Next Article in Journal
Comparative Studies of Vertebrate Platelet Glycoprotein 4 (CD36)
Next Article in Special Issue
Break-Induced Replication and Genome Stability
Previous Article in Journal
SUMO Wrestles with Recombination
Article Menu

Export Article

Open AccessReview
Biomolecules 2012, 2(3), 376-388;

Sumoylation and the DNA Damage Response

Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
Programs in Biochemistry, Cell, and Molecular Biology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA
Author to whom correspondence should be addressed.
Current address: Mammalian Genetics Lab, Cancer Research UK London Research Institute, London WC2A 3LY, UK
Received: 1 August 2012 / Revised: 23 August 2012 / Accepted: 24 August 2012 / Published: 4 September 2012
(This article belongs to the Special Issue DNA Damage Response)
PDF [680 KB, uploaded 4 September 2012]


The cellular response to DNA damage involves multiple pathways that work together to promote survival in the face of increased genotoxic lesions. Proteins in these pathways are often posttranslationally modified, either by small groups such as phosphate, or by protein modifiers such as ubiquitin or SUMO. The recent discovery of many more SUMO substrates that are modified at higher levels in damage conditions adds weight to the accumulated evidence suggesting that sumoylation plays an important functional role in the DNA damage response. Here we discuss the significance of DNA damage-induced sumoylation, the effects of sumoylation on repair proteins, sumoylation dynamics, and crosstalk with other posttranslational modifications in the DNA damage response. View Full-Text
Keywords: sumoylation; DNA damage response; genome integrity sumoylation; DNA damage response; genome integrity

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Cremona, C.A.; Sarangi, P.; Zhao, X. Sumoylation and the DNA Damage Response. Biomolecules 2012, 2, 376-388.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Biomolecules EISSN 2218-273X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top