Next Article in Journal
Molecular Modeling on Structure-Function Analysis of Human Progesterone Receptor Modulators
Previous Article in Journal
Design, Synthesis and Biological Evaluation of New 5,5-Diarylhydantoin Derivatives as Selective Cyclooxygenase-2 Inhibitors
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Sci. Pharm.
Volume 81
Issue 2
10.3797/scipharm.1301-13
scipharm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Synthesis and Biological Activity of New Thiopyrano[2,3-d]thiazoles Containing a Naphthoquinone Moiety

by
Dmytro ATAMANYUK
1,2,
Borys ZIMENKOVSKY
1,
Vasyl ATAMANYUK
1,
Ihor NEKTEGAYEV
1 and
Roman LESYK
1,*
1
Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, Ukraine
2
Present address: Mutabilis, 102 Avenue Gaston Roussel, 93230 Romainville, France
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2013, 81(2), 423-436; https://doi.org/10.3797/scipharm.1301-13
Submission received: 14 January 2013 / Accepted: 4 February 2013 / Published: 4 February 2013
Versions Notes

Abstract

Novel 11-substituted 3,11-dihydro-2H-benzo[6,7]thiochromeno[2,3-d][1,3]-thiazole-2,5,10-triones 4a–i were synthesized in 75–90% yields via the hetero-Diels-Alder reaction of 5-arylidene-4-thioxo-2-thiazolidinones with 1,4-naphtho-quinone. The synthesized compounds were evaluated for their antineoplastic and antimycobacterial activities. A moderate selectivity against melanoma cancer cells (GI50 (UACC-257-melanoma) = 0.22 μM) was demonstrated for 4i, whereas derivatives 4a, 4c, 4g, and 4h showed promising antimycobacterial activity at a low toxicity level.
Keywords: hetero-Diels-Alder reaction; 4-Thioxo-2-thiazolidinones; Thiopyrano[2,3-d]thiazoles; Anticancer activity; Antimycobacterial activity; Melanoma hetero-Diels-Alder reaction; 4-Thioxo-2-thiazolidinones; Thiopyrano[2,3-d]thiazoles; Anticancer activity; Antimycobacterial activity; Melanoma

Share and Cite

MDPI and ACS Style

ATAMANYUK, D.; ZIMENKOVSKY, B.; ATAMANYUK, V.; NEKTEGAYEV, I.; LESYK, R. Synthesis and Biological Activity of New Thiopyrano[2,3-d]thiazoles Containing a Naphthoquinone Moiety. Sci. Pharm. 2013, 81, 423-436. https://doi.org/10.3797/scipharm.1301-13

AMA Style

ATAMANYUK D, ZIMENKOVSKY B, ATAMANYUK V, NEKTEGAYEV I, LESYK R. Synthesis and Biological Activity of New Thiopyrano[2,3-d]thiazoles Containing a Naphthoquinone Moiety. Scientia Pharmaceutica. 2013; 81(2):423-436. https://doi.org/10.3797/scipharm.1301-13

Chicago/Turabian Style

ATAMANYUK, Dmytro, Borys ZIMENKOVSKY, Vasyl ATAMANYUK, Ihor NEKTEGAYEV, and Roman LESYK. 2013. "Synthesis and Biological Activity of New Thiopyrano[2,3-d]thiazoles Containing a Naphthoquinone Moiety" Scientia Pharmaceutica 81, no. 2: 423-436. https://doi.org/10.3797/scipharm.1301-13

APA Style

ATAMANYUK, D., ZIMENKOVSKY, B., ATAMANYUK, V., NEKTEGAYEV, I., & LESYK, R. (2013). Synthesis and Biological Activity of New Thiopyrano[2,3-d]thiazoles Containing a Naphthoquinone Moiety. Scientia Pharmaceutica, 81(2), 423-436. https://doi.org/10.3797/scipharm.1301-13

Article Metrics

Back to TopTop