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Volume 84
Issue 1
10.3797/scipharm.ISP.2015.11
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

In Silico Study to Develop a Lectin-Like Protein from Mushroom Agaricus bisporus for Pharmaceutical Application

by
Wangsa Tirta ISMAYA
1,*,
YUNITA
2,
Sophi DAMAYANTI
3,
Caroline WIJAYA
1,
Raymond R. TJANDRAWINATA
1,
Debbie Sofie RETNONINGRUM
4 and
Heni RACHMAWATI
2
1
Dexa Laboratories of Biomolecular Sciences, Industri Selatan V, Blok PP No. 7, Kawasan Industri, Jababeka II, Cikarang 17550, Indonesia.
2
Research group of Pharmaceutics, School of Pharmacy, Institut Teknologi Bandung, Jl. Ganesa 10, Bandung 40132, Indonesia.
3
Research group of Pharmacochemistry, School of Pharmacy, Institut Teknologi Bandung, Jl. Ganesa 10, Bandung 40132, Indonesia.
4
Research group of Biotechnology, School of Pharmacy, Institut Teknologi Bandung, Jl. Ganesa 10, Bandung 40132, Indonesia.
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2016, 84(1), 203-217; https://doi.org/10.3797/scipharm.ISP.2015.11
Submission received: 5 September 2015 / Accepted: 15 December 2015 / Published: 14 February 2016
Versions Notes

Abstract

A lectin-like protein of unknown function designated as LSMT was recently discovered in the edible mushroom Agaricus bisporus. The protein shares high structural similarity to HA-33 from Clostridium botulinum (HA33) and Ricin-B-like lectin from the mushroom Clitocybe nebularis (CNL), which have been developed as drug carrier and anti-cancer, respectively. These homologous proteins display the ability to penetrate the intestinal epithelial cell monolayer, and are beneficial for oral administration. As the characteristics of LSMT are unknown, a structural study in silico was performed to assess its potential pharmaceutical application. The study suggested potential binding to target ligands such as HA-33 and CNL although the nature, specificity, capacity, mode, and strength may differ. Further molecular docking experiments suggest that interactions between the LSMT and tested ligands may take place. This finding indicates the possible use of the LSMT protein, initiating new research on its use for pharmaceutical purposes.
Keywords: In silico protein study; Lectin-like protein; Light subunit mushroom tyrosinase; Molecular docking; Novel pharmaceutical protein; Oral delivery In silico protein study; Lectin-like protein; Light subunit mushroom tyrosinase; Molecular docking; Novel pharmaceutical protein; Oral delivery

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MDPI and ACS Style

ISMAYA, W.T.; YUNITA; DAMAYANTI, S.; WIJAYA, C.; TJANDRAWINATA, R.R.; RETNONINGRUM, D.S.; RACHMAWATI, H. In Silico Study to Develop a Lectin-Like Protein from Mushroom Agaricus bisporus for Pharmaceutical Application. Sci. Pharm. 2016, 84, 203-217. https://doi.org/10.3797/scipharm.ISP.2015.11

AMA Style

ISMAYA WT, YUNITA, DAMAYANTI S, WIJAYA C, TJANDRAWINATA RR, RETNONINGRUM DS, RACHMAWATI H. In Silico Study to Develop a Lectin-Like Protein from Mushroom Agaricus bisporus for Pharmaceutical Application. Scientia Pharmaceutica. 2016; 84(1):203-217. https://doi.org/10.3797/scipharm.ISP.2015.11

Chicago/Turabian Style

ISMAYA, Wangsa Tirta, YUNITA, Sophi DAMAYANTI, Caroline WIJAYA, Raymond R. TJANDRAWINATA, Debbie Sofie RETNONINGRUM, and Heni RACHMAWATI. 2016. "In Silico Study to Develop a Lectin-Like Protein from Mushroom Agaricus bisporus for Pharmaceutical Application" Scientia Pharmaceutica 84, no. 1: 203-217. https://doi.org/10.3797/scipharm.ISP.2015.11

APA Style

ISMAYA, W. T., YUNITA, DAMAYANTI, S., WIJAYA, C., TJANDRAWINATA, R. R., RETNONINGRUM, D. S., & RACHMAWATI, H. (2016). In Silico Study to Develop a Lectin-Like Protein from Mushroom Agaricus bisporus for Pharmaceutical Application. Scientia Pharmaceutica, 84(1), 203-217. https://doi.org/10.3797/scipharm.ISP.2015.11

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