Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview
Abstract
:1. Introduction
2. Materials and Methods
3. Diabetic Burden and Its Impact on the Health and Economy of Ecuador
4. Medicinal Plants with Antidiabetic Potential Used in the Traditional Medicine of Ecuador
5. Bioactive Compounds of Ecuadorian Medicinal Plants and Their Anti-Diabetic Properties
6. Conclusions and Future Perspectives
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Family | Scientific Name | Local Name (Vernacular Name) | Plant Part Used | Traditional Preparations | Antidiabetic Activity | References | |
---|---|---|---|---|---|---|---|
In Vitro | In Vivo | ||||||
Acanthaceae | Justicia colorata (Nees) Wassh. | Insulina | Leaf, stem | Infusion | Methanolic extract showed α-glucosidase inhibitory activity with an IC50 value of 622.1 μg/mL where acarbose was used as a positive control, with an IC50 value of 964.6 μg/mL. | - | [26] |
Apiaceae | Foeniculum vulgare Mill. | Hinojo, eneldo | Whole plant | Infusion | Aqueous leaf extract F. vulgare showed free-radicals scavenging activity with an IC50 value of 43 μg/mL, whereas synthetic antioxidant BHT showed an IC50 value of 22.67 μg/mL. | Aqueous leaf extract F. vulgare at a dose of 10 mg/kg reduced the blood glucose level in both normal and streptozotocin-induced diabetic rats. Also, it improved oral glucose tolerance in diabetic rats and revealed a positive effect on liver histology | [56,57,94] |
Neonelsonia acuminata (Benth.) J.M. Coult. and Rose ex Drude | Zanahoria blanca | Root | Eaten raw | Methanolic extract showed α-glucosidase inhibitory activity with an IC50 value of 198.7 μg/mL where acarbose was used as a positive control, with an IC50 value of 964.6 μg/mL. | - | [23,26] | |
Aquifoliaceae | Ilex guayusa Loes. | Guayusa | Leaf | Infusion | Methanolic extract showed α-glucosidase inhibitory activity with an IC50 value of 176.5 μg/mL where acarbose was used as a positive control, with an IC50 value of 964.6 μg/mL. | - | [26,61] |
Asteraceae | Baccharis genistelloides (Lam.) Pers. | Tres filos | Aerial part | Aqueous infusion | Methanolic extract showed α-glucosidase inhibitory activity with an IC50 value of 154.6 μg/mL where acarbose was used as a positive control, with an IC50 value of 964.6 μg/mL. | - | [26,51,95] |
Matricaria chamomilla L. | Chamomile | Whole plant | Infusion | - | Ethanolic extract of M. chamomilla was introduced in streptozotocin-induced diabetic rats at doses of 5, 20, 50, and 100 mg/kg. Treatment with varying doses of MCE notably mitigated postprandial hyperglycemia and oxidative stress, bolstering the antioxidant system, while safeguarding pancreatic islet cells in histological examinations as compared to the control group. | [63,64] | |
Convolvulaceae | Ipomoea carnea Jacq. | Borrachera, matacabra | Aerial part | Infusion | - | Hot, cold, aqueous, and alcoholic extracts of I. carnea leaves were introduced to streptozotocin-induced diabetic Wistar rats at a dose rate of 500 mg/kg body weight. The results indicated that the alcoholic extract had more potential to lower blood glucose and lipid levels in diabetic rats. | [34,62] |
Costaceae | Costus comosus Roscoe | Caña | Stem | Decoction | Methanolic extract showed α-glucosidase inhibitory activity with an IC50 value of 57.9 μg/mL whereas acarbose was used as positive control, with an IC50 value of 964.6 μg/mL. | - | [26,51] |
Costus villosissimus Jacq. | Caña agria | Leaf, stem | Infusion | Not elucidated | Not elucidated | [82] | |
