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Volume 76
Issue 4
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Article

Synthesis and Preclinical Studies of [61Cu]-N-(2-hydroxyacetophenone)glycinate as a Possible PET Radiopharmaceutical

by
Amir R. JALILIAN
1,*,
Hamid SADEGHI
2,
Hassan ZANDI
3,
Pejman ROWSHANFARZAD
1,
Kamaledin SHAFAII
1,
Mohsen KAMALI-DEHGHAN
1,
Javad GAROUSI
1,
Abbas MAJDABADI
1 and
Mohammad B. TAVAKOLI
2
1
Nuclear Medicine Research Group, Agricultural, Medical and Industrial Research School (AMIRS), Karaj, P.O.Box: 31485-498, Iran
2
Department of Biomedical Physics and Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3
Islamic Azad University, Science and Research Unit, P.O.Box: 14155-775, Tehran, Iran
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2008, 76(4), 637-652; https://doi.org/10.3797/scipharm.0808-13
Submission received: 19 August 2008 / Accepted: 14 September 2008 / Published: 17 September 2008
Versions Notes

Abstract

[61Cu]-N-(2-hydroxyacetophenone)glycinate ([61Cu]NHAG) was prepared using in house-made NHAG ligand and [61Cu]CuCl2 produced via the natZn(p,x)61Cu (180μA proton irradiation, 22MeV, 3.2h) and purified by a ion chromatography method. [61Cu]NHAG radiochemical purity was >98% and >99.9% by RTLC and HPLC methods respectively after purification by SPE. [61Cu]NHAG was administered into normal and tumor bearing mice followed by biodistribution studies up to 180 minutes. The best tumor accumulation was observed by animal sacrification after 120 min (tumor/muscle and tumor/blood ratios were 25.6 and 3.4 respectively). [61Cu]NHAG is a potential PET radiotracer for tumor imaging.
Keywords: Radiopharmaceuticals; Copper-61; NHAG; Biodistribution; Fibrosarcoma Radiopharmaceuticals; Copper-61; NHAG; Biodistribution; Fibrosarcoma

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MDPI and ACS Style

JALILIAN, A.R.; SADEGHI, H.; ZANDI, H.; ROWSHANFARZAD, P.; SHAFAII, K.; KAMALI-DEHGHAN, M.; GAROUSI, J.; MAJDABADI, A.; TAVAKOLI, M.B. Synthesis and Preclinical Studies of [61Cu]-N-(2-hydroxyacetophenone)glycinate as a Possible PET Radiopharmaceutical. Sci. Pharm. 2008, 76, 637-652. https://doi.org/10.3797/scipharm.0808-13

AMA Style

JALILIAN AR, SADEGHI H, ZANDI H, ROWSHANFARZAD P, SHAFAII K, KAMALI-DEHGHAN M, GAROUSI J, MAJDABADI A, TAVAKOLI MB. Synthesis and Preclinical Studies of [61Cu]-N-(2-hydroxyacetophenone)glycinate as a Possible PET Radiopharmaceutical. Scientia Pharmaceutica. 2008; 76(4):637-652. https://doi.org/10.3797/scipharm.0808-13

Chicago/Turabian Style

JALILIAN, Amir R., Hamid SADEGHI, Hassan ZANDI, Pejman ROWSHANFARZAD, Kamaledin SHAFAII, Mohsen KAMALI-DEHGHAN, Javad GAROUSI, Abbas MAJDABADI, and Mohammad B. TAVAKOLI. 2008. "Synthesis and Preclinical Studies of [61Cu]-N-(2-hydroxyacetophenone)glycinate as a Possible PET Radiopharmaceutical" Scientia Pharmaceutica 76, no. 4: 637-652. https://doi.org/10.3797/scipharm.0808-13

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