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Sci. Pharm.
Volume 78
Issue 2
10.3797/scipharm.1001-04
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Formulation Optimization of Hydrodynamically Balanced Oral Controlled Release Bioadhesive Tablets of Tramadol Hydrochloride

by
Bhupinder SINGH
*,
Ashu RANI
,
BABITA
,
Naveen AHUJA
and
Rishi KAPIL
University Institute of Pharmaceutical Sciences, UGC Center of Advanced Studies, Panjab University 160 014, Chandigarh, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2010, 78(2), 303-324; https://doi.org/10.3797/scipharm.1001-04
Submission received: 6 January 2010 / Accepted: 12 April 2010 / Published: 18 April 2010
Versions Notes

Abstract

The directly compressible floating-bioadhesive tablets of tramadol were formulated using varying amounts Carbopol 971P (CP) and hydroxypropylmethyl cellulose (HPMC), along with other requisite excipients. In vitro drug release profile, floatational characteristics and ex vivo bioadhesive strength using texture analyzer were determined, and systematically optimized using a 32 central composite design (CCD). The studies indicated successful formulation of gastroretentive compressed matrices with excellent controlled release, mucoadhesion and hydrodynamic balance. Comparison of the dissolution profiles of the optimized formulation, with optimal composition of CP:HPMC :: 80.0:125.0, with that of the marketed controlled release formulation other indicated analogy of drug release performance with each other. Validation of optimization study using eight confirmatory experimental runs indicated very high degree of prognostic ability of CCD with mean ± SEM of −0.06% ± 0.37. Further, the study successfully unravels the effect of the polymers on the selected response variables.
Keywords: Drug delivery; Gastroretentive; Mucoadhesive; Experimental design; Floatation Drug delivery; Gastroretentive; Mucoadhesive; Experimental design; Floatation

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MDPI and ACS Style

SINGH, B.; RANI, A.; BABITA; AHUJA, N.; KAPIL, R. Formulation Optimization of Hydrodynamically Balanced Oral Controlled Release Bioadhesive Tablets of Tramadol Hydrochloride. Sci. Pharm. 2010, 78, 303-324. https://doi.org/10.3797/scipharm.1001-04

AMA Style

SINGH B, RANI A, BABITA, AHUJA N, KAPIL R. Formulation Optimization of Hydrodynamically Balanced Oral Controlled Release Bioadhesive Tablets of Tramadol Hydrochloride. Scientia Pharmaceutica. 2010; 78(2):303-324. https://doi.org/10.3797/scipharm.1001-04

Chicago/Turabian Style

SINGH, Bhupinder, Ashu RANI, BABITA, Naveen AHUJA, and Rishi KAPIL. 2010. "Formulation Optimization of Hydrodynamically Balanced Oral Controlled Release Bioadhesive Tablets of Tramadol Hydrochloride" Scientia Pharmaceutica 78, no. 2: 303-324. https://doi.org/10.3797/scipharm.1001-04

APA Style

SINGH, B., RANI, A., BABITA, AHUJA, N., & KAPIL, R. (2010). Formulation Optimization of Hydrodynamically Balanced Oral Controlled Release Bioadhesive Tablets of Tramadol Hydrochloride. Scientia Pharmaceutica, 78(2), 303-324. https://doi.org/10.3797/scipharm.1001-04

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