Crassulaceae | Bryophyllum gastonis-bonnieri (Raym.-Hamet and H. Perrier) Lauz.-March. | Dulcamara | Leaf | Juice, crushed | Not elucidated | Not elucidated | [59,81] |
Euphorbiaceae | Croton wagneri Müll.Arg. | Moshquera | Leaf | Aqueous infusion | Methanolic extract showed α-glucosidase and α-amylase inhibitory activities with IC50 values of 162.4 μg/mL and more than 1000 μg/mL, respectively, where acarbose was used as a positive control, with IC50 values of 964.6 μg/mL and 56.8 μg/mL, respectively. | - | [26,34,62] |
Fabaceae | Cajanus cajan (L.) Millsp. | Fréjol de palo | Bark | Infusion | - | The antidiabetic activity of C. cajan methanolic extract was evaluated in alloxan-induced diabetic Swiss albino mice at doses of 200 and 400 mg/kg body weight, respectively. The results indicate a significant decrease in fasting serum glucose level and a reduction in blood glucose level during a 5 day study, as observed in the alloxan-induced diabetic mice. | [34,54] |
Geraniaceae | Pelargonium graveolens L’Hér. | Esencia de rosa | Flower, leaf, stem | Infusion | The essential oil of P. graveolens leaves showed α-glucosidase inhibitory activity with an IC50 value of 93.72 μg/mL, whereas acarbose was used as the positive control with an IC50 value of 80.4 μg/mL. | - | [23,68] |
Juglandaceae | Juglans neotropica Diels | Nogal, tocte | Leaf | Infusion | Not elucidated | Not elucidated | [34] |
Lauraceae | Persea americana Mill. | Aguacate | Leaf, fruit, seed | Aqueous infusion, decoction | Aqueous extract of P. americana seed exhibited α-glucosidase and α-amylase inhibitory activities at 56.41% and 21.42%, respectively, whereas the positive control acarbose exhibited inhibitory activities of 76.41% for both enzymes. | Aqueous extracts of P. americana seed were administered to DM-induced male Wistar rats at a dose of 26.7, 53.3, and 106.6 mg/kg body weights, respectively. The results indicated a decrease in fasting blood glucose levels as well as TG, LDL-c, G6P, F-1, 6-BP, MDA, IL-6, TNF-α, and NF-ĸB. An increase in liver glycogen, hexokinase, and HDL-c was indicated. | [24,51,70] |
Leguminosae | Glycyrrhiza glabra L. | Zaragoza | Leaf, stem | Infusion | - | Ethanolic extract of G. glabra roots was introduced to streptozotocin-induced diabetic rats at doses of 200 mg/kg and 400 mg/kg, respectively. The results indicate a significant reduction of fasting blood glucose and fasting serum insulin in diabetic rats. | [25,59,60] |
Myroxylon peruiferum L.f. | Bálsamo, chaquino | Bark | Infusion | Not elucidated | Not elucidated | [34] | |
Mimosaceae | Pithecellobium excelsum (Kunth) Mart. | Chaquiro | Bark | Infusion | Not elucidated | Not elucidated | [34] |
Monimiaceae | Siparuna eggersii Hieron. | Monte del oso | Leaf | Crushed, infusion | Methanolic extract showed α-glucosidase inhibitory activity with an IC50 value of 28.3 μg/mL where acarbose was used as a positive control, with an IC50 value of 964.6 μg/mL. | - | [26,51] |
Moraceae | Artocarpus altilis (Parkinson) Fosberg | Fruto del pan | Leaf | Aqueous infusion | Methanolic extract showed α-glucosidase inhibitory activity with an IC50 value of 40.9 μg/mL where acarbose was used as a positive control, with an IC50 value of 964.6 μg/mL. | - | [26,51,52] |
Piperaceae | Piper crassinervium Kunth | Guabiduca | Stem, leaf | Decoction | Methanolic extract showed α-glucosidase inhibitory activity with an IC50 value of 108.5 μg/mL where acarbose was used as a positive control, with an IC50 value of 964.6 μg/mL. | - | [26,51] |
