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Open AccessArticle

Effect on Body Weight and Adipose Tissue by Cariprazine: A Head-to-Head Comparison Study to Olanzapine and Aripiprazole in Rats

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Department of Pharmacology and Clinical Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania
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Department of Anatomy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania
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Department of Pharmacology and Pharmacotherapy, Semmelweis University, 1085 Budapest, Hungary
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Department of Pharmaceutical Biochemistry and the Chemistry of Environmental Factors, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania
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Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania
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Doctoral School, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania
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Author to whom correspondence should be addressed.
Sci. Pharm. 2020, 88(4), 50; https://doi.org/10.3390/scipharm88040050
Received: 30 August 2020 / Revised: 24 September 2020 / Accepted: 29 September 2020 / Published: 28 October 2020
Cariprazine (Car) is a recently approved second generation antipsychotic (SGA) with unique pharmacodynamic profile, being a partial agonist at both dopamine D2/3 receptor subtypes, with almost 10 times greater affinity towards D3. SGAs are known to increase body weight, alter serum lipids, and stimulate adipogenesis but so far, limited information about the adverse effects is available with this drug. In order to study this new SGA with such a unique mechanism of action, we compared Car to substances that are considered references and are well characterized: olanzapine (Ola) and aripiprazole (Ari). We studied the effects on body weight and also assessed the adipogenesis in rats. The drugs were self-administered in two different doses to female, adult, Wistar rats for six weeks. Weekly body weight change, vacuole size of adipocytes, Sterol Regulatory Element Binding Protein-1 (SREBP-1) and Uncoupling Protein-1 (UCP-1) expression were measured from the visceral adipose tissue (AT). The adipocyte’s vacuole size, and UCP-1 expression were increased while body weight gain was diminished by Car. by increasing UCP-1 might stimulate the thermogenesis, that could potentially explain the weight gain lowering effect through enhanced lipolysis. View Full-Text
Keywords: second generation antipsychotic; metabolic syndrome; cariprazine; aripiprazole; olanzapine; adipose tissue second generation antipsychotic; metabolic syndrome; cariprazine; aripiprazole; olanzapine; adipose tissue
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Bába, L.-I.; Gáll, Z.; Kolcsár, M.; Pap, Z.; Varga, Z.V.; Kovács, B.; Hack, B.; Kun, I.-Z. Effect on Body Weight and Adipose Tissue by Cariprazine: A Head-to-Head Comparison Study to Olanzapine and Aripiprazole in Rats. Sci. Pharm. 2020, 88, 50.

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