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Volume 84
Issue 2
10.3797/scipharm.1505-15
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Enhanced Permeation of Antiemetic Drug from Buccoadhesive Tablets by Using Bile Salts as Permeation Enhancers: Formulation characterization, In Vitro and Ex Vivo Studies

by
C. P. JAIN
*,
Garima JOSHI
*,
Udichi KATARIA
and
Komal PATEL
Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Main University Campus, Udaipur, Rajasthan, 313001, India
*
Authors to whom correspondence should be addressed.
Sci. Pharm. 2016, 84(2), 379-392; https://doi.org/10.3797/scipharm.1505-15
Submission received: 19 May 2015 / Accepted: 29 July 2015 / Published: 29 July 2015
Versions Notes

Abstract

Buccal bioadhesive bilayer tablets of prochlorperazine maleate were designed and formulated by using buccoadhesive polymers such as hydroxypropylmethyl cellulose, Carbopol 934P, and sodium alginate. Physicochemical characteristics like the uniformity of weight, hardness, thickness, surface pH, drug content, swelling index, microenvironment pH, in vitro drug release, and in vivo buccoadhesion time of the prepared tablets were found to be dependent on the type and composition of the buccoadhesive materials used. The effect of bile salts on the permeation was studied through porcine buccal mucosa and it was found that out of three bile salts incorporated (sodium glycholate, sodium taurocholate, and sodium deoxycholate), sodium glycholate enhanced the permeation rate of prochlorperazine maleate by an enhancement factor of 1.37.
Keywords: Buccal tablet; Ex vivo; Antiemetic; Prochlorperazine; Bile salts Buccal tablet; Ex vivo; Antiemetic; Prochlorperazine; Bile salts

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MDPI and ACS Style

JAIN, C.P.; JOSHI, G.; KATARIA, U.; PATEL, K. Enhanced Permeation of Antiemetic Drug from Buccoadhesive Tablets by Using Bile Salts as Permeation Enhancers: Formulation characterization, In Vitro and Ex Vivo Studies. Sci. Pharm. 2016, 84, 379-392. https://doi.org/10.3797/scipharm.1505-15

AMA Style

JAIN CP, JOSHI G, KATARIA U, PATEL K. Enhanced Permeation of Antiemetic Drug from Buccoadhesive Tablets by Using Bile Salts as Permeation Enhancers: Formulation characterization, In Vitro and Ex Vivo Studies. Scientia Pharmaceutica. 2016; 84(2):379-392. https://doi.org/10.3797/scipharm.1505-15

Chicago/Turabian Style

JAIN, C. P., Garima JOSHI, Udichi KATARIA, and Komal PATEL. 2016. "Enhanced Permeation of Antiemetic Drug from Buccoadhesive Tablets by Using Bile Salts as Permeation Enhancers: Formulation characterization, In Vitro and Ex Vivo Studies" Scientia Pharmaceutica 84, no. 2: 379-392. https://doi.org/10.3797/scipharm.1505-15

APA Style

JAIN, C. P., JOSHI, G., KATARIA, U., & PATEL, K. (2016). Enhanced Permeation of Antiemetic Drug from Buccoadhesive Tablets by Using Bile Salts as Permeation Enhancers: Formulation characterization, In Vitro and Ex Vivo Studies. Scientia Pharmaceutica, 84(2), 379-392. https://doi.org/10.3797/scipharm.1505-15

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