Proteaceae | Oreocallis grandiflora R.Br. | Cucharillo | Leaf, bark, flower | Aqueous infusion | Methanolic extract showed α-glucosidase and α-amylase inhibitory activities with IC50 values of 2.8 μg/mL and 161.5 μg/mL, respectively, where acarbose was used as a positive control with IC50 values of 964.6 μg/mL and 56.8 μg/mL, respectively. | - | [23,26,51] |
Pteridaceae | Adiantum poiretii Wikstr. | Culantrillo | Aerial part | Aqueous infusion | Methanolic extract showed α-glucosidase inhibitory activity with an IC50 value of 46.3 μg/mL where acarbose was used as a positive control with an IC50 value of 964.6 μg/mL. | - | [23,26,51] |
Rutaceae | Ruta graveolens L. | Ruda | Stem, leaf | Infusion | Methanolic and chloroform extracts of R. graveolens showed α-glucosidase and α-amylase inhibitory activities with IC50 values of 281 and 460.5 μg/mL, and 215 and 479 μg/mL, respectively, whereas acarbose showed inhibitory activities of 484.2 and 69.7 μg/mL, respectively. | - | [75] |
Solanaceae | Physalis peruviana L. | Uvilla, uchuva, uvilla lanuda | Fruit | Juice | - | Aqueous decoctions of P. peruviana leaf powder were administrated to guinea pigs at the dose range of 100 mg/kg to 3.2 g/kg of body weight. The dose of 100 mg/kg of aqueous extract induced a significant reduction of glucose but at doses exceeding 400 mg, alterations in blood, kidney, and liver markers were noted, with mortality observed at doses above 800 mg/kg and LD50 of approximately 1280 mg/kg was obtained. | [23,72,73] |
Urticaceae | Urtica dioica L. | Ortiga | Whole plant | Infusion, fresh | - | Aqueous extract of U. dioica (250 mg/kg) showed a strong glucose-lowering effect in alloxan-induced diabetic rats. The decrease of glycemia has reached 33% of the control value 1 h after glucose loading. | [79,96] |
Verbenaceae | Verbena litoralis Kunth | Verbena | Whole plant | Cooked, infusion | Methanolic extract showed α-glucosidase inhibitory activity with an IC50 value of 337.9 μg/mL where acarbose was used as a positive control, with an IC50 value of 964.6 μg/mL. | - | [26,97] |
Scientific Name | Bioactive Compounds with Antidiabetic Properties | Bioactive Chemical Group | Antidiabetic Properties | Reference |
---|---|---|---|---|
Adiantum poiretii | No proper evidence found | - | - | - |
Artocarpus altilis | n-Hexadecanoic acid | Fatty acid | α-amylase and α-glucosidase inhibitory activity and antioxidant activity | [122] |
Ellagic acid | Phenol | α-amylase inhibitory activity and antioxidant activity, stimulate insulin secretion and decrease glucose intolerance | [134] | |
2-Heptadecenal | Aldehyde | α-amylase and α-glucosidase inhibitory activity | [124] | |
Baccharis genistelloides | Cirsimaritin | Flavonoid | Reduces elevated levels of serum glucose in diabetic rats and abrogates the increase in serum insulin | [100] |
Cirsiliol | Flavonoid | Hypoglycaemic effect | [101] | |
Hispidulin | Flavonoid | Stimulates glucagon-like peptide-1 and suppresses hepatic glucose production | [102] | |
Genkwanin | Flavonoid | α-amylase inhibitory activity and antioxidant activity | [103] | |
Apigenin | Flavonoid | Facilitates glucose-stimulated insulin secretion and prevents ER stress-mediated β-cell apoptosis in the pancreas | [104] | |
Bryophyllum gastonis-bonnieri | Quercetin | Flavonoid | Reduces serum glucose in a dose-dependent fashion. | [135] |
Fisetin | Flavonoid | Improves blood glucose homeostasis, lowers methylglyoxal-dependent protein glycation, and mitigates diabetes-related complications. | [136] | |
Caffeic acid | Phenol | Reduces hepatic glucose output and enhances adipocyte glucose uptake, insulin secretion, and antioxidant capacity | [113] | |
Ferulic acid | Phenol | Improves insulin sensitivity and hepatic glycogenesis, also inhibits gluconeogenesis and maintains insulin signalling to maintain normal glucose homeostasis. | [112] | |
Cajanus cajan | Betulinic acid | Terpenoid | Reduces blood glucose, α-amylase and improves insulin sensitivity as well as pancreas histopathology | [137] |
Pinostrobin | Flavonoid | Reduces the blood sugar level of diabetic mice | [138] | |
Genistein | Flavonoid | Inhibits hepatic glucose production, increases β-cell proliferation, reduces β-cell apoptosis, and shows antioxidant activity | [139] | |
Costus comosus | Camphene | Monoterpene | Reduces fasting blood sugar and blood insulin levels. | [140] |
n-Hexadecanoic acid | Fatty acid | α-amylase and α-glucosidase inhibitory and antioxidant activities | [122] | |
Costus villosissimus | Not known | Not known | ||
Croton wagneri | Myrcene | Monoterpene | α-amylase and α-glucosidase inhibitory activities | [141] |
Foeniculum vulgare | Trans-anethole | Phenylpropanoid | Suppresses diabetic nephropathy in rats by decreasing blood glucose levels and downregulating AT1R and TGF-β1 expressions | [110] |
Fenchone | Monoterpenoid | Protects against increased blood glucose levels and decreased levels of antioxidant enzyme activities in alloxan-induced diabetic rats | [142] | |
Estragole | Phenylpropene | α-amylase and lipase inhibitory activity, antioxidant activity | [127] | |
Methyl chavicol | Phenylpropene | α-amylase and tyrosinase inhibitory activity, antioxidant activity | [128] | |
Limonene | Monoterpene | Inhibits protein glycation, stimulates the uptake of glucose and breakdown of fats, upregulates glucose transporter 1 (GLUT1) expression, and suppresses α-amylase and α-glucosidase | [143] | |
α-Phellandrene | Monoterpene | Increases glucose uptake, enhances glycerol-3-phosphate activity and triglyceride accumulation, and regulates adipositic function | [144] | |
Glycyrrhiza glabra | Glycyrrhizin | Saponin | Reduce blood insulin levels and improve tolerance to oral glucose loading and oxidative stress. | [25] |
n-Hexadecanoic acid | Fatty acid | α-amylase and α-glucosidase inhibitory activities and antioxidant activity | [122] | |
Dodecanoic acid | Fatty acid | Decreases fasting blood glucose level and induces β-cell regeneration in diabetic rat | [123] | |
Carvone | Terpenoid | Improves glycoprotein components and controls glucose metabolism | [145] | |
Ilex guayusa | Chlorogenic acid | Phenol | Increases glucose uptake in L6 muscular cells and raises insulin secretion from the INS-1E insulin-secreting cell line and rat islets of Langerhans. | [111] |
Quercetin-3-O-hexose | Flavonoid | Inhibits the activity of glucose transporter, enhances glucose uptake, reduces hepatic glucose production, protects against pancreatic islet beta-cell, α-glucosidase inhibition | [146] | |
Ipomoea carnea | Spathulenol | Sesquiterpenoid | Strong antioxidant, α-amylase, and α-glucosidase inhibitory activities | [147] |
Caryophyllene oxide | Sesquiterpene | α-amylase and α-glucosidase inhibitory activities and antioxidant activity | [148] | |
Juglans neotropica | Holocellulose | Polysaccharide | Acts as an activator for glucokinase in reducing blood sugar | [131] |
Lignin | Organic polymer | Improves inhibitory effect on α-amylase activity, antioxidant activity | [132] | |
Justicia colorata | No proper evidence found | - | - | - |
Matricaria chamomilla | Germacrene D | Sesquiterpene | Strong inhibitor of α-glucosidase | [143] |
Myroxylon peruiferum | Germacrene D | Sesquiterpene | Strong inhibitor of α-glucosidase | [143] |
