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Pharmacy 2017, 5(2), 31;

Investigating the Relative Significance of Drug-Related Problem Categories

The Danish Research Unit for Hospital Pharmacy, Amgros I/S, 2100 Copenhagen, Denmark
The Hospital Pharmacy, Region Zealand, 4700 Næstved, Denmark
The Hospital Pharmacy, Central Denmark Region, 8000 Aarhus, Denmark
Author to whom correspondence should be addressed.
Academic Editor: Keith A. Wilson
Received: 14 March 2017 / Revised: 24 April 2017 / Accepted: 6 June 2017 / Published: 9 June 2017
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The aim of the review was to investigate whether an assessment of clinical significance can be related to specific drug-related problems (DRPs) and hence may assist in prioritizing individual categories of DRP categorization systems. The literature search using Google Scholar was performed for the period 1990 to 2013 and comprised primary research studies of clinical pharmacy interventions including DRP and clinical significance assessments. Two reviewers assessed the titles, abstracts, and full-text papers individually, and inclusion was determined by consensus. A total of 27 unique publications were included in the review. They had been conducted in 14 different countries and reported a large range of DRPs (71–5948). Five existing DRP categorisation systems were frequently used, and two methods employed to assess clinical significance were frequently reported. The present review could not establish a consistent relation between the DRP categories and the level of clinical significance. However, the categories “ADR” and possibly “Drug interaction” were often associated with an assessed high clinical significance, albeit they were infrequently identified in the studies. Hence, clinical significance assessments do not seem to be useful in prioritizing individual DRPs in the DRP categorization systems. Consequently, it may be necessary to reconsider our current approach for evaluating DRPs. View Full-Text
Keywords: drug-related problems; clinical significance; review; categorisation systems; hospital drug-related problems; clinical significance; review; categorisation systems; hospital

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Kjeldsen, L.J.; Nielsen, T.R.H.; Olesen, C. Investigating the Relative Significance of Drug-Related Problem Categories. Pharmacy 2017, 5, 31.

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