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Technologies
Volume 13
Issue 11
10.3390/technologies13110532
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Integrating Advanced Neuro-Oncology Imaging into Guideline-Directed Multimodal Therapy for Brain Metastases: Evaluating Comparative Treatment Effectiveness

by
Keren Rouvinov
1,2,†,
Rashad Naamneh
2,3,†,
Wenad Najjar
4,
Mahmoud Abu Amna
5,
Arina Soklakova
6,
Ez El Din Abu Zeid
2,
Fahmi Abu Ghalion
2,
Ali Abu Juma’a
2,
Mohnnad Asla
2,
Alexander Yakobson
1,2,‡ and
Walid Shalata
1,2,*,‡
1
The Legacy Heritage Cancer Center, Dr. Larry Norton Institute, Soroka Medical Center, Beer-Sheva 84105, Israel
2
Faculty of Health Sciences, Goldman Medical School, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel
3
Neurosurgery Department, Soroka Medical Center, Beer-Sheva 84105, Israel
4
Neurosurgery Department, Hadassah Hebrew University Medical Center, Jerusalem 91200, Israel
5
Department of Oncology, The Emek Medical Centre, Afula 18341, Israel
6
Faculty of Health Sciences, Medical School for International Health, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
‡
These authors also contributed equally to this work.
Technologies 2025, 13(11), 532; https://doi.org/10.3390/technologies13110532 (registering DOI)
Submission received: 17 October 2025 / Revised: 16 November 2025 / Accepted: 18 November 2025 / Published: 18 November 2025
Versions Notes

Abstract

Background: Brain metastases (BM) are a common and serious complication in cancer patients, particularly those with lung, breast, or melanoma primaries. As systemic therapies extend survival, the incidence of BM has increased, necessitating improved diagnostic and treatment strategies. Recent advances in neuroimaging and therapy have significantly enhanced the ability to diagnose and manage these lesions with greater precision. Methods: This article summarizes current diagnostic imaging modalities—Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), Perfusion-Weighted Imaging (PWI), and Magnetic Resonance Spectroscopy (MRS) and their roles in distinguishing tumor progression from treatment effects. It also compares the efficacy of therapeutic options including Whole-Brain Radiation Therapy (WBRT), Stereotactic Radiosurgery (SRS), and systemic therapies such as targeted drugs and immunotherapies. Outcomes were evaluated based on local tumor control and overall survival. Results: Advanced imaging techniques like PWI, MRS, and PET improve diagnostic accuracy by providing functional and metabolic information beyond standard MRI. Therapeutically, SRS offers better local control and fewer cognitive side effects than WBRT for patients with limited metastases. Targeted and immune-based therapies have shown improved survival in patients with specific genetic mutations, supporting a personalized treatment approach. Conclusions: The integration of advanced imaging and individualized therapies has improved diagnosis, treatment decisions, and outcomes in patients with brain metastases. Ongoing research is essential to refine these tools and approaches, further optimizing patient care and quality of life. 
Keywords: brain metastases; magnetic resonance imaging; positron emission tomography; stereotactic radiosurgery; targeted therapies; immunotherapies brain metastases; magnetic resonance imaging; positron emission tomography; stereotactic radiosurgery; targeted therapies; immunotherapies

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MDPI and ACS Style

Rouvinov, K.; Naamneh, R.; Najjar, W.; Abu Amna, M.; Soklakova, A.; Abu Zeid, E.E.D.; Ghalion, F.A.; Abu Juma’a, A.; Asla, M.; Yakobson, A.; et al. Integrating Advanced Neuro-Oncology Imaging into Guideline-Directed Multimodal Therapy for Brain Metastases: Evaluating Comparative Treatment Effectiveness. Technologies 2025, 13, 532. https://doi.org/10.3390/technologies13110532

AMA Style

Rouvinov K, Naamneh R, Najjar W, Abu Amna M, Soklakova A, Abu Zeid EED, Ghalion FA, Abu Juma’a A, Asla M, Yakobson A, et al. Integrating Advanced Neuro-Oncology Imaging into Guideline-Directed Multimodal Therapy for Brain Metastases: Evaluating Comparative Treatment Effectiveness. Technologies. 2025; 13(11):532. https://doi.org/10.3390/technologies13110532

Chicago/Turabian Style

Rouvinov, Keren, Rashad Naamneh, Wenad Najjar, Mahmoud Abu Amna, Arina Soklakova, Ez El Din Abu Zeid, Fahmi Abu Ghalion, Ali Abu Juma’a, Mohnnad Asla, Alexander Yakobson, and et al. 2025. "Integrating Advanced Neuro-Oncology Imaging into Guideline-Directed Multimodal Therapy for Brain Metastases: Evaluating Comparative Treatment Effectiveness" Technologies 13, no. 11: 532. https://doi.org/10.3390/technologies13110532

APA Style

Rouvinov, K., Naamneh, R., Najjar, W., Abu Amna, M., Soklakova, A., Abu Zeid, E. E. D., Ghalion, F. A., Abu Juma’a, A., Asla, M., Yakobson, A., & Shalata, W. (2025). Integrating Advanced Neuro-Oncology Imaging into Guideline-Directed Multimodal Therapy for Brain Metastases: Evaluating Comparative Treatment Effectiveness. Technologies, 13(11), 532. https://doi.org/10.3390/technologies13110532

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