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Volume 81
Issue 2
10.3797/scipharm.1303-03
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

7-Aza-des-A-steroids with Antimicrobial and Cytotoxic Activity

by
Melanie KROJER
,
Marco KELLER
and
Franz BRACHER
*
Department of Pharmacy – Center for Drug Research, Ludwig-Maximilians University, Butenandtstr. 5–13, 81377 Munich, Germany
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2013, 81(2), 329-338; https://doi.org/10.3797/scipharm.1303-03
Submission received: 2 March 2013 / Accepted: 14 April 2013 / Published: 14 April 2013
Versions Notes

Abstract

This paper describes a convenient approach to the 7-aza-des-A-steroid (6,6a,7,8,9,9a-hexahydro-5H-cyclopenta[h]quinoline) scaffold starting from Grundmann's ketone using two different pyridine annulation protocols. The biological evaluation of the pyridine and pyridinium products revealed that these compounds unexpectedly do not interfere with ergosterol and cholesterol biosynthesis. The pyridinium compound 6 showed significant antimicrobial and cytotoxic activities which are most likely due to its detergent-like structure.
Keywords: Azasteroids; Pyridine; Annulation; Antimicrobial activity; Cytotoxic activity Azasteroids; Pyridine; Annulation; Antimicrobial activity; Cytotoxic activity

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MDPI and ACS Style

KROJER, M.; KELLER, M.; BRACHER, F. 7-Aza-des-A-steroids with Antimicrobial and Cytotoxic Activity. Sci. Pharm. 2013, 81, 329-338. https://doi.org/10.3797/scipharm.1303-03

AMA Style

KROJER M, KELLER M, BRACHER F. 7-Aza-des-A-steroids with Antimicrobial and Cytotoxic Activity. Scientia Pharmaceutica. 2013; 81(2):329-338. https://doi.org/10.3797/scipharm.1303-03

Chicago/Turabian Style

KROJER, Melanie, Marco KELLER, and Franz BRACHER. 2013. "7-Aza-des-A-steroids with Antimicrobial and Cytotoxic Activity" Scientia Pharmaceutica 81, no. 2: 329-338. https://doi.org/10.3797/scipharm.1303-03

APA Style

KROJER, M., KELLER, M., & BRACHER, F. (2013). 7-Aza-des-A-steroids with Antimicrobial and Cytotoxic Activity. Scientia Pharmaceutica, 81(2), 329-338. https://doi.org/10.3797/scipharm.1303-03

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