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Article

The Effect of Mycotoxins and Silymarin on Liver Lipidome of Mice with Non-Alcoholic Fatty Liver Disease

1
Department of Food Chemistry and Analysis, University of Chemistry and Technology, 166 28 Prague, Czech Republic
2
Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine, Charles University, 128 08 Prague, Czech Republic
3
4th Department of Internal Medicine, General University Hospital and 1st Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic
4
Institute of Molecular Genetics of the Czech Academy of Sciences, 142 20 Prague, Czech Republic
5
Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Vladimir N. Uversky
Biomolecules 2021, 11(11), 1723; https://doi.org/10.3390/biom11111723
Received: 27 September 2021 / Revised: 3 November 2021 / Accepted: 16 November 2021 / Published: 19 November 2021
Milk thistle-based dietary supplements have become increasingly popular. The extract from milk thistle (Silybum marianum) is often used for the treatment of liver diseases because of the presence of its active component, silymarin. However, the co-occurrence of toxic mycotoxins in these preparations is quite frequent as well. The objective of this study was to investigate the changes in composition of liver lipidome and other clinical characteristics of experimental mice fed by a high-fat methionine-choline deficient diet inducing non-alcoholic fatty liver disease. The mice were exposed to (i) silymarin, (ii) mycotoxins (trichothecenes, enniatins, beauvericin, and altertoxins) and (iii) both silymarin and mycotoxins, and results were compared to the controls. The liver tissue extracts were analyzed by ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry. Using tools of univariate and multivariate statistical analysis, we were able to identify 48 lipid species from the classes of diacylglycerols, triacylglycerols, free fatty acids, fatty acid esters of hydroxy fatty acids and phospholipids clearly reflecting the dysregulation of lipid metabolism upon exposure to mycotoxin and/or silymarin. View Full-Text
Keywords: mycotoxins; silymarin; lipidome; metabolome; mice liver; mass spectrometry mycotoxins; silymarin; lipidome; metabolome; mice liver; mass spectrometry
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MDPI and ACS Style

Bechynska, K.; Kosek, V.; Fenclova, M.; Muchova, L.; Smid, V.; Suk, J.; Chalupsky, K.; Sticova, E.; Hurkova, K.; Hajslova, J.; Vitek, L.; Stranska, M. The Effect of Mycotoxins and Silymarin on Liver Lipidome of Mice with Non-Alcoholic Fatty Liver Disease. Biomolecules 2021, 11, 1723. https://doi.org/10.3390/biom11111723

AMA Style

Bechynska K, Kosek V, Fenclova M, Muchova L, Smid V, Suk J, Chalupsky K, Sticova E, Hurkova K, Hajslova J, Vitek L, Stranska M. The Effect of Mycotoxins and Silymarin on Liver Lipidome of Mice with Non-Alcoholic Fatty Liver Disease. Biomolecules. 2021; 11(11):1723. https://doi.org/10.3390/biom11111723

Chicago/Turabian Style

Bechynska, Kamila, Vit Kosek, Marie Fenclova, Lucie Muchova, Vaclav Smid, Jakub Suk, Karel Chalupsky, Eva Sticova, Kamila Hurkova, Jana Hajslova, Libor Vitek, and Milena Stranska. 2021. "The Effect of Mycotoxins and Silymarin on Liver Lipidome of Mice with Non-Alcoholic Fatty Liver Disease" Biomolecules 11, no. 11: 1723. https://doi.org/10.3390/biom11111723

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