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Article

Emerging Approach for the Application of Hibiscus sabdariffa Extract Ointment in the Superficial Burn Care

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Department of Biochemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa 11152, Egypt
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Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Al Sharqia 44519, Egypt
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Pathology Department, Faculty of Veterinary Medicine, Kafr Elsheikh University, Kafr Elsheikh 33516, Egypt
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Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa 11152, Egypt
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Biochemistry and Nutrition Department, Faculty of Women for Arts, Sciences and Education, Ain Shams University, Heliopolis, Cairo 6360141, Egypt
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Department of Clinical Pharmacology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt
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Faculty of Medicine and Pharmacy, University of Oradea, P-ta 1 Decembrie 10, 410087 Oradea, Romania
*
Author to whom correspondence should be addressed.
Academic Editor: Thierry Besson
Sci. Pharm. 2022, 90(3), 41; https://doi.org/10.3390/scipharm90030041
Received: 3 May 2022 / Revised: 13 June 2022 / Accepted: 18 June 2022 / Published: 30 June 2022
(This article belongs to the Special Issue Feature Papers in Scientia Pharmaceutica)
Wound healing comprises organized events involving tissue repair and regeneration. The discovery of toll-like receptors (TLRs) sheds recent light on the mechanisms involved in initiating inflammatory responses throughout the healing cascades. Hibiscus sabdariffa (HS) components may exhibit a wound healing action, owing to their antioxidant and anti-inflammatory activities. This study was designed to investigate the early effects of HS loaded in an ointment base on wound healing, antioxidant, antimicrobial effects, burning intensity, and histopathological features on the rat burn model in comparison to the standard treatment, Iruxol® ointment. A burn injury model was used to evaluate the wound healing potency of the preparation. Rats were treated with ointments three times on the day of the induction of the burn. Findings revealed that the strong antioxidant properties of the HS-loaded ointment augmented the skin healing potential by stimulating biomarkers required for skin regeneration. HS repressed the burning-induced inflammation by the effective reduction in the levels of tumor necrosis factor α (TNF-α) and IL-6 through TLR4 protein inhibition. Topical HS downregulates transforming growth factor-beta (TGF-β) levels. HS extract possesses a potential bactericidal activity against highly resistant clinical isolates of Pseudomonas aeruginosa. Overall, this study proclaims that HS-loaded topical preparations could be a valuable product that serves as adjuvants to accelerate burn wound healing through inactivating the TLR4 pathway. View Full-Text
Keywords: Hibiscus sabdariffa; TGF-β; TNF-α; TLRs; wound healing; Pseudomonas aeruginosa Hibiscus sabdariffa; TGF-β; TNF-α; TLRs; wound healing; Pseudomonas aeruginosa
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MDPI and ACS Style

Khalil, R.; Yahya, G.; Abdo, W.S.; El-Tanbouly, G.S.; Johar, D.; Abdel-Halim, M.S.; Eissa, H.; Magheru, C.; Saber, S.; Cavalu, S. Emerging Approach for the Application of Hibiscus sabdariffa Extract Ointment in the Superficial Burn Care. Sci. Pharm. 2022, 90, 41. https://doi.org/10.3390/scipharm90030041

AMA Style

Khalil R, Yahya G, Abdo WS, El-Tanbouly GS, Johar D, Abdel-Halim MS, Eissa H, Magheru C, Saber S, Cavalu S. Emerging Approach for the Application of Hibiscus sabdariffa Extract Ointment in the Superficial Burn Care. Scientia Pharmaceutica. 2022; 90(3):41. https://doi.org/10.3390/scipharm90030041

Chicago/Turabian Style

Khalil, Rania, Galal Yahya, Walied S. Abdo, Ghada S. El-Tanbouly, Dina Johar, Mahmoud Saad Abdel-Halim, Hanan Eissa, Calin Magheru, Sameh Saber, and Simona Cavalu. 2022. "Emerging Approach for the Application of Hibiscus sabdariffa Extract Ointment in the Superficial Burn Care" Scientia Pharmaceutica 90, no. 3: 41. https://doi.org/10.3390/scipharm90030041

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