No Indices of Increased Type 2 Diabetes Risk in Individuals with Reactive Postprandial Hypoglycemia
Abstract
:1. Introduction
2. Methods
2.1. Definition of Clinical and Laboratory Characteristics
2.2. Statistical Analysis
3. Results
3.1. Characteristics of the Cohort of Individuals with RPH
3.2. Glycemic Response upon Glucose Stimulation in Individuals with RPH at Baseline and Follow-Up
3.3. Presentation of Symptoms in Subjects with RPH
3.4. New-Onset Diabetes Occurrence
3.5. Characteristics of Subjects with the RPH and Control Group
3.6. Comparison of Biochemical Characteristics of Subjects with RPH vs. the Control Group
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Baseline Visit | Follow-Up Visit | ||
---|---|---|---|
Variable Value | p-Value | ||
Body weight (kg) | 67.6 ± 11.3 | 69.3 ± 10.11 | 0.141 |
BMI (kg/m2) | 23.7 (20.4, 26.2) | 24.5 (21.3, 26.8) | 0.215 |
HbA1c (%/ mmol/mol)) | 5.3 (4.9, 5.6) * /34.4 (30.1, 41.0) | 5.0 (4.8, 5.3) * /31.8 (29.0, 34.4) | 0.004 |
Matsuda index | 9.3 (5.3, 12.5) | 9.2 (3.6, 57.4) | 0.620 |
HOMA -IR | 1.07 ± 0.74 | 1.08 ± 1.2 | 0.985 |
Insulinogenic index | 0.84 (0.59, 1.7) | 0.73 (0.43, 1.5) | 0.069 |
Disposition index | 7.4 (5.1, 19.4) | 5.4 (2.0, 29.7) | 0.283 |
RPH Group | Control Group | p-Value | |
---|---|---|---|
Age (years) | 37.2 ± 10.0 | 39.7 ± 9.2 | 0.515 |
Body weight (kg) | 68.6 ± 10.0 | 70.3 ± 11.1 | 0.640 |
Waist circumference (cm) | 84.8 ± 12.0 | 84.2 ± 10.6 | 0.886 |
Hip circumference (cm) | 102.8 ± 8.6 | 104.1 ± 7.9 | 0.755 |
WHR | 0.8 ± 0.1 | 0.8 ± 0.1 | 0.675 |
BMI (kg/m2) | 24.6 ± 3.5 | 24.8 ± 4.3 | 0.877 |
Systolic blood pressure (mmHg) | 107 ± 10 | 108 ± 9 | 0.884 |
Diastolic blood pressure (mmHg) | 70 ± 7 | 72 ± 8 | 0.618 |
Heart rate (beats/min) | 61 ± 10 | 64 ± 11 | 0.423 |
LDL-c (mmol/L) | 2.9 ± 0.61 | 2.66 ± 0.56 | 0.546 |
TG (mmol/L) | 1.1 ± 0.41 | 0.84 ± 0.33 | 0.078 |
HbA1c (%; mmol/mol) | 5.0 ± 0.3 31.1 ± 2.1 | 5.2 ± 0.6 33.3 ± 4.2 | 0.593 |
Matsuda index | 9.2 (3.6, 57.4) | 6.0 (4.0, 76.0) | 0.804 |
HOMA-IR | 1.08 ± 1.2 | 2.5 ± 4.2 | 0.136 |
Insulinogenic index | 0.73 (0.43, 1.5) * | 1.0 (1.0, 3.0) * | 0.028 * |
Disposition index | 5.4 (2.0, 29.7) | 16.0 (7.0, 42.0) | 0.217 |
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Volčanšek, Š.; Rahne Perc, U.; Lunder, M.; Pongrac Barlovič, D. No Indices of Increased Type 2 Diabetes Risk in Individuals with Reactive Postprandial Hypoglycemia. Metabolites 2022, 12, 1232. https://doi.org/10.3390/metabo12121232
Volčanšek Š, Rahne Perc U, Lunder M, Pongrac Barlovič D. No Indices of Increased Type 2 Diabetes Risk in Individuals with Reactive Postprandial Hypoglycemia. Metabolites. 2022; 12(12):1232. https://doi.org/10.3390/metabo12121232
Chicago/Turabian StyleVolčanšek, Špela, Urška Rahne Perc, Mojca Lunder, and Draženka Pongrac Barlovič. 2022. "No Indices of Increased Type 2 Diabetes Risk in Individuals with Reactive Postprandial Hypoglycemia" Metabolites 12, no. 12: 1232. https://doi.org/10.3390/metabo12121232