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Article

Potential Role of Microfibrillar-Associated Protein 4, Fibrotic Indices and Oxidative Stress in Hepatocellular Carcinoma

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Department of Biochemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa 35712, Egypt
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Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
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Department of Clinical Pathology, Students’ Hospital, Mansoura University, Mansoura 35516, Egypt
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Department of Internal Medicine, Medical Oncology Unit, Oncology Center, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt
*
Authors to whom correspondence should be addressed.
Sci. Pharm. 2018, 86(4), 44; https://doi.org/10.3390/scipharm86040044
Received: 31 August 2018 / Revised: 26 September 2018 / Accepted: 27 September 2018 / Published: 30 September 2018
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality worldwide. In an attempt to understand some potential mechanisms of persistence and oncogenicity of Hepatitis C virus (HCV)-related HCC, microfibrillar-associated protein 4 (MFAP4), fibrotic indices and oxidative status biomarkers were assessed in the sera of 50 patients with HCV-associated HCC, 25 patients with HCV-related liver cirrhosis and 15 healthy individuals. Serum oxidized Coenzyme Q10 (CoQ10) and malondialdehyde showed significant elevation in HCC patients compared to the control group (p < 0.001), as well as cirrhotic patients (p < 0.05 and p < 0.001, respectively), while serum glutathione content and superoxide dismutase activity were significantly decreased in HCC patients compared to the control group (p < 0.001). Serum MFAP4, aspartate aminotransferase to platelet ratio index (APRI), fibrosis index based on the 4 factors (FIB-4) and Forns index showed significant increase in HCC patients compared to the control group (p < 0.001), while only APRI and FIB-4 were significantly different between HCC and cirrhotic patients (p < 0.05), with a sensitivity of 86% and 92%, respectively, at cut off ≥0.7 for APRI and ≥1.57 for FIB-4. Therefore, increasing oxidative stress and fibrosis might mediate HCV induced cirrhosis and HCC. APRI and FIB-4 may be used as a simple non-expensive formula for the screening of HCC rather than MFAP4. View Full-Text
Keywords: HCC; MFAP4; fibrotic indices; oxidized Coenzyme Q10; oxidative status HCC; MFAP4; fibrotic indices; oxidized Coenzyme Q10; oxidative status
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MDPI and ACS Style

Salama, M.M.; Nomir, M.M.; Fahmi, M.W.; El-Gayar, A.M.; El-Shishtawy, M.M. Potential Role of Microfibrillar-Associated Protein 4, Fibrotic Indices and Oxidative Stress in Hepatocellular Carcinoma. Sci. Pharm. 2018, 86, 44. https://doi.org/10.3390/scipharm86040044

AMA Style

Salama MM, Nomir MM, Fahmi MW, El-Gayar AM, El-Shishtawy MM. Potential Role of Microfibrillar-Associated Protein 4, Fibrotic Indices and Oxidative Stress in Hepatocellular Carcinoma. Scientia Pharmaceutica. 2018; 86(4):44. https://doi.org/10.3390/scipharm86040044

Chicago/Turabian Style

Salama, Mohamed M., Manal M. Nomir, Maryan W. Fahmi, Amal M. El-Gayar, and Mamdouh M. El-Shishtawy 2018. "Potential Role of Microfibrillar-Associated Protein 4, Fibrotic Indices and Oxidative Stress in Hepatocellular Carcinoma" Scientia Pharmaceutica 86, no. 4: 44. https://doi.org/10.3390/scipharm86040044

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