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Proteomes 2018, 6(2), 23; https://doi.org/10.3390/proteomes6020023

Virophages and Their Interactions with Giant Viruses and Host Cells

Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Ahmed Zewail Road, October Gardens, 6th of October City, Giza 12566, Egypt
Received: 1 March 2018 / Revised: 15 April 2018 / Accepted: 17 May 2018 / Published: 22 May 2018
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Abstract

Virophages are small dsDNA viruses that were first isolated in association with some giant viruses (GVs), and then found in metagenomics samples. They encode about 20–34 proteins. Some virophages share protein similarity with Maverick/Polinton transposons or are considered as a provirophage, whereas about half of the protein’s repertoire remain of unknown function. In this review, we aim to highlight the current understanding of the biology of virophages, as well as their interactions with giant viruses and host cells. Additionally, the virophage proteomes were analyzed to find the functional domains that distinguish each virophage. This bioinformatics analysis will benefit further experimental investigations to understand the protein-protein interactions between virophages, giant viruses, and host cells. View Full-Text
Keywords: giant viruses; virophage; nucleocytoplasmic large DNA viruses (NCLDVs); protein-protein interactions; post translational modifications giant viruses; virophage; nucleocytoplasmic large DNA viruses (NCLDVs); protein-protein interactions; post translational modifications
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Sobhy, H. Virophages and Their Interactions with Giant Viruses and Host Cells. Proteomes 2018, 6, 23.

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