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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2008, 76(4), 637-652; (registering DOI)

Synthesis and Preclinical Studies of [61Cu]-N-(2-hydroxyacetophenone)glycinate as a Possible PET Radiopharmaceutical

Nuclear Medicine Research Group, Agricultural, Medical and Industrial Research School (AMIRS), Karaj, P.O.Box: 31485-498, Iran
Department of Biomedical Physics and Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Islamic Azad University, Science and Research Unit, P.O.Box: 14155-775, Tehran, Iran
Author to whom correspondence should be addressed.
Received: 19 August 2008 / Accepted: 14 September 2008 / Published: 17 September 2008
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[61Cu]-N-(2-hydroxyacetophenone)glycinate ([61Cu]NHAG) was prepared using in house-made NHAG ligand and [61Cu]CuCl2 produced via the natZn(p,x)61Cu (180μA proton irradiation, 22MeV, 3.2h) and purified by a ion chromatography method. [61Cu]NHAG radiochemical purity was >98% and >99.9% by RTLC and HPLC methods respectively after purification by SPE. [61Cu]NHAG was administered into normal and tumor bearing mice followed by biodistribution studies up to 180 minutes. The best tumor accumulation was observed by animal sacrification after 120 min (tumor/muscle and tumor/blood ratios were 25.6 and 3.4 respectively). [61Cu]NHAG is a potential PET radiotracer for tumor imaging.
Keywords: Radiopharmaceuticals; Copper-61; NHAG; Biodistribution; Fibrosarcoma Radiopharmaceuticals; Copper-61; NHAG; Biodistribution; Fibrosarcoma
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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JALILIAN, A.R.; SADEGHI, H.; ZANDI, H.; ROWSHANFARZAD, P.; SHAFAII, K.; KAMALI-DEHGHAN, M.; GAROUSI, J.; MAJDABADI, A.; TAVAKOLI, M.B. Synthesis and Preclinical Studies of [61Cu]-N-(2-hydroxyacetophenone)glycinate as a Possible PET Radiopharmaceutical. Sci. Pharm. 2008, 76, 637-652.

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