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Open AccessFeature PaperReview

Biomimetic Approaches to the Synthesis of Natural Disesquiterpenoids: An Update

1
Department of Pharmaceutical Sciences, University of Piemonte Orientale, L.go Donegani 2/3, 28100 Novara, Italy
2
PlantaChem srls, via Canobio 4/6, 28100 Novara, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Igor Jerković
Plants 2021, 10(4), 677; https://doi.org/10.3390/plants10040677
Received: 20 March 2021 / Revised: 30 March 2021 / Accepted: 30 March 2021 / Published: 1 April 2021
Natural disesquiterpenoids represent a small group of secondary metabolites characterized by complex molecular scaffolds and interesting pharmacological profiles. In the last decade, more than 400 new disesquiterpenoids have been discovered and fully characterized, pointing out once more the “magic touch” of nature in the design of new compounds. The perfect blend of complex and unique architectures and biological activity has made sesquiterpene dimers an attractive and challenging synthetic target, inspiring organic chemists to find new and biomimetic approaches to replicate the efficiency and the selectivity of natural processes under laboratory conditions. In this work, we present a review covering the literature from 2010 to 2020 reporting all the efforts made in the total synthesis of complex natural disesquiterpenoids. View Full-Text
Keywords: natural compounds; secondary metabolites; disesquiterpenoids; bioactive compounds natural compounds; secondary metabolites; disesquiterpenoids; bioactive compounds
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MDPI and ACS Style

Caprioglio, D.; Salamone, S.; Pollastro, F.; Minassi, A. Biomimetic Approaches to the Synthesis of Natural Disesquiterpenoids: An Update. Plants 2021, 10, 677. https://doi.org/10.3390/plants10040677

AMA Style

Caprioglio D, Salamone S, Pollastro F, Minassi A. Biomimetic Approaches to the Synthesis of Natural Disesquiterpenoids: An Update. Plants. 2021; 10(4):677. https://doi.org/10.3390/plants10040677

Chicago/Turabian Style

Caprioglio, Diego; Salamone, Stefano; Pollastro, Federica; Minassi, Alberto. 2021. "Biomimetic Approaches to the Synthesis of Natural Disesquiterpenoids: An Update" Plants 10, no. 4: 677. https://doi.org/10.3390/plants10040677

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