Yuanhuacin and Related Anti-Inflammatory and Anticancer Daphnane Diterpenes from Genkwa Flos—An Overview
Abstract
:1. Introduction
2. Yuanhuacin, a Potent Anticancer Agent
3. YC and Analogues. The yuanhuaXin Family (YX)
4. The Flavonoid Yuanhuanin (YN)
5. Conclusions
Funding
Conflicts of Interest
References
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Cellular or Tumor Models | Observed Effects | References |
---|---|---|
Melanoma cells | YC and YD inhibit melanogenesis and B16 melanoma cell proliferation in vitro. | [42] |
Breast cancer model (BC) | BC growth inhibition in vivo (MCF7 model) with a Genkwa Flos extract and characterization of YC | [6] |
Triple-negative breast cancer cell (TNBC), basal-like 2 subtype | Potent activity of YC against the BL2 subtype of TNBC (nM IC50 against HCC1806 and HCC70 cell lines). | [43] |
Human non-small cell lung cancer (NSCLC) | YC inhibits cell growth and actin cytoskeleton organization and reduces tumor growth in vivo (H1993 model). | [40] |
Comparison of YC, YD, YG, YL as inhibitors of A549 cell proliferation. | [39] | |
YC inhibits Lewis lung carcinoma (LLC) growth in mice. | [41] | |
Colon cancer cells | Inhibition of HCT116 cell proliferation and G2/M cell cycle arrest induced by YC, via upregulation of p21 and downregulation of Sp1. | [44] |
Promyelocytic leukemia | YC inhibits proliferation of P-388 and l-1210 murine leukemia cells in vitro. | [38] |
YC inhibits HL-60 cell growth and induces apoptosis. | [41] |
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Bailly, C. Yuanhuacin and Related Anti-Inflammatory and Anticancer Daphnane Diterpenes from Genkwa Flos—An Overview. Biomolecules 2022, 12, 192. https://doi.org/10.3390/biom12020192
Bailly C. Yuanhuacin and Related Anti-Inflammatory and Anticancer Daphnane Diterpenes from Genkwa Flos—An Overview. Biomolecules. 2022; 12(2):192. https://doi.org/10.3390/biom12020192
Chicago/Turabian StyleBailly, Christian. 2022. "Yuanhuacin and Related Anti-Inflammatory and Anticancer Daphnane Diterpenes from Genkwa Flos—An Overview" Biomolecules 12, no. 2: 192. https://doi.org/10.3390/biom12020192