Next Article in Journal
Assessing Pharmacists’ Preferences towards Efficacy Attributes of Disease-Modifying Therapies in Relapsing-Remitting Multiple Sclerosis
Next Article in Special Issue
The Role of Community Pharmacists in the Detection of Clinically Relevant Drug-Related Problems in Chronic Kidney Disease Patients
Previous Article in Journal / Special Issue
Contrasting PTH Response of Denosumab Use in Dialysis Patients: A Report of 2 Cases
Open AccessArticle

Relationship between 2-Hour Tacrolimus Concentrations and Clinical Outcomes in Long Term Kidney Transplantation

Department of Pharmacy, UC San Diego Health System, 200 West Arbor Dr., San Diego, CA 92103, USA
Division of Clinical Pharmacy, UC San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, CA 92093, USA
Division of Nephrology, Department of Medicine, UC San Diego School of Medicine, La Jolla, CA 92093, USA
Author to whom correspondence should be addressed.
Pharmacy 2020, 8(2), 60;
Received: 12 February 2020 / Revised: 1 April 2020 / Accepted: 2 April 2020 / Published: 3 April 2020
(This article belongs to the Special Issue Pharmacokinetics of Drugs and Dosing in Kidney Disease)
Background: Tacrolimus is routinely monitored using trough concentrations, however, recent data have suggested that area under the curve (AUC) provides better correlation with toxicity and efficacy. Area under the curve is cumbersome to measure, but studies have demonstrated that surrogate time points such as 2-hour concentrations are well correlated with AUC. Methods: This is a single center, retrospective study of adult kidney transplant recipients with 2-hour tacrolimus concentrations measured over three years post-transplant. The primary outcome was to determine the difference in serum creatinine (Scr) in those with 2-hour tacrolimus concentrations greater than 20 ng/mL versus those less than or equal to 20 ng/mL. Results: A total of 150 kidney transplant recipients were included. The mean Scr and glomerular filtration rate were 1.49 ± 1.01 mg/dL and 59 ± 23.2 ml/min/1.73 m2, respectively, for the entire cohort. The rate of donor specific antibody formation was 2% and 8% experienced biopsy-proven rejection. The rate of cytomegalovirus viremia was 2% and BK viremia was 13%. There was no significant difference in kidney function over 36 months for the groups specified a priori. Conclusions: Long-term outcomes of maintaining tacrolimus 2-hour concentrations over 20 ng/mL is favorable with minimal opportunistic infections. View Full-Text
Keywords: tacrolimus; kidney transplantation; drug monitoring tacrolimus; kidney transplantation; drug monitoring
Show Figures

Figure 1

MDPI and ACS Style

Yin, J.; Hsu, T.; Kerr, J.S.; Steiner, R.; Awdishu, L. Relationship between 2-Hour Tacrolimus Concentrations and Clinical Outcomes in Long Term Kidney Transplantation. Pharmacy 2020, 8, 60.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop