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Article

Untargeted Phenolic Profiling and Functional Insights of the Aerial Parts and Bulbs of Drimia maritima (L.) Stearn

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Department for Sustainable Food Process, Università Cattolica del Sacro Cuore, Via Emilia Parmense 84, 29122 Piacenza, Italy
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Department of Biology, Science Faculty, Selcuk University, Konya 42130, Turkey
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Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit 80837, Mauritius
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Deparment of Biotechnology, Science Faculty, Selcuk University, Konya 42130, Turkey
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Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, Universidade de Vigo, E-32004 Ourense, Spain
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Department of Agriculture, University of Naples Federico II, 80138 Naples, Italy
*
Authors to whom correspondence should be addressed.
Academic Editors: Asunción Amorós and Petko Denev
Plants 2022, 11(5), 600; https://doi.org/10.3390/plants11050600
Received: 27 January 2022 / Revised: 20 February 2022 / Accepted: 21 February 2022 / Published: 23 February 2022
Drimia maritima (L.) Stearn (squill), belonging to the Asparagaceae family, is acknowledged as a medicinally valuable species from the Drimia genera. In this study, water, methanol, and ethyl acetate extracts of D. maritima aerial parts and bulbs were investigated for their polyphenols profile and evaluated for their antioxidant and enzyme inhibition properties. Phenolics were profiled through an untargeted metabolomics approach using an ultra-high pressure liquid chromatograph coupled to quadrupole-time-of-flight mass spectrometry (UHPLC-QTOF-MS). This analysis revealed an enrichment of low molecular weight phenolics and flavonoids in the aerial parts of D. maritima, while lignans mainly characterized bulb extracts. Antioxidant capacity was investigated by different assays, including phosphomolybdenum assays, radical scavenging (DPPH: 2,2-diphenyl-1-picrylhydrazyl; ABTS: 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)), as well as reducing ability (CUPRAC: cupric reducing antioxidant capacity; FRAP: ferric reducing antioxidant power), and metal chelating. In radical scavenging and reducing power assays, the water extract of aerial parts exhibited the strongest ability (DPPH: 36.99 mg trolox equivalent (TE)/g; ABTS: 85.96 mg TE/g; CUPRAC: 87.37 mg TE/g; FRAP: 55.43 mg TE/g). In general, the ethyl acetate extracts from aerial parts and bulbs provided the weakest antioxidant capacity. Concerning enzyme inhibitory activities, the water extracts of the bulb were poorly active, while the ethyl acetate extracts from both plant portions displayed the best α-amylase inhibitory abilities. The best acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) abilities were recorded by ethyl acetate extract of aerial parts (2.36 mg galantamine equivalent (GALAE)/g) and bulbs (5.10 mg GALAE/g), respectively. Overall, these results support the medicinal aptitude of D. maritima and its possible use as a natural source of antioxidants and enzyme inhibitors with functional potential. View Full-Text
Keywords: metabolomics; antioxidants; enzyme inhibition; multivariate analysis; polyphenols metabolomics; antioxidants; enzyme inhibition; multivariate analysis; polyphenols
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MDPI and ACS Style

Zhang, L.; Zengin, G.; Mahomoodally, M.F.; Yıldıztugay, E.; Jugreet, S.; Simal-Gandara, J.; Rouphael, Y.; Pannico, A.; Lucini, L. Untargeted Phenolic Profiling and Functional Insights of the Aerial Parts and Bulbs of Drimia maritima (L.) Stearn. Plants 2022, 11, 600. https://doi.org/10.3390/plants11050600

AMA Style

Zhang L, Zengin G, Mahomoodally MF, Yıldıztugay E, Jugreet S, Simal-Gandara J, Rouphael Y, Pannico A, Lucini L. Untargeted Phenolic Profiling and Functional Insights of the Aerial Parts and Bulbs of Drimia maritima (L.) Stearn. Plants. 2022; 11(5):600. https://doi.org/10.3390/plants11050600

Chicago/Turabian Style

Zhang, Leilei, Gokhan Zengin, Mohamad Fawzi Mahomoodally, Evren Yıldıztugay, Sharmeen Jugreet, Jesus Simal-Gandara, Youssef Rouphael, Antonio Pannico, and Luigi Lucini. 2022. "Untargeted Phenolic Profiling and Functional Insights of the Aerial Parts and Bulbs of Drimia maritima (L.) Stearn" Plants 11, no. 5: 600. https://doi.org/10.3390/plants11050600

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