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Open AccessCommunication

Lnc-EPB41-Protein Interactions Associated with Congenital Pouch Colon

Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research (BISR), Statue Circle, Jaipur 302021, India
Department of Biotechnology, Amity University Rajasthan, Kant Kalwar, Jaipur 303002, India
Department of Biotechnology, IIS University, Mansarovar, Jaipur 302020, India
Department of Chemistry, School of Basic Science, Manipal University, Jaipur 303007, India
NanoTemper Technologies, World Trade Centre, Bengaluru 302017, India
Department of Paediatric Surgery, SMS Medical College, JLN Marg, Jaipur 302004, India
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Biomolecules 2018, 8(3), 95;
Received: 21 August 2018 / Revised: 10 September 2018 / Accepted: 13 September 2018 / Published: 17 September 2018
Congenital Pouch Colon (CPC) is a rare anorectal anomaly common to northwestern India, specifically Rajasthan. Despite efforts to understand the clinical genetic makeup of CPC, no attempt on identifying non-coding RNAs was done. We have earlier reported CPC’s rare variants from whole exome sequencing (WES) across 18 affected samples in a total of 64 subjects. A Smith–Waterman algorithm was used to infer a couple of lncRNAs from WES samples of CPC with predictions from the Noncode database. Further screening and quantification using polymerase chain reaction (PCR), we ascertained interactions using Micro Scale Thermophoresis (MST). We report the role of lnc-EPB41-1-1 shown to be promiscuously interacting with KIF13A substantiating their role in regulation. View Full-Text
Keywords: long non coding RNA; whole exome sequencing; protein interaction; congenital pouch colon; microscale thermophoresis long non coding RNA; whole exome sequencing; protein interaction; congenital pouch colon; microscale thermophoresis
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MDPI and ACS Style

Gupta, S.; Gupta, N.; Tiwari, P.; Menon, S.; Mathur, P.; Kothari, S.L.; Nallapeta, S.; Medicherla, K.M.; Suravajhala, P. Lnc-EPB41-Protein Interactions Associated with Congenital Pouch Colon. Biomolecules 2018, 8, 95.

AMA Style

Gupta S, Gupta N, Tiwari P, Menon S, Mathur P, Kothari SL, Nallapeta S, Medicherla KM, Suravajhala P. Lnc-EPB41-Protein Interactions Associated with Congenital Pouch Colon. Biomolecules. 2018; 8(3):95.

Chicago/Turabian Style

Gupta, Sonal; Gupta, Nidhi; Tiwari, Pradeep; Menon, Saji; Mathur, Praveen; Kothari, Shanker L.; Nallapeta, Sivaramaiah; Medicherla, Krishna M.; Suravajhala, Prashanth. 2018. "Lnc-EPB41-Protein Interactions Associated with Congenital Pouch Colon" Biomolecules 8, no. 3: 95.

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