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Inhibition of SERPINE1 Function Attenuates Wound Closure in Response to Tissue Injury: A Role for PAI-1 in Re-Epithelialization and Granulation Tissue Formation

Roles of Antioxidative Enzymes in Wound Healing

Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata 990-9585, Japan
Authors to whom correspondence should be addressed.
Academic Editor: Robin C. Muise-Helmericks
J. Dev. Biol. 2015, 3(2), 57-70;
Received: 30 December 2014 / Revised: 4 April 2015 / Accepted: 21 April 2015 / Published: 27 April 2015
(This article belongs to the Special Issue Wound Healing and Tissue Regeneration)
Since skin is the first barrier separating the body from the external environment, impaired wound healing can be life threatening to living organisms. Delayed healing processes are observed in animals under certain circumstances, such as advanced age, diabetes, and immunosuppression, but the underlying mechanisms of the abnormality remain elusive. Redox homeostasis is defined as the balance between the levels of reactive oxygen species (ROS) and antioxidants in which antioxidative enzymes play central roles in scavenging ROS. In addition to deleterious effects, ROS also exert beneficial functions on some cellular processes such as transducing phosphorylation signaling, but excessive antioxidants may impede the healing process. Hence, strict control over the amounts of antioxidants is desirable when applied for therapeutic purposes. Here we overview recent findings regarding the relationships between antioxidative enzymes and wound healing. Unveiling the role of antioxidative enzymes is expected to contribute to our understanding of the wound healing processes. View Full-Text
Keywords: cutaneous wound healing; reactive oxygen species; antioxidative enzyme; redox balance cutaneous wound healing; reactive oxygen species; antioxidative enzyme; redox balance
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MDPI and ACS Style

Kurahashi, T.; Fujii, J. Roles of Antioxidative Enzymes in Wound Healing. J. Dev. Biol. 2015, 3, 57-70.

AMA Style

Kurahashi T, Fujii J. Roles of Antioxidative Enzymes in Wound Healing. Journal of Developmental Biology. 2015; 3(2):57-70.

Chicago/Turabian Style

Kurahashi, Toshihiro, and Junichi Fujii. 2015. "Roles of Antioxidative Enzymes in Wound Healing" Journal of Developmental Biology 3, no. 2: 57-70.

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