An Evolutionarily Conserved Network Mediates Development of the zona limitans intrathalamica, a Sonic Hedgehog-Secreting Caudal Forebrain Signaling Center
Abstract
:1. Introduction
2. The Zli: A Unique Shh-Expressing Compartment in the Caudal Forebrain
2.1. Forebrain Morphology and Zli Positioning
2.2. Shh Expression Initiates and Demarcates Zli Development
2.3. Physical Separation: The Zli as a Tissue Compartment
3. A Role for Wnt Ligands in Generating a Zli-Permissive Compartment
4. Laying the Ground for the zli: Otx2 and Barhl2 Binding to cis-Regulatory Sequences Confers Competence for zli Formation
5. Hedgehog Sequential Induction Process in zli Formation: Shh Is a Secreted Signal Read out through a Primary Cilium
5.1. Shh Maturation and Secretion
5.2. The Shh Signal Is Read through a Primary Cilium
6. Building Compartments: The Iroquois Genes Refine the Zli Borders
7. Sticking Together: GRNs and Signaling Pathways Modulate Zli Cell Differential Adhesive Properties and Proliferation Rate
7.1. Canonical Wnt Signaling Regulates Thalamic Cell Adhesiveness and Segregation
7.2. The Notch/Delta Pathway Contributes to Correct Separation of the Zli and Thalamic Fields
7.3. The TFs Barhl2 and Irx Facilitate Acquisition of Zli Compartment Properties
8. The Programming of A “Zli-Like” Structure in X. laevis Animal Cap Explants Confirms Otx2, Barhl2 and Iroquois Cell Autonomous and Non-Autonomous Activities in Zli Formation
9. Inductive Cues and Zli Positioning: A Role for the p2/p3 Border and for Fezf/Fez TFs
10. The GRN Involved in Zli Formation is Evolutionarily Conserved
11. Forebrain Malformations Associated with Defects in the GRN and Signaling Pathways Supporting Zli Formation
12. Conclusions
Acknowledgments
Conflicts of Interest
References
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Sena, E.; Feistel, K.; Durand, B.C. An Evolutionarily Conserved Network Mediates Development of the zona limitans intrathalamica, a Sonic Hedgehog-Secreting Caudal Forebrain Signaling Center. J. Dev. Biol. 2016, 4, 31. https://doi.org/10.3390/jdb4040031
Sena E, Feistel K, Durand BC. An Evolutionarily Conserved Network Mediates Development of the zona limitans intrathalamica, a Sonic Hedgehog-Secreting Caudal Forebrain Signaling Center. Journal of Developmental Biology. 2016; 4(4):31. https://doi.org/10.3390/jdb4040031
Chicago/Turabian StyleSena, Elena, Kerstin Feistel, and Béatrice C. Durand. 2016. "An Evolutionarily Conserved Network Mediates Development of the zona limitans intrathalamica, a Sonic Hedgehog-Secreting Caudal Forebrain Signaling Center" Journal of Developmental Biology 4, no. 4: 31. https://doi.org/10.3390/jdb4040031