Abstract
In this paper, we consider the following two-dimensional chemotaxis system of attraction–repulsion with indirect signal production
where the parameters and non-negative initial data . We prove the global bounded solution exists when the attraction is more dominant than the repulsion in the case of . At the same time, we propose that when the radial solution satisfies , the global solution is bounded. During the proof process, we found that adding indirect signals can constrict the blow-up of the global solution.
Keywords:
Keller–Segel; attraction–repulsion model; indirect signal production; radial solution; boundedness MSC:
35B65; 35Q35; 35Q92; 92C17
1. Introduction
The chemotactic model was proposed by Keller and Segel in [1] to describe the movement mechanism of organisms, cells or bacteria under the action of chemicals. Classified based on the direction of movement, we have chemotactic attraction and chemotactic repulsion. These forces play a crucial role in many development systems. In recent years, the issue of chemotaxis has been extensively studied. For example, global solvability has been studied in [2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24], large time behavior in [6,25,26,27,28,29], finite time blow-up in [6,30,31,32,33,34,35,36], nontrivial stationary solutions in [18,37,38,39,40], nonlinear diffusion in [41,42], indirect signaling in [43,44,45,46,47], etc. These studies provide important assistance for us to gain a deeper understanding of chemotactic phenomena.
A classical chemotaxis model is described as follows:
where and denote cell density and chemical concentration, respectively. is a domain and . When is bounded, we propose the homogeneous Neumann initial boundary value conditions:
When , we give the initial data
These equations are used to describe the phenomenon of chemotactic aggregation. However, many biological processes also involve chemotactic repulsion. In [48], Luca proposed a more general model to describe attraction and repulsion phenomena as follows:
If the chemicals diffuse much more rapidly than the movement of cells, the case where can be considered as an approximate version of the case where . Rigorous proof of this limiting process can be found in [49]. For , Jiu and Liu in [50] considered a balanced case. For , Shi and Wang in [6] found that the system (1) has unique non-negative solutions locally in time for initial data satisfying
The non-negative solutions exist globally in time and are bounded in the repulsion-dominant . Nagai and Yamada investigated the case in [5].
Based on the motivation of indirect signal influence, we hope to see that the addition of an indirect signal does not damage the solution of the original system. In the real world, systems can be influenced by other signals at any time. Therefore, we consider the following indirect signal model:
We suppose that the initial data satisfy
Our main result is stated as follows:
Theorem 1.
Let and assume that . Then, we have
for all .
Theorem 2.
Let and assume that non-negative initial data are radial and . Then, we have
for all .
Remark 1.
Because , we have
Thus, the constriction of initial data for becomes weaker.
Remark 2.
Using the Duhamel’s principle in (2), we denote the solution as
where is the heat kernel, and
Here, denotes the inverse pseudo-differential operator of , and we represent it using Fourier and inverse Fourier transformations. That is,
where is the Bessel kernel. We also denote the fractional-order differential operator by
For more detailed related information, please refer to [51,52].
Applying the following Young’s inequality of convolution
and the estimates
we can obtain the Lemma 2 below.
2. Preliminaries
Before giving an energy estimate, we need to utilize the following important mass conservation properties.
Lemma 1.
Proof.
Lemma 2.
For , we have
In particular, the following holds
According to Lemma 2.3 in [5], we have
Lemma 3.
If the non-negative function , it holds that
According to Lemma 2.1 of [53], we have the following lemma.
Lemma 4.
If the non-negative function , it holds that
where ε is any positive number and tends to infinity as .
3. A Prior Estimate
Lemma 5.
Let and assume that . Then,
Proof.
Multiplying the first equation of (2) with and noting , we have
where is small enough to be determined.
On the other hand, we multiply the third equation of (2) with and use the Young’s inequality to obtain
Adding the Equations (11) and (12), we have
Let . Thus, we add the two sides of the Equation (13) with and apply the inequality to obtain
Applying Lemmas 2 and 3 as to (14) yields the following:
Thanks to , we can take a small enough value of such that
Using Gronwall’s inequality, we have
Therefore, we complete the proof of Lemma 5. □
Next, we will give the gradient estimates of .
Lemma 6.
Let and assume holds. We have the following estimate
Proof.
Multiplying the first equation of (2) with and integrating by parts, we can deduce that
We multiply the third equation of (2) by and apply the Young’s inequality yielding
Combining (16) and (17), we have
Next, we take in (18) to obtain
Applying the estimate (10), we have
where is a positive constant.
