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Exploring the Intracrine Functions of VEGF-A

Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA 5000, Australia
Author to whom correspondence should be addressed.
Academic Editor: Jody Jonathan Haigh
Biomolecules 2021, 11(1), 128;
Received: 23 December 2020 / Revised: 13 January 2021 / Accepted: 15 January 2021 / Published: 19 January 2021
Vascular endothelial growth factor A (VEGF-A or VEGF) is a highly conserved secreted signalling protein best known for its roles in vascular development and angiogenesis. Many non-endothelial roles for VEGF are now established, with the discovery that VEGF and its receptors VEGFR1 and VEGFR2 are expressed in many non-vascular cell-types, as well as various cancers. In addition to secreted VEGF binding to its receptors in the extracellular space at the cell membrane (i.e., in a paracrine or autocrine mode), intracellularly localised VEGF is emerging as an important signalling molecule regulating cell growth, survival, and metabolism. This intracellular mode of signalling has been termed “intracrine”, and refers to the direct action of a signalling molecule within the cell without being secreted. In this review, we describe examples of intracrine VEGF signalling in regulating cell growth, differentiation and survival, both in normal cell homeostasis and development, as well as in cancer. We further discuss emerging evidence for the molecular mechanisms underpinning VEGF intracrine function, as well as the implications this intracellular mode of VEGF signalling may have for use and design of anti-VEGF cancer therapeutics. View Full-Text
Keywords: VEGF; VEGF-A; intracrine; autocrine; intracellular; signaling; cell survival; apoptosis; cancer; anti-VEGF therapy VEGF; VEGF-A; intracrine; autocrine; intracellular; signaling; cell survival; apoptosis; cancer; anti-VEGF therapy
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MDPI and ACS Style

Wiszniak, S.; Schwarz, Q. Exploring the Intracrine Functions of VEGF-A. Biomolecules 2021, 11, 128.

AMA Style

Wiszniak S, Schwarz Q. Exploring the Intracrine Functions of VEGF-A. Biomolecules. 2021; 11(1):128.

Chicago/Turabian Style

Wiszniak, Sophie, and Quenten Schwarz. 2021. "Exploring the Intracrine Functions of VEGF-A" Biomolecules 11, no. 1: 128.

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