
A | 172 (54.8) | 92 (29.1) | 0.8442 | 53 (57.6) | 119 (53.6) | 0.9177 | 32 (36.4) | 60 (26.3) | 0.7492 |
H | 204 (65.0) | 174 (55.1) | 0.5379 | 57 (62.0) | 147 (66.2) | 0.8102 | 50 (56.8) | 124 (54.4) | 0.7041 |
TDP | 185 (58.9) | 132 (41.8) | 0.6020 | 52 (56.5) | 133 (59.9) | 0.8092 | 37 (42.0) | 95 (41.7) | 0.9398 |
PTSD | 199 (63.4) | 127 (40.2) | 0.9770 | 61 (66.3) | 138 (62.2) | 0.6938 | 34 (38.6) | 93 (40.8) | 0.6867 |
Other | 33 (10.5) | 14 (4.4) | 0.0005 | 7 (7.6) | 26 (11.7) | 0.7718 | 2 (2.3) | 12 (5.3) | 0.5026 |
Cognitive Domains | AF | No AF | p Value |
---|---|---|---|
Visuospacial/Executive | 3.26 (1.39) | 3.56 (1.32) | 0.0056 ** |
Naming | 2.85 (0.44) | 2.83 (0.47) | 0.4738 ** |
Attention | 4.61 (1.53) | 4.62 (1.47) | 0.9536 ** |
Language | 1.84 (0.95) | 1.95 (0.98) | 0.1048 ** |
Abstraction | 1.41 (0.77) | 1.54 (0.68) | 0.0572 ** |
Delayed recall | 2.23 (1.65) | 2.27 (1.65) | 0.7530 ** |
Orientation | 5.82 (0.47) | 5.79 (0.63) | 0.9634 ** |
AF | No AF | p Value | |
---|---|---|---|
EQ-5D-5L Score | 22,707.29 (11,749.44) | 23,144.75 (11,163.97) | 0.9089 ** |
EQ-5D-5L Scale | 65.43 (18.57) | 71.95 (18.30) | 0.0765 ** |
Paroxysmal | Persistent | Permanent | p Value | |
---|---|---|---|---|
EQ-5D-5L Score | 18,597.19 (9770.67) | 21,111.00 (-) | 28,201.56 (12,538.50) | 0.0176 * |
EQ-5D-5L Scale | 71.75 (16.16) | - (-) | 57.00 (18.69) | 0.0061 ** |
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Pal, T.; Preg, Z.; Baba, D.-F.; Balint-Szentendrey, D.; Polgar, A.; Pap, C.-G.; German-Sallo, M. Neurocognitive and Psychosocial Interactions in Atrial Fibrillation: Toward a Holistic Model of Care. Healthcare 2025, 13, 1863. https://doi.org/10.3390/healthcare13151863
Pal T, Preg Z, Baba D-F, Balint-Szentendrey D, Polgar A, Pap C-G, German-Sallo M. Neurocognitive and Psychosocial Interactions in Atrial Fibrillation: Toward a Holistic Model of Care. Healthcare. 2025; 13(15):1863. https://doi.org/10.3390/healthcare13151863
Chicago/Turabian StylePal, Tunde, Zoltan Preg, Dragos-Florin Baba, Dalma Balint-Szentendrey, Attila Polgar, Csilla-Gerda Pap, and Marta German-Sallo. 2025. "Neurocognitive and Psychosocial Interactions in Atrial Fibrillation: Toward a Holistic Model of Care" Healthcare 13, no. 15: 1863. https://doi.org/10.3390/healthcare13151863
APA StylePal, T., Preg, Z., Baba, D.-F., Balint-Szentendrey, D., Polgar, A., Pap, C.-G., & German-Sallo, M. (2025). Neurocognitive and Psychosocial Interactions in Atrial Fibrillation: Toward a Holistic Model of Care. Healthcare, 13(15), 1863. https://doi.org/10.3390/healthcare13151863