A New DNA Repair-Related Platform for Pharmaceutical Outlook in Cancer Therapies: Ultrashort Single-Stranded Polynucleotides
Abstract
:1. Introduction
2. Materials and Methods
2.1. Reagents and Disposal Materials
2.2. Ligands
2.3. Enzymes
2.4. Enzyme Activity Estimation
2.5. DNA and Protein Measurements
2.6. Radioactivity Measurements
2.7. Ligand–Enzyme Binding Measurements
2.8. Statistics
3. Results
4. Discussion
5. Conclusions
Author Contributions
Acknowledgments
Conflicts of Interest
Abbreviations
ssDNA | single-stranded DNA |
DNApolβ | DNA polymerase beta |
PDRN | polydeoxyribonucleotides |
MIE | magnetic isotope effects |
AML | acute mueloid leukemia |
RB | retinoblastoma |
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Stovbun, S.; Ermakov, K.; Bukhvostov, A.; Vedenkin, A.; Kuznetsov, D. A New DNA Repair-Related Platform for Pharmaceutical Outlook in Cancer Therapies: Ultrashort Single-Stranded Polynucleotides. Sci. Pharm. 2019, 87, 25. https://doi.org/10.3390/scipharm87040025
Stovbun S, Ermakov K, Bukhvostov A, Vedenkin A, Kuznetsov D. A New DNA Repair-Related Platform for Pharmaceutical Outlook in Cancer Therapies: Ultrashort Single-Stranded Polynucleotides. Scientia Pharmaceutica. 2019; 87(4):25. https://doi.org/10.3390/scipharm87040025
Chicago/Turabian StyleStovbun, Sergey, Kirill Ermakov, Alexander Bukhvostov, Alexander Vedenkin, and Dmitry Kuznetsov. 2019. "A New DNA Repair-Related Platform for Pharmaceutical Outlook in Cancer Therapies: Ultrashort Single-Stranded Polynucleotides" Scientia Pharmaceutica 87, no. 4: 25. https://doi.org/10.3390/scipharm87040025