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Guardian of Genetic Messenger-RNA-Binding Proteins

Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
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Author to whom correspondence should be addressed.
Academic Editors: Natalia Osna and Kusum Kharbanda
Biomolecules 2016, 6(1), 4; https://doi.org/10.3390/biom6010004
Received: 2 September 2015 / Revised: 2 December 2015 / Accepted: 4 December 2015 / Published: 6 January 2016
(This article belongs to the Collection Multi-Organ Alcohol-Related Damage: Mechanisms and Treatment)
RNA in cells is always associated with RNA-binding proteins that regulate all aspects of RNA metabolism including RNA splicing, export from the nucleus, RNA localization, mRNA turn-over as well as translation. Given their diverse functions, cells express a variety of RNA-binding proteins, which play important roles in the pathologies of a number of diseases. In this review we focus on the effect of alcohol on different RNA-binding proteins and their possible contribution to alcohol-related disorders, and discuss the role of these proteins in the development of neurological diseases and cancer. We further discuss the conventional methods and newer techniques that are employed to identify RNA-binding proteins. View Full-Text
Keywords: RNA-binding proteins; mRNA stability; mRNA splicing; gene expression; alcohol; neurological diseases; cancer RNA-binding proteins; mRNA stability; mRNA splicing; gene expression; alcohol; neurological diseases; cancer
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Anji, A.; Kumari, M. Guardian of Genetic Messenger-RNA-Binding Proteins. Biomolecules 2016, 6, 4.

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