α-Pinene | Terpene | Inhibition of α-amylase | [149] | |
Spathulenol | Sesquiterpenoid | Strong antioxidant, α-amylase, and α-glucosidase inhibitory activities | [147] | |
Caryophyllene oxide | Sesquiterpene | α-amylase and α-glucosidase inhibitory activity and antioxidant activity | [148] | |
Limonene | Monoterpene | Inhibits protein glycation, stimulates the uptake of glucose and breakdown of fats, upregulates the glucose transporter 1 (GLUT1) expression, and suppresses α-amylase and α-glucosidase | [150] | |
Neonelsonia acuminata | No proper evidence found | - | - | - |
Oreocallis grandiflora | Myricetin 3-O-β-glucuronide | Flavonoid | Stimulates 2-deoxy-glucose uptake in C2C12 myocytes | [151] |
Isorhamnetin hexuronide | Flavonoid | Decreases glucose level and oxidative stress, modulates lipid metabolism and adipocytic activity | [152] | |
Quercetin 3-O-rutinoside | Flavonoid | Regulates whole-body glucose homeostasis; reduces intestinal glucose absorption, insulin secretion, and insulin-sensitizing actions; and enhances glucose utilization in peripheral tissues | [153] | |
Quercetin 3-O-β-glucuronide | Flavonoid | Stimulates 2-deoxy-glucose uptake in C2C12 myocytes | [151] | |
Isorhamnetin hexoside | Flavonoid | Decreases glucose levels and oxidative stress, modulates lipid metabolism and adipocytic activity | [153] | |
Isorhamnetin 3-O-rutinoside | Flavonoid | Decreases glucose level and oxidative stress, modulates lipid metabolism and adipocytic activity | [153] | |
Pelargonium graveolens | Chlorogenic acid | Phenol | Increases glucose uptake in L6 muscular cells and raises insulin secretion from the INS-1E insulin-secreting cell line and rat islets of Langerhans. | [111] |
Quercetin-3-O-hexose | Flavonoid | Inhibits the activity of glucose transporter, enhances glucose uptake, reduces hepatic glucose production, protects against pancreatic islet beta-cell, and inhibits α-glucosidase | [146] | |
Persea americana | β-Caryophyllene | Sesquiterpene | Exhibits selective agonism on cannabinoid receptor type 2 (CB2R), which plays a role in glucose and lipid metabolism, antioxidant, anti-inflammatory activities | [154] |
Caryophyllene oxide | Sesquiterpene | α-amylase and α-glucosidase inhibitory activities and antioxidant activity | [148] | |
α-Humulene | Sesquiterpene | Prevents oxidative stress through the reduction mechanism of 8-hydroxy-2-deoksiguanosin in the pancreatic β-cells | [145] | |
Catechin | Sesquiterpenoid | Reduces blood sugar source, regulates intestinal functions, improves insulin resistance, and has antioxidant and anti-inflammatory activities | [155] | |
Caffeic acid | Phenol | Reduces hepatic glucose output and enhances adipocyte glucose uptake, insulin secretion, and antioxidant capacity | [113] | |
Chlorogenic acid | Phenol | Increases glucose uptake in L6 muscular cells and raises insulin secretion from the INS-1E insulin-secreting cell line and rat islets of Langerhans. | [111] | |
Coumaric acid | Phenol | Lowers the blood glucose level and gluconeogenic enzymes and increases the activities of hexokinase, glucose-6 phosphatase dehydrogenase, and GSH via increasing levels of insulin. | [97] | |
Ferulic acid | Phenol | Improves insulin sensitivity and hepatic glycogenesis, inhibits gluconeogenesis, and maintains insulin signalling to maintain normal glucose homeostasis. | [112] | |
Physalis peruviana | Phytol | Diterpenoid | Stimulates insulin resistance by activation of nuclear receptors and heterodimerization of RXR with PPARγ | [156] |
n-Hexacosane | Alkane | Improves blood glucose, glucose tolerance, glycated hemoglobin, and liver glycogen | [129] | |
