Novel Insights into Molecular Mechanisms of Endometrial Diseases
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References
- Siegel, R.L.; Miller, K.D.; Fuchs, H.E.; Jemal, A. Cancer statistics. CA Cancer J. Clin. 2022, 72, 7–33. [Google Scholar] [CrossRef] [PubMed]
- Cancer Research UK Uterine Cancer Incidence Statistics. 2015. Available online: https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/uterine-cancer#heading-Zero (accessed on 15 November 2020).
- Gu, B.; Shang, X.; Yan, M.; Li, X.; Wang, W.; Wang, Q.; Zhang, C. Variations in incidence and mortality rates of endometrial cancer at the global, regional, and national levels, 1990–2019. Gynecol. Oncol. 2021, 161, 573–580. [Google Scholar] [CrossRef] [PubMed]
- Kurman, R.J.; Carcangiu, M.L.; Herrington, C.S. World Health Organisation Classification of Tumours of the Female Reproductive Organs; International Agency for Research on Cancer: Lyon, France, 2014. [Google Scholar]
- Lacey, J.V., Jr.; Sherman, M.E.; Rush, B.B.; Ronnett, B.M.; Ioffe, O.B.; Duggan, M.A.; Glass, A.G.; Richesson, D.A.; Chatterjee, N.; Langholz, B. Absolute Risk of Endometrial Carcinoma During 20-Year Follow-Up Among Women with Endometrial Hyperplasia. J. Clin. Oncol. 2010, 28, 788–792. [Google Scholar] [CrossRef]
- Rakha, E.; Wong, S.C.; Soomro, I.; Chaudry, Z.; Sharma, A.; Deen, S.; Chan, S.; Abu, J.; Nunns, D.; Williamson, K.; et al. Clinical Outcome of Atypical Endometrial Hyperplasia Diagnosed on an Endometrial Biopsy. Am. J. Surg. Pathol. 2012, 36, 1683–1690. [Google Scholar] [CrossRef] [PubMed]
- Doherty, M.T.; Sanni, O.B.; Coleman, H.G.; Cardwell, C.R.; McCluggage, W.G.; Quinn, D.; Wylie, J.; McMenamin, Ú.C. Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis. PLoS ONE 2020, 15, e0232231. [Google Scholar] [CrossRef] [PubMed]
- Coakley, K.; Wolford, J.; Tewari, K.S. Fertility preserving treatment for gynecologic malignancies: A review of recent literature. Curr. Opin. Obstet. Gynecol. 2020, 32, 51–56. [Google Scholar] [CrossRef]
- Corzo, C.; Santillan, N.B.; Westin, S.N.; Ramirez, P.T. Updates on Conservative Management of Endometrial Cancer. Obstet. Gynecol. Surv. 2017, 72, 715–716. [Google Scholar] [CrossRef]
- Cancer Genome Atlas Research Network; Levine, D.A. Integrated genomic characterization of endometrial carcinoma. Nature 2013, 497, 67–73. [Google Scholar] [CrossRef] [Green Version]
- Hussein, Y.R.; Weigelt, B.; Levine, D.A.; Schoolmeester, J.K.; Dao, L.N.; Balzer, B.L.; Liles, G.; Karlan, B.; Köbel, M.; Lee, C.H.; et al. Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations. Mod. Pathol. 2015, 28, 505–514. [Google Scholar] [CrossRef]
- Le Gallo, M.; Bell, D.W. The Emerging Genomic Landscape of Endometrial. Cancer Clin. Chem. 2014, 60, 98–110. [Google Scholar] [CrossRef] [Green Version]
- Talhouk, A.; McConechy, M.K.; Leung, S.; Li-Chang, H.H.; Kwon, J.S.; Melnyk, N.; Yang, W.; Senz, J.; Boyd, N.; Karnezis, A.N.; et al. A clinically applicable molecular-based classification for endometrial cancers. Br. J. Cancer 2015, 113, 299–310. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Hause, R.J.; Pritchard, C.C.; Shendure, J.; Salipante, S.J. Classification and characterization of microsatellite instability across 18 cancer types. Nat. Med. 2016, 22, 1342–1350. [Google Scholar] [CrossRef] [PubMed]