For the term , we use the Lemma 4 to obtain
Thus, substituting (20) and (21) into (19) yields
We can use the Gagliardo–Nirenberg inequality and Young’s inequality to obtain
Taking a suitable value of such that , then substituting (23) into (22), we have
for all .
Applying Gronwall’s inequality in (24), we show that
where is a constant depending on .
Taking in (18), we can obtain
To control , we use the Gagliardo–Nirenberg inequality and Young’s inequality to deduce
where has yet to be determined. Using the estimate (10) again, there exist a constant such that
Taking the appropriate such that , we can obtain
for all , where depends on and . Similarly to (23), there is a constant such that
Combining (28) with (29) and applying Gronwall’s inequality yields
where depends on .
In what follows, we will give the boundedness of and w.
Lemma 7.
Assume holds. Then, for any , we have
where the constant C depends on and .
Proof.
To obtain the estimate of u, we first employ an energy inequality and Moser’s iteration technique. Next, we utilize the ODE comparison principle and classical elliptic theory to derive the estimates of w and .
Recalling (16) and (2), we integrate by parts for the right-hand side and use Young’s inequality to obtain
That is,
On the other hand, we can use the Gagliardo–Nirenberg inequality to deduce
Substituting (33) into (32) gives
Using Gronwall’s inequality, we have
Let . This yields
where is a constant.
Taking and applying the above iterative inequality, we see that
By virtue of (34) and the boundedness of , we have
Recalling (17) and applying interpolation inequality and Young’s inequality, we further have
This means that
where is a constant independent of p. Applying Gronwall’s inequality and the Lemma 2.1 in [29], we obtain
Letting , we can obtain the boundedness of . Finally, we use the classical elliptic estimate to obtain
Applying the boundedness of w in (37), the proof is complete. □
Proof of Theorem 1.
By virtue of Lemma 6 and Lemma 7 being complete, we complete the proof of the Theorem 1. □
4. Boundedness of Radial Solutions
In this section, we focus on the case of radial solutions. We assume that the non-negative initial data are radially symmetric with respect to the spatial variable x and satisfy (3). We redefine the function and as
and the initial data as . We denote the following:
and .
Similarly to Lemma 1, we have
and
as well as
Lemma 8.
If the spatial variable x is a radial region and U is defined by (38), it holds that
Proof.
By straightforward calculations, we have
and
Therefore, we obtain
and
as well as
Integrating both sides of (2) from 0 to s and combining (43)–(45) yields
Applying the second equations of (2) and (43), we can deduce
Similarly to (46), integrating both sides of (47), we see that
Substituting (48) into (46), we have
Using the third equation of (2) again, we can solve the ODE to obtain
So, we can integrate the both sides of (50) to obtain
Combining (49) and (51) and using the first mean-value theorem and , we have
It means that
Therefore, we complete the proof of Lemma 8. □
Recalling (31), regarding the construction of iterative techniques, we need to By virtue of (48) and , we have
Lemma 9.
Suppose that the spatial variable is a radial region and holds. Then, we have
Proof.
First, for the term , applying the Hölder’s inequality, the estimate of (10) and (41), we deduce that
For convenience, taking the operator , we can obtain the equivalent form
Next, we define a comparison function G(s) as , where and R are two positive constants. Let . That is,
We can take a value that is suitably large such that
Through a direct calculation, we can obtain
Therefore, we have the following gradient flow
Applying the comparison principle, we have
Thus, applying (51), we see that
Noticing (53) and applying (54) and (60), we complete the proof of Lemma 9. □
Proof of Theorem 2.
Thanks to the results obtained from Lemmas 8 and 9, and by employing the iterative technique described in Lemma 7, we complete the proof of Theorem 2. □
Author Contributions
J.W. contributed methods, ideas and writing; Y.H. was responsible for checking and revising the manuscript. All authors have read and agreed to the published version of the manuscript.
Funding
J. Wu was supported by Scientific Research Funds of Chengdu University under grant No. 2081921030, which also was supported funding of the Visual Computing and Virtual Reality Key Laboratory of Sichuan Province under grant No. SCVCVR2023.09VS.
Data Availability Statement
Data are contained within the article.
Conflicts of Interest
The authors declare no conflicts of interest.
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