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Volume 14
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10.3390/plants14132010
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Review

Antioxidant, Anti-Inflammatory, and Antiapoptotic Effects of Euterpe oleracea Mart. (Açaí) in Improving Cognition Deficits: Potential Therapeutic Implications for Alzheimer’s Disease

by
Flávia dos Santos Ferreira
1,
Juliana Lucena Azevedo de Mattos
1,
Paula Hosana Fernandes da Silva
2,
Cristiane Aguiar da Costa
1,
Dayane Teixeira Ognibene
1,
Angela de Castro Resende
1 and
Graziele Freitas de Bem
1,*
1
Department of Pharmacology and Psychobiology, Roberto Alcantara Gomes Biology Institute (IBRAG), Rio de Janeiro State University (UERJ), Rio de Janeiro 20551-030, RJ, Brazil
2
Department of Pharmacology, Institute of Biomedical Science, University of Sao Paulo (USP), São Paulo 05508-000, SP, Brazil
*
Author to whom correspondence should be addressed.
Plants 2025, 14(13), 2010; https://doi.org/10.3390/plants14132010
Submission received: 23 May 2025 / Revised: 18 June 2025 / Accepted: 28 June 2025 / Published: 30 June 2025
(This article belongs to the Topic Research on Natural Products of Medical Plants)
Review Reports Versions Notes

Abstract

Euterpe oleracea Martius, also popularly known as açaí palm, is a palm tree of the Aracaceae family widely found in the Amazon region. Traditional plant use reports indicate the beneficial effects of açaí juice on fever, pain, and flu. Moreover, many studies have demonstrated the pharmacological potential of açaí, mainly the pulp and seed of the fruit, due to its chemical composition, which significantly consists of polyphenols. In recent years, there has been a growing interest in investigating the neuroprotective effects of açaí, with the potential for the prevention and treatment of neurodegenerative diseases, such as Alzheimer’s disease, mainly due to the increasing aging of the population that has contributed to the increase in the number of individuals affected by this disease that has no cure. Therefore, this review aims to evaluate the potential role of açaí fruit in preventing or treating cognitive deficits, highlighting its potential in Alzheimer’s disease therapy. Preclinical in vivo and in vitro pharmacological studies were utilized to investigate the learning and memory effects of the pulp and seed of the açaí fruit, focusing on antioxidant, anti-inflammatory, antiapoptotic, and autophagy restoration actions.
Keywords: Euterpe oleracea; açaí pulp; açaí seed; neuroprotection; Alzheimer’s disease Euterpe oleracea; açaí pulp; açaí seed; neuroprotection; Alzheimer’s disease

Share and Cite

MDPI and ACS Style

Ferreira, F.d.S.; Mattos, J.L.A.d.; Silva, P.H.F.d.; Costa, C.A.d.; Ognibene, D.T.; Resende, A.d.C.; Bem, G.F.d. Antioxidant, Anti-Inflammatory, and Antiapoptotic Effects of Euterpe oleracea Mart. (Açaí) in Improving Cognition Deficits: Potential Therapeutic Implications for Alzheimer’s Disease. Plants 2025, 14, 2010. https://doi.org/10.3390/plants14132010

AMA Style

Ferreira FdS, Mattos JLAd, Silva PHFd, Costa CAd, Ognibene DT, Resende AdC, Bem GFd. Antioxidant, Anti-Inflammatory, and Antiapoptotic Effects of Euterpe oleracea Mart. (Açaí) in Improving Cognition Deficits: Potential Therapeutic Implications for Alzheimer’s Disease. Plants. 2025; 14(13):2010. https://doi.org/10.3390/plants14132010

Chicago/Turabian Style

Ferreira, Flávia dos Santos, Juliana Lucena Azevedo de Mattos, Paula Hosana Fernandes da Silva, Cristiane Aguiar da Costa, Dayane Teixeira Ognibene, Angela de Castro Resende, and Graziele Freitas de Bem. 2025. "Antioxidant, Anti-Inflammatory, and Antiapoptotic Effects of Euterpe oleracea Mart. (Açaí) in Improving Cognition Deficits: Potential Therapeutic Implications for Alzheimer’s Disease" Plants 14, no. 13: 2010. https://doi.org/10.3390/plants14132010

APA Style

Ferreira, F. d. S., Mattos, J. L. A. d., Silva, P. H. F. d., Costa, C. A. d., Ognibene, D. T., Resende, A. d. C., & Bem, G. F. d. (2025). Antioxidant, Anti-Inflammatory, and Antiapoptotic Effects of Euterpe oleracea Mart. (Açaí) in Improving Cognition Deficits: Potential Therapeutic Implications for Alzheimer’s Disease. Plants, 14(13), 2010. https://doi.org/10.3390/plants14132010

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