- Zighelboim, I.; Goodfellow, P.J.; Gao, F.; Gibb, R.K.; Powell, M.A.; Rader, J.S.; Mutch, D.G. Microsatellite Instability and Epigenetic Inactivation of MLH1 and Outcome of Patients with Endometrial Carcinomas of the Endometrioid Type. J. Clin. Oncol. 2007, 25, 2042–2048. [Google Scholar] [CrossRef]
- Kuhn, E.; Wu, R.-C.; Guan, B.; Wu, G.; Zhang, J.; Wang, Y.; Song, L.; Yuan, X.; Wei, L.; Roden, R.B.; et al. Identification of Molecular Pathway Aberrations in Uterine Serous Carcinoma by Genome-wide Analyses. Gynecol. Oncol. 2012, 104, 1503–1513. [Google Scholar] [CrossRef] [PubMed]
- Karnezis, A.N.; Leung, S.; Magrill, J.; McConechy, M.K.; Yang, W.; Chow, C.; Kobel, M.; Lee, C.-H.; Huntsman, D.G.; Talhouk, A.; et al. Evaluation of endometrial carcinoma prognostic immunohistochemistry markers in the context of molecular classification. J. Pathol. Clin. Res. 2017, 3, 279–293. [Google Scholar] [CrossRef]
- Zhao, S.; Choi, M.; Overton, J.D.; Bellone, S.; Roque, D.M.; Cocco, E.; Guzzo, F.; English, D.P.; Varughese, J.; Gasparrini, S.; et al. Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma. Proc. Natl. Acad. Sci. USA 2013, 110, 2916–2921. [Google Scholar] [CrossRef] [Green Version]
- Bogani, G.; Chiappa, V.; Lopez, S.; Salvatore, C.; Interlenghi, M.; D’Oria, O.; Giannini, A.; Maggiore, U.L.R.; Chiarello, G.; Palladino, S.; et al. Radiomics and Molecular Classification in Endometrial Cancer (The ROME Study): A Step Forward to a Simplified Precision Medicine. Healthcare 2022, 10, 2464. [Google Scholar] [CrossRef]
- Talhouk, A.; Hoang, L.N.; McConechy, M.K.; Nakonechny, Q.; Leo, J.; Cheng, A.; Leung, S.; Yang, W.; Lum, A.; Köbel, M.; et al. Molecular classification of endometrial carcinoma on diagnostic specimens is highly concordant with final hysterectomy: Earlier prognostic information to guide treatment. Gynecol. Oncol. 2016, 143, 46–53. [Google Scholar] [CrossRef] [Green Version]
- Di Donato, V.; Iacobelli, V.; Schiavi, M.C.; Colagiovanni, V.; Pecorella, I.; Palaia, I.; Perniola, G.; Marchetti, C.; Musella, A.; Tomao, F.; et al. Impact of hormone receptor status and Ki-67 expression on disease-free survival in patients affected by high-risk endometrial cancer. Int. J. Gynecol. Cancer 2018, 28, 505–513. [Google Scholar] [CrossRef]
- Concin, N.; Matias-Guiu, X.; Vergote, I.; Cibula, D.; Mirza, M.R.; Marnitz, S.; Ledermann, J.; Bosse, T.; Chargari, C.; Fagotti, A.; et al. ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma. Int. J. Gynecol. Cancer 2021, 31, 12–39. [Google Scholar] [CrossRef]
- Petrucci, E.; Pasquini, L.; Bernabei, M.; Saulle, E.; Biffoni, M.; Accarpio, F.; Sibio, S.; Di Giorgio, A.; Di Donato, V.; Casorelli, A.; et al. A Small Molecule SMAC Mimic LBW242 Potentiates TRAIL- and Anticancer Drug-Mediated Cell Death of Ovarian Cancer Cells. PLoS ONE 2012, 7, e35073. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Musacchio, L.; Boccia, S.M.; Caruso, G.; Santangelo, G.; Fischetti, M.; Tomao, F.; Perniola, G.; Palaia, I.; Muzii, L.; Pignata, S.; et al. Immune Checkpoint Inhibitors: A Promising Choice for Endometrial Cancer Patients? J. Clin. Med. 2020, 9, 1721. [Google Scholar] [CrossRef] [PubMed]
