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Review

Biological Treatments for Temporomandibular Joint Disc Disorders: Strategies in Tissue Engineering

1
Centre for Rapid and Sustainable Product Development, Polytechnic of Leiria, 2430-028 Marinha Grande, Portugal
2
Instituto Português da Face, 1050-227 Lisboa, Portugal
3
Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal
*
Authors to whom correspondence should be addressed.
Academic Editor: Inbo Han
Biomolecules 2021, 11(7), 933; https://doi.org/10.3390/biom11070933
Received: 27 May 2021 / Revised: 14 June 2021 / Accepted: 18 June 2021 / Published: 23 June 2021
The temporomandibular joint (TMJ) is an important structure for the masticatory system and the pathologies associated with it affect a large part of the population and impair people’s lifestyle. It comprises an articular disc, that presents low regeneration capacities and the existing clinical options for repairing it are not effective. This way, it is imperative to achieve a permanent solution to guarantee a good quality of life for people who suffer from these pathologies. Complete knowledge of the unique characteristics of the disc will make it easier to achieve a successful tissue engineering (TE) construct. Thus, the search for an effective, safe and lasting solution has already started, including materials that replace the disc, is currently growing. The search for a solution based on TE approaches, which involve regenerating the disc. The present work revises the TMJ disc characteristics and its associated diseases. The different materials used for a total disc replacement are presented, highlighting the TE area. A special focus on future trends in the field and part of the solution for the TMJ problems described in this review will involve the development of a promising engineered disc approach through the use of decellularized extracellular matrices. View Full-Text
Keywords: temporomandibular joint disc; fibrocartilage; disc dysfunctions; tissue engineering; decellularization temporomandibular joint disc; fibrocartilage; disc dysfunctions; tissue engineering; decellularization
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MDPI and ACS Style

Trindade, D.; Cordeiro, R.; José, H.C.; Ângelo, D.F.; Alves, N.; Moura, C. Biological Treatments for Temporomandibular Joint Disc Disorders: Strategies in Tissue Engineering. Biomolecules 2021, 11, 933. https://doi.org/10.3390/biom11070933

AMA Style

Trindade D, Cordeiro R, José HC, Ângelo DF, Alves N, Moura C. Biological Treatments for Temporomandibular Joint Disc Disorders: Strategies in Tissue Engineering. Biomolecules. 2021; 11(7):933. https://doi.org/10.3390/biom11070933

Chicago/Turabian Style

Trindade, Daniela, Rachel Cordeiro, Henrique C. José, David F. Ângelo, Nuno Alves, and Carla Moura. 2021. "Biological Treatments for Temporomandibular Joint Disc Disorders: Strategies in Tissue Engineering" Biomolecules 11, no. 7: 933. https://doi.org/10.3390/biom11070933

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