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Article

Increase in Serum MMP-9 and TIMP-1 Concentrations during Alcohol Intoxication in Adolescents—A Preliminary Study

1
Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and Allergology, Medical University of Bialystok, ul. Waszyngtona 17, 15-274 Bialystok, Poland
2
Department of Pediatric Emergency Medicine, Medical University of Bialystok, ul. Waszyngtona 17, 15-274 Bialystok, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Cecilia M. P. Rodrigues
Biomolecules 2022, 12(5), 710; https://doi.org/10.3390/biom12050710
Received: 19 April 2022 / Revised: 10 May 2022 / Accepted: 14 May 2022 / Published: 16 May 2022
Background: Alcohol consumption by adolescents is responsible for a number of adverse health and social outcomes. Despite the well-established effect of alcohol use on the development of alcoholic liver disease, the relationship between the pattern of alcohol consumption and liver fibrosis is still unclear. This study is a follow-up to work on liver damage from alcohol intoxication. The aim of our study was to explore the early effects of alcohol intoxication on liver fibrosis in adolescents. Methods: The prospective study included 57 adolescents aged 14–17 years admitted to the emergency department (ED) from February 2017 to June 2018 due to acute alcohol intoxication. Serum levels of amino terminal propeptide of type III procollagen (PIIINP), type IV collagen, matrix metallopeptidase 9 (MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1) were determined by enzyme-linked immunosorbent assays. Results: There were significant differences in MMP-9 (p = 0.02) and TIMP-1 (p = 0.007) levels between the study and control groups. Liver parameters and selected markers of fibrosis were similar in groups in terms of blood alcohol concentrations (BAC). MMP-9 was positively correlated with alanine aminotransferase (ALT) (r = 0.38; p = 0.004) and total bilirubin (r = 0.39; p = 0.004). Positive significant correlations were also found between TIMP-1 and ALT (r = 0.47; p < 0.001), AST (r = 0.29; p = 0.03) and total bilirubin (r = 0.32; p = 0.02). In receiver operating characteristic (ROC) analysis, MMP-9 (AUC = 0.67, p = 0.02) and TIMP-1 (AUC = 0.69, p = 0.003) allowed for the differentiation of patients with and without alcohol intoxication. Conclusion: Our results show that even a single episode of alcohol intoxication in adolescents can lead to imbalance in markers of fibrosis. View Full-Text
Keywords: liver fibrosis; MMP-9; TIMP-1; ethanol; adolescents liver fibrosis; MMP-9; TIMP-1; ethanol; adolescents
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MDPI and ACS Style

Zdanowicz, K.; Kowalczuk-Kryston, M.; Olanski, W.; Werpachowska, I.; Mielech, W.; Lebensztejn, D.M. Increase in Serum MMP-9 and TIMP-1 Concentrations during Alcohol Intoxication in Adolescents—A Preliminary Study. Biomolecules 2022, 12, 710. https://doi.org/10.3390/biom12050710

AMA Style

Zdanowicz K, Kowalczuk-Kryston M, Olanski W, Werpachowska I, Mielech W, Lebensztejn DM. Increase in Serum MMP-9 and TIMP-1 Concentrations during Alcohol Intoxication in Adolescents—A Preliminary Study. Biomolecules. 2022; 12(5):710. https://doi.org/10.3390/biom12050710

Chicago/Turabian Style

Zdanowicz, Katarzyna, Monika Kowalczuk-Kryston, Witold Olanski, Irena Werpachowska, Wlodzimierz Mielech, and Dariusz M. Lebensztejn. 2022. "Increase in Serum MMP-9 and TIMP-1 Concentrations during Alcohol Intoxication in Adolescents—A Preliminary Study" Biomolecules 12, no. 5: 710. https://doi.org/10.3390/biom12050710

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