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Biomolecules 2019, 9(2), 80;

Mechanisms of Spindle Positioning: Lessons from Worms and Mammalian Cells

Department of Microbiology and Cell Biology (MCB), Indian Institute of Science (IISc), Bangalore 560012, India
Received: 8 January 2019 / Revised: 13 February 2019 / Accepted: 18 February 2019 / Published: 25 February 2019
(This article belongs to the Special Issue Cytoskeleton and Regulation of Mitosis)
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Proper positioning of the mitotic spindle is fundamental for specifying the site for cleavage furrow, and thus regulates the appropriate sizes and accurate distribution of the cell fate determinants in the resulting daughter cells during development and in the stem cells. The past couple of years have witnessed tremendous work accomplished in the area of spindle positioning, and this has led to the emergence of a working model unravelling in-depth mechanistic insight of the underlying process orchestrating spindle positioning. It is evident now that the correct positioning of the mitotic spindle is not only guided by the chemical cues (protein–protein interactions) but also influenced by the physical nature of the cellular environment. In metazoans, the key players that regulate proper spindle positioning are the actin-rich cell cortex and associated proteins, the ternary complex (Gα/GPR-1/2/LIN-5 in Caenorhabditis elegans, Gαi/Pins/Mud in Drosophila and Gαi1-3/LGN/NuMA in humans), minus-end-directed motor protein dynein and the cortical machinery containing myosin. In this review, I will mainly discuss how the abovementioned components precisely and spatiotemporally regulate spindle positioning by sensing the physicochemical environment for execution of flawless mitosis. View Full-Text
Keywords: mitosis; microtubules; spindle positioning; actin cytoskeleton; NuMA; dynein; myosin mitosis; microtubules; spindle positioning; actin cytoskeleton; NuMA; dynein; myosin

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Kotak, S. Mechanisms of Spindle Positioning: Lessons from Worms and Mammalian Cells. Biomolecules 2019, 9, 80.

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