Piper crassinervium | Germacrene D | Sesquiterpene | Strong inhibitor of α-glucosidase | [143] |
β-Caryophyllene | Sesquiterpene | Exhibits selective agonism on cannabinoid receptor type 2 (CB2R), which plays a role in glucose and lipid metabolism, antioxidant, and anti-inflammatory activities. | [154] | |
Spathulenol | Sesquiterpenoid | Strong antioxidant, α-amylase, and α-glucosidase inhibitory activities | [147] | |
Pithecellobium excelsum | No proper evidence found | - | - | - |
Ruta graveolens | No proper evidence found | - | - | - |
Siparuna eggersii | Germacrene D | Sesquiterpene | Strong inhibitor of α-glucosidase | [143] |
Caryophyllene oxide | Sesquiterpene | α-amylase and α-glucosidase inhibitory activities and antioxidant activity | [148] | |
Urtica dioica | Carvacrol | Monoterpenoid | Improves diabetes-related enzymes, insulin resistance, insulin sensitivity, glucose uptake, and antioxidant and anti-inflammatory activities. | [157] |
Carvone | Monoterpenoid | Improves glycoprotein components and controls glucose metabolism | [158] | |
Naphthalene | Polycyclic aromatic hydrocarbon | α-glucosidase inhibitory activity | [133] | |
(E)-Anethole | Phenylpropanoid | Suppresses diabetic nephropathy in rats by decreasing blood glucose levels and downregulating AT1R and TGF-β1 expressions. | [126] | |
Hexahydrofarnesyl acetone | Sesquiterpene | α-glucosidase inhibition activity | [159] | |
(E)-β-Ionone | Sesquiterpenoid | α-amylase and α-glucosidase inhibitory activities and antioxidant activity | [160] | |
Phytol | Diterpene | Stimulates insulin resistance by activation of nuclear receptors and heterodimerization of RXR with PPARγ | [156] | |
Verbena litoralis | Chlorogenic acid | Phenol | Increases glucose uptake in L6 muscular cells and raises insulin secretion from the INS-1E insulin-secreting cell line and rat islets of langerhans. | [111] |
Caffeic acid | Phenol | Reduction of hepatic glucose output and enhances adipocyte glucose uptake, insulin secretion, and antioxidant capacity | [113] | |
Apigenin | Flavonoid | Facilitates glucose-stimulated insulin secretion and prevents ER stress-mediated β-cell apoptosis in the pancreas | [104] | |
p-Coumaric acid | Phenol | Lowers the blood glucose level and gluconeogenic enzymes and increases the activities of hexokinase, glucose-6 phosphatase dehydrogenase, and GSH via increasing the level of insulin. | [97] | |
Vanillic acid | Phenol | Reduces hyperglycemia and GSH and increases liver enzymes found in diabetic rats, anti-inflammatory activity | [114] | |
Ferulic acid | Phenol | Improves insulin sensitivity and hepatic glycogenesis, also inhibits gluconeogenesis, and maintains insulin signalling to maintain normal glucose homeostasis. | [112] |
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Bhattacharya, S.; Gupta, N.; Flekalová, A.; Gordillo-Alarcón, S.; Espinel-Jara, V.; Fernández-Cusimamani, E. Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview. Plants 2024, 13, 1436. https://doi.org/10.3390/plants13111436
Bhattacharya S, Gupta N, Flekalová A, Gordillo-Alarcón S, Espinel-Jara V, Fernández-Cusimamani E. Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview. Plants. 2024; 13(11):1436. https://doi.org/10.3390/plants13111436
Chicago/Turabian StyleBhattacharya, Soham, Neha Gupta, Adéla Flekalová, Salomé Gordillo-Alarcón, Viviana Espinel-Jara, and Eloy Fernández-Cusimamani. 2024. "Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview" Plants 13, no. 11: 1436. https://doi.org/10.3390/plants13111436