Developmental Aspects of SARS-CoV-2, Potential Role of Exosomes and Their Impact on the Human Transcriptome
Abstract
:1. Introduction
2. Emergence of SARS-CoV-2 and Relation to Other CoVs
2.1. General Description of Genes and Proteins
2.2. Replication Cycle from Entry to Egress
3. SARS-CoV-2 Infection and Immunity in Pregnancy and Fetal Development
3.1. Impact of COVID-19 on Fetal Development and Children
3.2. SARS-CoV-2 and Fetal Development: The Role of Exosomes
3.3. Development and Functions of Exosomes: Biogenesis and Biology
3.4. Genomic, Transcriptomic, Proteomic, and Lipidomic Landscape of Exosomes
4. SARS-CoV-2 Infection and Exosomal Pathway
4.1. Does SARS-CoV-2 Hijack the Exosomal Pathway for Cellular Entry and Exit?
4.2. Entry of SARS-CoV-2 and Exosomes in Cells
4.3. Exit of SARS-CoV-2 and Exosomes from Cells
5. RNA-Based Analysis of COVID-19 Patients
5.1. Transcriptomic Analysis of Placental Cells in the Context of COVID-19
5.2. Transcriptome of Children Affected with COVID-19
5.3. Host Transcriptional Profiles and COVID-19 Pathogenesis
5.4. Host Transcriptomic Profiles and T Cell Behavior
5.5. Host Lung and Colon Transcriptomes Show Elevated Neutrophil Extracellular Traps and TGF-β Response, Respectively
5.6. Insights from Single-Cell Transcriptome of SARS-CoV-2 Infection in African Green Monkeys
5.7. Lessons from the SARS-CoV-2 Transcriptome
6. RNA-Based Approach to Combat COVID-19
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Clinical Trial Identifier | Intervention | Description |
---|---|---|
NCT04368728 | BNT162b1 | Lipid-nanoparticle-formulated, nucleoside-modified mRNA vaccine, encodes trimerized RBD of S protein of SARS-CoV-2 |
NCT04847050 | mRNA-1273 | Lipid nanoparticle–encapsulated mRNA-based vaccine, encodes prefusion-stabilized full length S protein of SARS-CoV-2 |
NCT04889209 | Ad26.COV2.S | Recombinant, replication-incompetent human adenovirus type 26 vector encoding prefusion-stabilized full-length S protein of SARS-CoV-2 |
NCT04516746 | ChAdOx1 nCoV-19 (AZD1222) | Replication-deficient simian adenovirus vector ChAdOx1 + full-length S protein SARS-CoV-2 |
NCT04834869 | BBV152 | Whole-virion inactivated, formulated with toll-like receptor 7/8 agonist adsorbed to alum |
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Dogra, N.; Ledesma-Feliciano, C.; Sen, R. Developmental Aspects of SARS-CoV-2, Potential Role of Exosomes and Their Impact on the Human Transcriptome. J. Dev. Biol. 2021, 9, 54. https://doi.org/10.3390/jdb9040054
Dogra N, Ledesma-Feliciano C, Sen R. Developmental Aspects of SARS-CoV-2, Potential Role of Exosomes and Their Impact on the Human Transcriptome. Journal of Developmental Biology. 2021; 9(4):54. https://doi.org/10.3390/jdb9040054
Chicago/Turabian StyleDogra, Navneet, Carmen Ledesma-Feliciano, and Rwik Sen. 2021. "Developmental Aspects of SARS-CoV-2, Potential Role of Exosomes and Their Impact on the Human Transcriptome" Journal of Developmental Biology 9, no. 4: 54. https://doi.org/10.3390/jdb9040054
APA StyleDogra, N., Ledesma-Feliciano, C., & Sen, R. (2021). Developmental Aspects of SARS-CoV-2, Potential Role of Exosomes and Their Impact on the Human Transcriptome. Journal of Developmental Biology, 9(4), 54. https://doi.org/10.3390/jdb9040054