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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Open AccessArticle
Sci. Pharm. 2015, 83(4), 671-682; (registering DOI)

Formulation and Evaluation of Controlled Release Floating Microballoons of Stavudine

Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciencies, Chandramoulipuram, Chowdavaram, Guntur-522019, India
Author to whom correspondence should be addressed.
Received: 14 January 2015 / Accepted: 9 June 2015 / Published: 9 June 2015
PDF [499 KB, uploaded 8 September 2016]


The aim of this study was to formulate and evaluate stavudine floating microballoons for controlled drug release. Initially, the drug-loaded low-density granular pellets were prepared with hydroxypropyl methylcellulose E5 grade and by using isopropyl alcohol as a granulating fluid. Further, the low-density granular pellets were subjected to microencapsulation by an emulsion evaporation technique using ethyl cellulose 7 cps and Eudragit S 100 as coating polymers and 1% w/v polyethylene glycol 400 as aqueous phase. The prepared microballoons were characterized for their particle size analysis, angle of repose, and compressibility index. The in vitro release studies were performed in 0.1 N HCl as medium. The prepared microballoons were free-flowing and spherical in shape. From all the formulations, F5E and F5F can be considered as promising controlled release floating microballoons of stavudine providing first-order release over a period of 12 hours, with a minimum floating lag time of 1 minute. It was found that the ratio of the drug & polymer, stirring speed, and concentration of surfactant were the most significant variables which influenced the size of the stavudine microballoons under the applied experimental conditions.
Keywords: Stavudine; Floating Microballoons; HPMC E5; Controlled Release; Eudragit RS 100 Stavudine; Floating Microballoons; HPMC E5; Controlled Release; Eudragit RS 100
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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VIDYADHARA, S.; SASIDHAR, R.L.; BALAKRISHNA, T.; BALAJI, B.; AMRUTHA, R. Formulation and Evaluation of Controlled Release Floating Microballoons of Stavudine. Sci. Pharm. 2015, 83, 671-682.

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