Hereditary Breast and Ovarian Cancer Service in Sparsely Populated Western Pomerania
Abstract
:1. Introduction
2. Materials and Methods
2.1. Implementation of the Clinical Framework
2.2. Molecular Genetic Analyses
2.3. Establishment of a PCR Validation Assay for a RAD51D Deletion
2.4. Data Analysis and Visualization
3. Results
3.1. Familial Breast and Ovarian Cancer Center Greifswald
3.2. Clinical Genetic Testing
3.2.1. Individuals with Fulfilled Inclusion Criteria
3.2.2. Patients with TNBC in the 50-to-59 Age Group
3.2.3. Variants of Unknown Significance (VUS)
3.2.4. Predictive and Diagnostic Genetic Analyses for At-Risk Family Members
3.3. Selected Family Report: Pathogenic BRCA2 and RAD51D Variants in an HBOC Family
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Felbor, U.; Bülow, R.; Schmutzler, R.K.; Rath, M. Hereditary Breast and Ovarian Cancer Service in Sparsely Populated Western Pomerania. Healthcare 2022, 10, 2021. https://doi.org/10.3390/healthcare10102021
Felbor U, Bülow R, Schmutzler RK, Rath M. Hereditary Breast and Ovarian Cancer Service in Sparsely Populated Western Pomerania. Healthcare. 2022; 10(10):2021. https://doi.org/10.3390/healthcare10102021
Chicago/Turabian StyleFelbor, Ute, Robin Bülow, Rita K. Schmutzler, and Matthias Rath. 2022. "Hereditary Breast and Ovarian Cancer Service in Sparsely Populated Western Pomerania" Healthcare 10, no. 10: 2021. https://doi.org/10.3390/healthcare10102021