- Cuccu, I.; D’Oria, O.; Sgamba, L.; De Angelis, E.; D’Augè, T.G.; Turetta, C.; Di Dio, C.; Scudo, M.; Bogani, G.; Di Donato, V.; et al. Role of Genomic and Molecular Biology in the Modulation of the Treatment of Endometrial Cancer: Narrative Review and Perspectives. Healthcare 2023, 11, 571. [Google Scholar] [CrossRef]
- Vizza, E.; Bruno, V.; Cutillo, G.; Mancini, E.; Sperduti, I.; Patrizi, L.; Certelli, C.; Zampa, A.; Giannini, A.; Corrado, G. Prognostic Role of the Removed Vaginal Cuff and Its Correlation with L1CAM in Low-Risk Endometrial Adenocarcinoma. Cancers 2021, 14, 34. [Google Scholar] [CrossRef] [PubMed]
- Giannini, A.; Di Donato, V.; Schiavi, M.C.; May, J.; Panici, P.B.; Congiu, M.A. Predictors of postoperative overall and severe complications after surgical treatment for endometrial cancer: The role of the fragility index. Int. J. Gynecol. Obstet. 2019, 148, 174–180. [Google Scholar] [CrossRef]
- Di Donato, V.; D’Oria, O.; Giannini, A.; Bogani, G.; Fischetti, M.; Santangelo, G.; Tomao, F.; Palaia, I.; Perniola, G.; Muzii, L.; et al. Age-Adjusted Charlson Comorbidity Index Predicts Survival in Endometrial Cancer Patients. Gynecol. Obstet. Investig. 2022, 87, 191–199. [Google Scholar] [CrossRef]
- D’Oria, O.; D’Augè, T.G.; Baiocco, E.; Vincenzoni, C.; Mancini, E.; Bruno, V.; Chiofalo, B.; Mancari, R.; Vizza, R.; Cutillo, G.; et al. The role of preoperative frailty assessment in patients affected by gynecological cancer: A narrative review. Ital. J. Gynaecol. Obstet. 2022, 34, 76–83. [Google Scholar] [CrossRef]
- Zhang, X.; Chen, D.; Zhao, X.; Wang, C.; He, Y.; Chen, Y.; Wang, J.; Shen, D. Application of molecular classification to guiding fertility-sparing therapy for patients with endometrial cancer or endometrial intraepithelial neoplasia. Pathol. Res. Pract. 2023, 241, 154278. [Google Scholar] [CrossRef] [PubMed]
- Norimatsu, Y.; Moriya, T.; Kobayashi, T.K.; Sakurai, T.; Shimizu, K.; Tsukayama, C.; Ohno, E. Immunohistochemical expression of PTEN and be-ta-catenin for endometrial intraepithelial neoplasia in Japanese women. Ann. Diagn. Pathol. 2007, 11, 103–108. [Google Scholar] [CrossRef]
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Golia D’Augè, T.; Cuccu, I.; Santangelo, G.; Muzii, L.; Giannini, A.; Bogani, G.; Di Donato, V. Novel Insights into Molecular Mechanisms of Endometrial Diseases. Biomolecules 2023, 13, 499. https://doi.org/10.3390/biom13030499
Golia D’Augè T, Cuccu I, Santangelo G, Muzii L, Giannini A, Bogani G, Di Donato V. Novel Insights into Molecular Mechanisms of Endometrial Diseases. Biomolecules. 2023; 13(3):499. https://doi.org/10.3390/biom13030499
Chicago/Turabian StyleGolia D’Augè, Tullio, Ilaria Cuccu, Giusi Santangelo, Ludovico Muzii, Andrea Giannini, Giorgio Bogani, and Violante Di Donato. 2023. "Novel Insights into Molecular Mechanisms of Endometrial Diseases" Biomolecules 13, no. 3: 499. https://doi.org/10.3390/biom13030499