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The Contribution of the 20S Proteasome to Proteostasis

Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Biomolecules 2019, 9(5), 190; https://doi.org/10.3390/biom9050190
Received: 12 April 2019 / Revised: 7 May 2019 / Accepted: 12 May 2019 / Published: 16 May 2019
(This article belongs to the Special Issue The Broader Cellular Impact of Proteasome-CSN-eIf3 (PCI) Complexes)
The last decade has seen accumulating evidence of various proteins being degraded by the core 20S proteasome, without its regulatory particle(s). Here, we will describe recent advances in our knowledge of the functional aspects of the 20S proteasome, exploring several different systems and processes. These include neuronal communication, post-translational processing, oxidative stress, intrinsically disordered protein regulation, and extracellular proteasomes. Taken together, these findings suggest that the 20S proteasome, like the well-studied 26S proteasome, is involved in multiple biological processes. Clarifying our understanding of its workings calls for a transformation in our perception of 20S proteasome-mediated degradation—no longer as a passive and marginal path, but rather as an independent, coordinated biological process. Nevertheless, in spite of impressive progress made thus far, the field still lags far behind the front lines of 26S proteasome research. Therefore, we also touch on the gaps in our knowledge of the 20S proteasome that remain to be bridged in the future. View Full-Text
Keywords: protein degradation; 20S proteasome; cellular homeostasis; oxidative stress; intrinsically disordered proteins; neuronal communication protein degradation; 20S proteasome; cellular homeostasis; oxidative stress; intrinsically disordered proteins; neuronal communication
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MDPI and ACS Style

Kumar Deshmukh, F.; Yaffe, D.; Olshina, M.A.; Ben-Nissan, G.; Sharon, M. The Contribution of the 20S Proteasome to Proteostasis. Biomolecules 2019, 9, 190. https://doi.org/10.3390/biom9050190

AMA Style

Kumar Deshmukh F, Yaffe D, Olshina MA, Ben-Nissan G, Sharon M. The Contribution of the 20S Proteasome to Proteostasis. Biomolecules. 2019; 9(5):190. https://doi.org/10.3390/biom9050190

Chicago/Turabian Style

Kumar Deshmukh, Fanindra, Dana Yaffe, Maya A. Olshina, Gili Ben-Nissan, and Michal Sharon. 2019. "The Contribution of the 20S Proteasome to Proteostasis" Biomolecules 9, no. 5: 190. https://doi.org/10.3390/biom9050190

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