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Sci. Pharm.
Volume 72
Issue 3
10.3797/scipharm.aut-04-18
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Article

Study of local anesthetics. Part* 166:Conductometric determination of the critical micelle concentration of local anesthetic heptacainium chloride in aqueous electrolvte solution

by
F. Andriamainty
*,
J. Čižmárik
and
M. Holíková
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Odbojarov 10, 832 32 Bratislava, Slovakia
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2004, 72(3), 221-225; https://doi.org/10.3797/scipharm.aut-04-18
Submission received: 5 March 2004 / Revised: 11 August 2004 / Accepted: 11 August 2004 / Published: 11 August 2004
Versions Notes

Abstract

Specific conductivities of local anesthetic heptacainium chloride XlX (HCC XlX) (N-[2-(2-heptyloxyphenylcarbamoyloxy)-ethyl]-piperidinium chloride), in aqueous electrolyte solution (0.05 mol.1−1 NaCl) were measured as a function of the concentration and temperature. The critical micelle concentrations (c.m.c) and the counterion (β) binding of the micelles were estimated from the dependence of the specific conductivity of the substrate concentration. The temperature dependence of ln c.m.c was fitted to the function of the second degree polynomial. From the fitting parameters, Gibss free energies (ΔG0), enthalpies (ΔH0), and entropies (ΔS0) of micellization as a function of temperature were estimated. The "mass action model" was applied to micelle formation to calculate the micellization parameters.
Keywords: Heptacainium chloride; conductivity; micellization Heptacainium chloride; conductivity; micellization

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MDPI and ACS Style

Andriamainty, F.; Čižmárik, J.; Holíková, M. Study of local anesthetics. Part* 166:Conductometric determination of the critical micelle concentration of local anesthetic heptacainium chloride in aqueous electrolvte solution. Sci. Pharm. 2004, 72, 221-225. https://doi.org/10.3797/scipharm.aut-04-18

AMA Style

Andriamainty F, Čižmárik J, Holíková M. Study of local anesthetics. Part* 166:Conductometric determination of the critical micelle concentration of local anesthetic heptacainium chloride in aqueous electrolvte solution. Scientia Pharmaceutica. 2004; 72(3):221-225. https://doi.org/10.3797/scipharm.aut-04-18

Chicago/Turabian Style

Andriamainty, F., J. Čižmárik, and M. Holíková. 2004. "Study of local anesthetics. Part* 166:Conductometric determination of the critical micelle concentration of local anesthetic heptacainium chloride in aqueous electrolvte solution" Scientia Pharmaceutica 72, no. 3: 221-225. https://doi.org/10.3797/scipharm.aut-04-18

APA Style

Andriamainty, F., Čižmárik, J., & Holíková, M. (2004). Study of local anesthetics. Part* 166:Conductometric determination of the critical micelle concentration of local anesthetic heptacainium chloride in aqueous electrolvte solution. Scientia Pharmaceutica, 72(3), 221-225. https://doi.org/10.3797/scipharm.aut-04-18

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