Exploring the Role of Non-Coding RNAs in the Pathophysiology of Systemic Lupus Erythematosus
1
Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran
2
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran
3
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
*
Authors to whom correspondence should be addressed.
Biomolecules 2020, 10(6), 937; https://doi.org/10.3390/biom10060937
Received: 19 May 2020 / Revised: 4 June 2020 / Accepted: 10 June 2020 / Published: 22 June 2020
(This article belongs to the Special Issue The Pathogenic Role of Non Coding RNAs in Autoimmunity)
Systemic lupus erythematosus (SLE) is a chronic immune-related disorder designated by a lack of tolerance to self-antigens and the over-secretion of autoantibodies against several cellular compartments. Although the exact pathophysiology of SLE has not been clarified yet, this disorder has a strong genetic component based on the results of familial aggregation and twin studies. Variation in the expression of non-coding RNAs has been shown to influence both susceptibility to SLE and the clinical course of this disorder. Several long non-coding RNAs (lncRNAs) such as GAS5, MALAT1 and NEAT1 are dysregulated in SLE patients. Moreover, genetic variants within lncRNAs such as SLEAR and linc00513 have been associated with risk of this disorder. The dysregulation of a number of lncRNAs in the peripheral blood of SLE patients has potentiated them as biomarkers for diagnosis, disease activity and therapeutic response. MicroRNAs (miRNAs) have also been shown to affect apoptosis and the function of immune cells. Taken together, there is a compelling rationale for the better understanding of the involvement of these two classes of non-coding RNAs in the pathogenesis of SLE. Clarification of the function of these transcripts has the potential to elucidate the molecular pathophysiology of SLE and provide new opportunities for the development of targeted therapies for this disorder.
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Keywords:
lncRNA; miRNA; systemic lupus erythematosus
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MDPI and ACS Style
Taheri, M.; Eghtedarian, R.; Dinger, M.E.; Ghafouri-Fard, S. Exploring the Role of Non-Coding RNAs in the Pathophysiology of Systemic Lupus Erythematosus. Biomolecules 2020, 10, 937.
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