Uterine Fibroids and Pregnancy: A Review of the Challenges from a Romanian Tertiary Level Institution
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Characteristics | Overall n = 57 | CS with Myomectomy n = 12 | CS without Myomectomy n = 37 | Abortions n = 4 | Normal Births n = 4 | p-Value |
---|---|---|---|---|---|---|
Age in years, (mean ± SD) § | 34.5 ± 4.2 | 34 ± 4.3 | 34.3 ± 3.7 | 38.3 ± 4.5 | 33.5 ± 3.7 | 0.4008 |
Age, median (range) ** | 35 (31; 37) | 34 (30.5; 37.5) | 34 (31; 37) | 35 (31; 35) | 39 (34; 42) | |
Environment, U/R, n(%) † | 46/11 (80.7/19.3) | 10/2 (83.3/16.7) | 31/6 (83.8/16.2) | 3/1 (75/25) | 2/2 (50/50) | 0.4262 |
Previous abortions, n(%) | ||||||
without one abortion more than two abortions | 40 (70.3) 7 (12.2) 10 (17.5) | 7 (58.4) 1 (8.3) 4 (33.3) | 27 (72) 6 (16.2) 4 (10.8) | 4 (100) - - | 2 (50) - 2 (50) | 0.2111 |
Obese, Yes/No, n(%) | 11/46 (19.3/80.7) | 2/10 (16.7/83.3) | 6/31 (16.2/83.8) | 2/2 (50/50) | 1/3 (25/75) | 0.5198 |
Previous births | ||||||
without previous births single births multiple births | 37 (64.9) 17 (29.8) 3 (5.3) | 8 (66.7) 4 (33.3) - | 26 70.3) 9 (24.3) 2 (5.4) | 2 (50) 2 (50) - | 1 (25) 2 (50) 1 (25) | 0.4038 |
Gestational age, weeks | ||||||
mean ± SD median (range) | 38.2 ± 1.7 39 (38; 39) | 38.1 ± 1.2 38 (38; 39) | 38.3 ±1.6 39 (38; 39) | - | 37.3 ± 3.6 38 (35; 39) | 0.7464 |
Intrauterine Growth Restriction, n(%) | 6 (10.5) | 2 (16.7) | 4 (10.8) | - | - | 0.7352 |
Time of diagnosis with fibroids | ||||||
before pregnancy during pregnancy | 26 (45.6) 31 (54.4) | 4 (33.3) 8 (66.7) | 18 (48.6) 19 (51.4) | 2 (50) 2 (50) | 2 (50) 2 (50) | 0.8184 |
Number of fibroids | ||||||
single fibroids multiple fibroids | 42 (73.7) 15 (26.3) | 8 (66.7) 4 (33.3) | 27 (73) 10 (37) | 3 (75) 1 (25) | 4 (100) - | 0.4324 |
Type of fibroid | ||||||
interstitial subserous submucous | - | 28 (49.12) 26 (45.62) 3 (5.26) | - | - | - | |
Location of the myoma | ||||||
anterior uterine wall fundic region posterior wall isthmic region right lateral walls left lateral walls | - | 29 (50.87) 11 (19.3) 7 (12.28) 6 (10.52) 1(1.75) 3 (5.26) | - | - | - |
Size of Fibroid, mm | ||||
---|---|---|---|---|
Antepartum | 1st Trimester | 2nd Trimester | 3rd Trimester | |
N | 55 | 49 | 50 | 53 |
Mean | 40.02 | 44.51 p = 0.005 * | 54.76 p = 0.001 * | 61.58 p = 0.001 * |
Difference from the previous average | - | +4.49 mm (+11.2%) | +10.25 mm (+23.0%) | +6.92 mm (+12.6%) |
Median | 38 | 40 | 50 | 60 |
Std. Deviation | 18.29 | 17.21 | 21.37 | 24.54 |
Variance | 42.88 | 38.67 | 39.04 | 39.59 |
Skewness | 0.970 | 0.733 | 0.664 | 1.636 |
Std. Err. of Skewness | 0.322 | 0.340 | 0.337 | 0.327 |
Minimum | 20 | 20 | 20 | 25 |
Maximum | 90 | 90 | 100 | 160 |
25th percentile | 23 | 30 | 40 | 48 |
50th percentile | 40 | 40 | 50 | 60 |
75th percentile | 50 | 50 | 64 | 70 |
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Tîrnovanu, M.C.; Lozneanu, L.; Tîrnovanu, Ş.D.; Tîrnovanu, V.G.; Onofriescu, M.; Ungureanu, C.; Toma, B.F.; Cojocaru, E. Uterine Fibroids and Pregnancy: A Review of the Challenges from a Romanian Tertiary Level Institution. Healthcare 2022, 10, 855. https://doi.org/10.3390/healthcare10050855
Tîrnovanu MC, Lozneanu L, Tîrnovanu ŞD, Tîrnovanu VG, Onofriescu M, Ungureanu C, Toma BF, Cojocaru E. Uterine Fibroids and Pregnancy: A Review of the Challenges from a Romanian Tertiary Level Institution. Healthcare. 2022; 10(5):855. https://doi.org/10.3390/healthcare10050855
Chicago/Turabian StyleTîrnovanu, Mihaela Camelia, Ludmila Lozneanu, Ştefan Dragoş Tîrnovanu, Vlad Gabriel Tîrnovanu, Mircea Onofriescu, Carmen Ungureanu, Bogdan Florin Toma, and Elena Cojocaru. 2022. "Uterine Fibroids and Pregnancy: A Review of the Challenges from a Romanian Tertiary Level Institution" Healthcare 10, no. 5: 855. https://doi.org/10.3390/healthcare10050855