The Use of Small and Wide Angle X-Ray Scattering (SWAXS) for the Physico-Chemical Characterization of Solid Dispersions

M. METZLER; A. HODZIC; P. LAGGNER; N. A. URBANETZ

doi:10.3797/scipharm.cespt.8.PPAT02

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Published: 12 July 2010

The Use of Small and Wide Angle X-Ray Scattering (SWAXS) for the Physico-Chemical Characterization of Solid Dispersions

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Research Center Pharmaceutical Engineering GmbH, Graz, Austria

Institut of Biophysics and X-Ray Structure Research, Austrian Academy of Sciences, Graz, Austria

HECUS X-Ray Systems, Graz, Austria

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Institute for Process and Particle Engineering, Graz University of technology, Graz, Austria

Sci. Pharm.2010, 78(3), 691;https://doi.org/10.3797/scipharm.cespt.8.PPAT02

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Abstract

Solid dispersions of active pharmaceutical ingredients (APIs) in freely water soluble carriers are often used in order to improve dissolution rate and/or solubility of poorly water soluble drugs [1] in the aqueous gastro intestinal fluids. [...]

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