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Sci. Pharm.
Volume 83
Issue 4
10.3797/scipharm.1501-07
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Formulation and Evaluation of Controlled Release Floating Microballoons of Stavudine

by
Suryadevara VIDYADHARA
*,
Reddyvalam Lankapalli SASIDHAR
,
Talamanchi BALAKRISHNA
,
Boyapati BALAJI
and
Ravi AMRUTHA
Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciencies, Chandramoulipuram, Chowdavaram, Guntur-522019, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2015, 83(4), 671-682; https://doi.org/10.3797/scipharm.1501-07
Submission received: 14 January 2015 / Accepted: 9 June 2015 / Published: 9 June 2015
Versions Notes

Abstract

The aim of this study was to formulate and evaluate stavudine floating microballoons for controlled drug release. Initially, the drug-loaded low-density granular pellets were prepared with hydroxypropyl methylcellulose E5 grade and by using isopropyl alcohol as a granulating fluid. Further, the low-density granular pellets were subjected to microencapsulation by an emulsion evaporation technique using ethyl cellulose 7 cps and Eudragit S 100 as coating polymers and 1% w/v polyethylene glycol 400 as aqueous phase. The prepared microballoons were characterized for their particle size analysis, angle of repose, and compressibility index. The in vitro release studies were performed in 0.1 N HCl as medium. The prepared microballoons were free-flowing and spherical in shape. From all the formulations, F5E and F5F can be considered as promising controlled release floating microballoons of stavudine providing first-order release over a period of 12 hours, with a minimum floating lag time of 1 minute. It was found that the ratio of the drug & polymer, stirring speed, and concentration of surfactant were the most significant variables which influenced the size of the stavudine microballoons under the applied experimental conditions.
Keywords: Stavudine; Floating Microballoons; HPMC E5; Controlled Release; Eudragit RS 100 Stavudine; Floating Microballoons; HPMC E5; Controlled Release; Eudragit RS 100

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MDPI and ACS Style

VIDYADHARA, S.; SASIDHAR, R.L.; BALAKRISHNA, T.; BALAJI, B.; AMRUTHA, R. Formulation and Evaluation of Controlled Release Floating Microballoons of Stavudine. Sci. Pharm. 2015, 83, 671-682. https://doi.org/10.3797/scipharm.1501-07

AMA Style

VIDYADHARA S, SASIDHAR RL, BALAKRISHNA T, BALAJI B, AMRUTHA R. Formulation and Evaluation of Controlled Release Floating Microballoons of Stavudine. Scientia Pharmaceutica. 2015; 83(4):671-682. https://doi.org/10.3797/scipharm.1501-07

Chicago/Turabian Style

VIDYADHARA, Suryadevara, Reddyvalam Lankapalli SASIDHAR, Talamanchi BALAKRISHNA, Boyapati BALAJI, and Ravi AMRUTHA. 2015. "Formulation and Evaluation of Controlled Release Floating Microballoons of Stavudine" Scientia Pharmaceutica 83, no. 4: 671-682. https://doi.org/10.3797/scipharm.1501-07

APA Style

VIDYADHARA, S., SASIDHAR, R. L., BALAKRISHNA, T., BALAJI, B., & AMRUTHA, R. (2015). Formulation and Evaluation of Controlled Release Floating Microballoons of Stavudine. Scientia Pharmaceutica, 83(4), 671-682. https://doi.org/10.3797/scipharm.1501-07

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