Next Article in Journal
Plasma Membrane Lipid Domains as Platforms for Vesicle Biogenesis and Shedding?
Previous Article in Journal
On Molecular Descriptors of Carbon Nanocones
Open AccessReview

The Biology of Glial Cells and Their Complex Roles in Alzheimer’s Disease: New Opportunities in Therapy

Department of Pharmacy, BRAC University, Dhaka 1212, Bangladesh
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Biomolecules 2018, 8(3), 93; https://doi.org/10.3390/biom8030093
Received: 6 August 2018 / Revised: 28 August 2018 / Accepted: 6 September 2018 / Published: 10 September 2018
Even though Alzheimer’s disease (AD) is of significant interest to the scientific community, its pathogenesis is very complicated and not well-understood. A great deal of progress has been made in AD research recently and with the advent of these new insights more therapeutic benefits may be identified that could help patients around the world. Much of the research in AD thus far has been very neuron-oriented; however, recent studies suggest that glial cells, i.e., microglia, astrocytes, oligodendrocytes, and oligodendrocyte progenitor cells (NG2 glia), are linked to the pathogenesis of AD and may offer several potential therapeutic targets against AD. In addition to a number of other functions, glial cells are responsible for maintaining homeostasis (i.e., concentration of ions, neurotransmitters, etc.) within the central nervous system (CNS) and are crucial to the structural integrity of neurons. This review explores the: (i) role of glial cells in AD pathogenesis; (ii) complex functionalities of the components involved; and (iii) potential therapeutic targets that could eventually lead to a better quality of life for AD patients. View Full-Text
Keywords: glial cells; astrocytes; NG2 glia; microglia; oligodendrocytes; Alzheimer’s disease; neurodegenerative disease; Aβ-peptides glial cells; astrocytes; NG2 glia; microglia; oligodendrocytes; Alzheimer’s disease; neurodegenerative disease; Aβ-peptides
MDPI and ACS Style

Nirzhor, S.S.R.; Khan, R.I.; Neelotpol, S. The Biology of Glial Cells and Their Complex Roles in Alzheimer’s Disease: New Opportunities in Therapy. Biomolecules 2018, 8, 93.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

1
Back to TopTop