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Gangliosides: The Double-Edge Sword of Neuro-Ectodermal Derived Tumors

Université de Lille, CNRS, UMR8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, F59000 Lille, France
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Biomolecules 2019, 9(8), 311; https://doi.org/10.3390/biom9080311
Received: 25 June 2019 / Revised: 25 July 2019 / Accepted: 26 July 2019 / Published: 27 July 2019
(This article belongs to the Special Issue Bioactive Lipids in Health and Disease)
Gangliosides, the glycosphingolipids carrying one or several sialic acid residues, are mostly localized at the plasma membrane in lipid raft domains and implicated in many cellular signaling pathways mostly by interacting with tyrosine kinase receptors. Gangliosides are divided into four series according to the number of sialic acid residues, which can be also modified by O-acetylation. Both ganglioside expression and sialic acid modifications can be modified in pathological conditions such as cancer, which can induce either pro-cancerous or anti-cancerous effects. In this review, we summarize the specific functions of gangliosides in neuro-ectodermal derived tumors, and their roles in reprogramming the lipidomic profile of cell membrane occurring with the induction of epithelial-mesenchymal transition. View Full-Text
Keywords: gangliosides; cancer; signal transduction; epithelial-mesenchymal transition; therapy gangliosides; cancer; signal transduction; epithelial-mesenchymal transition; therapy
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Cavdarli, S.; Groux-Degroote, S.; Delannoy, P. Gangliosides: The Double-Edge Sword of Neuro-Ectodermal Derived Tumors. Biomolecules 2019, 9, 311.

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