Synthesis of Deuterated Analogs of Honokiol

A. HÜFNER; W. SCHÜHLY

doi:10.3797/scipharm.oephg.21.PO-25

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Abstract

16 April 2009

Synthesis of Deuterated Analogs of Honokiol

and

Institute of Pharm. Sciences, Dept. of Pharm. Chemistry, University of Graz, Universitätsplatz 1, 8010 Graz, Austria

Institute of Pharm. Sciences, Dept. of Pharmacognosy, University of Graz, Universitätsplatz 4, 8010 Graz, Austria

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Sci. Pharm.2009, 77(7), 224;https://doi.org/10.3797/scipharm.oephg.21.PO-25

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Abstract

The genus Magnolia plays a role in American as well as in Asian medicinal systems such as TCM or Japanese Kampo medicine [1, 2]. Main lignan constituents in the seeds of the north american Magnolia grandiflora are honokiol (1) and 4'-O-methyl-honokiol. They are known to possess anti-inflammatory activities with COX-2 inhibitory activity (IC50) of about 0.1 to 3 μM.

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