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Open AccessReview

Trehalose for Ocular Surface Health

by 1,* and 2,3
1
Finnsusp Ltd., Pääskykalliontie 5, FI-21420 Lieto, Finland
2
Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, FI-70210 Kuopio, Finland
3
Department of Ophthalmology, Kuopio University Hospital, FI-70210 Kuopio, Finland
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(5), 809; https://doi.org/10.3390/biom10050809
Received: 3 April 2020 / Revised: 14 May 2020 / Accepted: 21 May 2020 / Published: 25 May 2020
Trehalose is a natural disaccharide synthesized in various life forms, but not found in vertebrates. An increasing body of evidence demonstrates exceptional bioprotective characteristics of trehalose. This review discusses the scientific findings on potential functions of trehalose in oxidative stress, protein clearance, and inflammation, with an emphasis on animal models and clinical trials in ophthalmology. The main objective is to help understand the beneficial effects of trehalose in clinical trials and practice, especially in patients suffering from ocular surface disease. The discussion is supplemented with an overview of patents for the use of trehalose in dry eye and with prospects for the 2020s. View Full-Text
Keywords: trehalose; dry eye syndromes; oxidative stress; autophagy; inflammation; cytoprotection; randomized controlled trials; animal models; molecular chaperones; patents trehalose; dry eye syndromes; oxidative stress; autophagy; inflammation; cytoprotection; randomized controlled trials; animal models; molecular chaperones; patents
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MDPI and ACS Style

Laihia, J.; Kaarniranta, K. Trehalose for Ocular Surface Health. Biomolecules 2020, 10, 809. https://doi.org/10.3390/biom10050809

AMA Style

Laihia J, Kaarniranta K. Trehalose for Ocular Surface Health. Biomolecules. 2020; 10(5):809. https://doi.org/10.3390/biom10050809

Chicago/Turabian Style

Laihia, Jarmo; Kaarniranta, Kai. 2020. "Trehalose for Ocular Surface Health" Biomolecules 10, no. 5: 809. https://doi.org/10.3390/biom10050809

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